Manufacturing method of mouse MCAO animal model

Abstract

The invention provides a manufacturing method of a mouse MCAO animal model. According to the method, a microsphere catheter suture device is adopted and comprises a catheter, a front-end microsphere and a tail-end microsphere, the front-end microsphere is arranged at the front end of the catheter, and the tail-end microsphere is arranged at the tail end of the catheter. The catheter is in the shape of a hollow tube, comprises a hollow channel and is made of a high polymer material. The front-end microsphere comprises a magnetic inner core and a sealing film, the sealing film wraps the magnetic inner core, the magnetic inner core is in a bullet shape, and the magnetic inner core is arranged to be capable of receiving microwaves so that the magnetic inner core can generate heat and rise the temperature. The sealing film is made of an elastic material, the inner space wrapped by the sealing film is communicated with the hollow channel of the catheter, and the sealing film is arranged to be melted when the temperature of the magnetic inner core is higher than 90 DEG C. According to the method provided by the invention, the suture device can be guided and positioned through the electromagnetic coil outside the blood vessel, and administration can be carried out through microwaves emitted from the outside of the blood vessel, so that the surgical operation difficulty is reduced, and the surgical success rate is increased.

Description

technical field [0001] The invention belongs to the field of medical research experimental devices. In particular, it relates to a method for making a mouse MCAO animal model. Background technique [0002] Stroke, also known as stroke and cerebrovascular accident, has the characteristics of high morbidity, high mortality and high disability rate, and its clinical manifestations are neurological dysfunction such as hemiplegia and aphasia. It is an acute cerebrovascular disease. Stroke is a group of diseases that cause damage to brain tissue due to sudden rupture of blood vessels in the brain or blockage of blood vessels that prevents blood from flowing into the brain, including ischemic and hemorrhagic strokes. The incidence of ischemic stroke is higher than that of hemorrhagic stroke, accounting for 60% to 70% of the total stroke. According to the survey, stroke in both urban and rural areas has become the number one cause of death in my country and the leading cause of di...

AI Technical Summary

Problems solved by technology

These operations are especially difficult to perform under a microscope, and require high personnel to operate, and careless operations can easily lead to surgical failure

[0006] In addition, although the method in the prior art uses a thread plug device with a drug delivery structure, the thread plug device needs to be energized to melt the sealing film, resulting in a complex structure, which is unacceptable in the MCAO animal model of mice of

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