High-sensitivity weak fluorescence signal detection system and method, storage medium and application
A fluorescent signal, high-sensitivity technology, applied in the field of biomedical imaging, can solve the problems of technical cost, imaging quality and imaging speed imbalance, and achieve the effect of improving imaging sensitivity, reducing cost and improving sensitivity
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Embodiment 1
[0086] see figure 2 , figure 2 It is an overall schematic diagram of a high-sensitivity weak fluorescent signal detection system provided by an embodiment of the present invention. A high-sensitivity weak fluorescent signal detection system provided by an embodiment of the present invention includes:
[0087] The front fluorescent signal collection module 1 uses a specially customized optical signal collection lens to receive the fluorescent signal from the sample, and filters out stray light signals and collects the fluorescent signal;
[0088] A multi-channel spatial encoding module 2, configured to perform multi-channel spatial encoding on the fluorescent signals collected by the front fluorescent signal collection module 1 and compress them into a multi-channel one-dimensional fluorescent signal array;
[0089] The array weak signal detection module 3 is used to receive a multi-channel one-dimensional fluorescent signal array and convert the multi-channel one-dimension...
Embodiment 2
[0092] see image 3 , Figure 4 and Figure 5 , image 3 It is a schematic structural diagram of a high-sensitivity weak fluorescent signal detection system provided by an embodiment of the present invention, Figure 4 is a schematic diagram of a single-channel spatial encoding process provided by an embodiment of the present invention, Figure 5 A schematic diagram of a transformation mode of four-channel spatial coding provided by an embodiment of the present invention.
[0093] The pre-fluorescence signal collection module 1 includes an optical signal collection lens 11 , a focusing lens 12 and a filter 13 , and the optical signal collection lens 11 , the focusing lens 12 and the filter 13 are sequentially arranged along the optical path of the system.
[0094] An optical signal collecting lens 11, configured to collect the fluorescent signal generated by the fluorescent sample and transmit the fluorescent signal to the focusing lens 12;
[0095] The optical signal col...
Embodiment 3
[0131] An application scenario of the high-sensitivity weak fluorescence signal detection method provided by the embodiment of the present invention is the fluorescence imaging scenario of small animals. In the small animal fluorescence imaging scene, the present invention can replace the traditional area detector CCD camera, greatly improve the detection sensitivity of the small animal fluorescence imaging technology to the small animal fluorescence signal, and at the same time reduce the cost of the CCD camera in the small animal fluorescence imaging technology. resulting price costs. The present invention can also be applied to other weak light imaging scenes with large field of view that require high sensitivity to weak light detection, including but not limited to small animal fluorescence imaging scenes, bioluminescence imaging scenes, Cerenkov fluorescence imaging scenes and Raman imaging scenes. Scattering imaging scenes, etc.; the main feature of the single-point dete...
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