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Preparation method of peppermint oil nano-emulsion

A nano-emulsion, peppermint oil technology, applied in the directions of emulsion delivery, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., can solve the problems of high volatility, limited antibacterial effect, poor water solubility of peppermint essential oil, etc. , to achieve the effects of improving the stability of the emulsion, increasing the solubility, and overcoming the volatile and poor water solubility.

Inactive Publication Date: 2021-06-01
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the shortcomings of peppermint essential oil such as poor water solubility and high volatility, its antibacterial effect is greatly limited.

Method used

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  • Preparation method of peppermint oil nano-emulsion
  • Preparation method of peppermint oil nano-emulsion
  • Preparation method of peppermint oil nano-emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation of emulsifier: 1.2 g of Tween-60 and 0.4 g of EL-20 were mixed to obtain 1.6 g of emulsifier.

[0021] Mix 2.0 g of peppermint oil and 1.6 g of emulsifier to prepare a mixture of emulsifier and oil, and stir for 12 hours; then add 16.4 g of deionized water to the above mixing system, and then shear 7 at a speed of 8000 r / min Min high-energy emulsification method, that is, O / W type peppermint oil nanoemulsion.

Embodiment 2

[0023] Preparation of emulsifier: 1.2 g of Tween-60 and 0.4 g of EL-20 were mixed to obtain 1.6 g of emulsifier.

[0024] Mix 2.0 g of peppermint oil and 1.6 g of emulsifier to prepare a mixture of emulsifier and oil, and stir for 12 hours; then add 16.4 g of deionized water into the above mixing system, and then shear 7 at a speed of 10000 r / min Min high-energy emulsification method, that is, O / W type peppermint oil nanoemulsion.

Embodiment 3

[0026] Preparation of emulsifier: 1.2 g of Tween-60 and 0.4 g of EL-20 were mixed to obtain 1.6 g of emulsifier.

[0027] Mix 2.0 g of peppermint oil and 1.6 g of emulsifier to prepare a mixture of emulsifier and oil, and stir for 12 hours; then add 16.4 g of deionized water to the above mixing system, and then shear 7 at a speed of 12000 r / min Min high-energy emulsification method, that is, O / W type peppermint oil nanoemulsion.

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Abstract

A preparation method of peppermint oil nano-emulsion relates to the technical field of preparation of bacteriostatic agent nano-emulsion, and comprises the following steps: mixing and stirring peppermint oil and an emulsifier, adding deionized water, and treating the mixed system by a high-energy emulsification method to obtain the peppermint oil nano-emulsion. The peppermint oil nano-emulsion prepared by the method disclosed by the invention is in a stable O / W type, and the sterilization rate of the nano-emulsion on gram-negative bacteria (escherichia coli) reaches 99%.

Description

technical field [0001] The invention relates to the technical field of preparation of antibacterial agent nanoemulsions, in particular to the production technology of peppermint oil nanoemulsions. Background technique [0002] With the ever-changing environment of human beings, especially the outbreak of COVID-19, people pay more attention to the prevention and treatment of microorganisms, especially bacteria and viruses. Staphylococcus aureus and Escherichia coli are important pathogenic bacteria in people's daily life. At present, for the prevention and treatment of such bacteria, people generally use β-lactam (such as penicillin), cephalosporins or carbapenems, aminoglycosides and sulfonamides and other antibiotics to inhibit bacteria; in addition, inorganic materials such as Micro or nano materials of Zinc (Zn), Silver (Ag), Copper (Cu) and Gold (Au) are used for antimicrobial use. With the widespread use of such products, in addition to common human side effects, ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K36/534A61K47/26A61K47/44A61P31/04
CPCA61K9/1075A61K36/534A61K47/26A61K47/44A61P31/04Y02A50/30
Inventor 刘岐高园王子旋颛孙相勋傅玄
Owner YANGZHOU UNIV