Preparation method of temperature-sensitive magnetic molecularly imprinted polymer for selectively separating and enriching aristolochic acid I

A technology of magnetic molecular imprinting and aristolochic acid, which is applied in the fields of alkali metal compounds, chemical instruments and methods, alkali metal oxides/hydroxides, etc., to achieve good reusability, simple preparation methods, and great application prospects

Pending Publication Date: 2021-05-28
NANCHANG UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

In the existing published literature, there are few reports on the use of smart molecularly imprinted polymers for AAI, or only limited to magnetic molecularly imprinted polymers.

Method used

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  • Preparation method of temperature-sensitive magnetic molecularly imprinted polymer for selectively separating and enriching aristolochic acid I
  • Preparation method of temperature-sensitive magnetic molecularly imprinted polymer for selectively separating and enriching aristolochic acid I
  • Preparation method of temperature-sensitive magnetic molecularly imprinted polymer for selectively separating and enriching aristolochic acid I

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Embodiment 1

[0029]Preparation of temperature sensitive magnetic molecular blotting polymers for selective separation enriching aristolic acid I, including the following steps: (1) Preparation of oxide (GO); (2) Magnetic oxide (MAG @ Go); (3) Silica coated magnetic oxide elongated (MAG @ Go @ SiO2Preparation; (4) Preparation of Temperature Sensitive Magnetic Molecular Print Polymer (TMMIPS). Preparation processfigure 1 Indicated.

[0030](1) Preparation of oxide oxide (GO)

[0031]1.0 G graphite and 1.2 g of potassium nitrate were weed, mixed uniform, add 46 ml of ice-overdulfuric acid (98%), stirring under ice water bath for 30 min. 6.0 g of potassium permanganate was slowly added to the above mixed dispersion solution and continued to stir 15 min in an ice water bath. The ice water bath was removed, and the temperature of the reaction system was raised to 35 ° C, stirred for 1 h, then slowly added 90 mL of deionized water, raised the temperature of the reaction system to 98 ° C, continued to stir 30...

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Abstract

The invention discloses a preparation method of a temperature-sensitive magnetic molecularly imprinted polymer for selectively separating and enriching aristolochic acid I. The temperature-sensitive magnetic molecularly imprinted polymer is prepared by the following steps: (1) preparing graphene oxide; (2) preparing magnetic graphene oxide; (3) preparing silicon dioxide coated magnetic graphene oxide; (4) taking the silicon dioxide coated magnetic graphene oxide as a carrier, taking aristolochic acid I as a template molecule, taking N-isopropylacrylamide as a temperature-sensitive functional monomer, taking methacrylic acid as a functional monomer, taking divinyl benzene as a cross-linking agent and taking azodiisobutyronitrile as an initiator, and preparing the temperature-sensitive magnetic molecularly imprinted polymer with specific recognition capability on aristolochic acid I on the surface of the carrier. The temperature-sensitive magnetic molecularly imprinted polymer prepared by the method can be rapidly separated under an external magnetic field, has relatively high specific adsorption capacity and recognition rate on a target compound, can be repeatedly used, is reversible and controllable in adsorption/desorption process along with temperature change, and is environment-friendly.

Description

Technical field[0001]The present invention relates to a preparation method for selectively separating a temperature sensitive magnetic molecular blotting polymer, a functional material preparation and an endogenous contaminant analysis technique.Background technique[0002]Madotic acid I (AAI) is a nitrogenic compound, which is widely existing in the Maota Corpocolis and fine art. Plants containing AAI have been used for arthritis, rheumatism, diuretic, poisonous snake bite, cancer, and the like adjuvant treatment. In recent years, AAI's various poisonous side effects have been reported successively, and their nephrotoxicity is most eye-catching. Multi-group lavivia experiments have also confirmed that it has mutation and carcinogenic effects. Currently, in the preliminary list of carcinogenes published by the World Health Organization International Cancer Research Institute, the plants containing the Taro-containing acid were included in the 1 category cargo list. Although many count...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/36C08F220/06C08F220/54C08K9/10C08K3/04C08J9/26B01J20/26B01J20/28
CPCB01J20/268B01J20/28009C08F212/36C08J9/26C08J2325/02C08K9/10C08K2201/01C08K3/042C08F220/06C08F220/54
Inventor 万益群熊辉煌郭岚万昊范庸郭娴
Owner NANCHANG UNIV
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