Injection needle coating material and application thereof in surface treatment of peripheral blood taking needle head

A coating material, injection needle technology, applied in coating, application, medical science and other directions, can solve problems such as unfavorable assays, and achieve the effects of alleviating pain, improving performance, and increasing lubricity

Pending Publication Date: 2021-06-15
PROMISEMED HANGZHOU MEDITECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a coating material for injection needles and its application in the surface treatment of peripheral blood collection needles. The coating material has good adhesion, is coated on the needle surface, is not easy to fall off, and can greatly reduce The pain of the patient's body during puncture; it has excellent anticoagulant effect, which can relieve the problem that the patient's blood coagulates quickly and is not conducive to subsequent laboratory tests

Method used

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  • Injection needle coating material and application thereof in surface treatment of peripheral blood taking needle head
  • Injection needle coating material and application thereof in surface treatment of peripheral blood taking needle head
  • Injection needle coating material and application thereof in surface treatment of peripheral blood taking needle head

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of modified silicone oil:

[0024] Dissolve caffeic acid lupeyl alcohol and polymethylhydrogensiloxane (the mass ratio of caffeic acid lupeyl alcohol and polymethylhydrogensiloxane is 4.2:1) in DMSO, and raise the temperature to 85°C under nitrogen protection. Add 5ppm of speier catalyst, react for 5h; filter while hot, cool to room temperature, spin evaporate, dry, and separate and purify by column chromatography to obtain modified silicone oil.

[0025] A raw material component of a coating solution for an injection needle coating material includes: in parts by weight, 3.5 parts of modified silicone oil, 28 parts of 4-chlorobenzotrifluoride, 25 parts of ethyl acetate, 3 parts of hydroxypropylmethyl Cellulose, 6 parts dimethylformamide.

[0026] An injection needle coating material forms a coating on the surface of the needle by impregnating the injection needle with a coating solution. The thickness of the formed coating is 15±0.7 μm.

Embodiment 2

[0028] The preparation of modified silicone oil is identical with embodiment 1;

[0029] A raw material component of a coating solution for an injection needle coating material includes: in parts by weight, 3.5 parts of modified silicone oil, 28 parts of 4-chlorobenzotrifluoride, 25 parts of ethyl acetate, 3 parts of hydroxypropylmethyl Cellulose, 6 parts dimethylformamide, 1.2 parts fucoidan sulfate.

[0030] The preparation of an injection needle coating material is the same as in Example 1, and the thickness of the formed coating is 24.5±0.3 μm.

Embodiment 3

[0032] The difference between the preparation of modified silicone oil and Example 2 is that the mass ratio of caffeic acid lupeyl alcohol and polymethylhydrogensiloxane is 3.8:1;

[0033] A raw material component of a coating solution for an injection needle coating material includes: by weight, 2 parts of modified silicone oil, 22 parts of 4-chlorotrifluorotoluene, 16 parts of ethyl acetate, 2 parts of hydroxypropylmethyl Cellulose, 5 parts of dimethylformamide, 0.9 parts of fucoidan sulfate.

[0034] The preparation of an injection needle coating material is the same as in Example 1, and the thickness of the formed coating is 14.3±0.5 μm.

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Abstract

The invention discloses an injection needle coating material and application thereof in surface treatment of a peripheral blood taking needle head, and relates to the technical field of biomedical materials. According to the injection needle coating material, an injection needle head is soaked in a coating solution to form a coating on the surface of the needle head, and the coating solution is prepared from the following raw materials in parts by weight: 1 to 4 parts of modified silicone oil, 20 to 30 parts of 4-chlorobenzotrifluoride, 15 to 30 parts of ethyl acetate, 2 to 4 parts of hydroxypropyl methyl cellulose, 3 to 8 parts of dimethylformamide, 0.5 to 2 parts of fucosan sulfate and 0.1 to 1 part of luteolin-5-O-glucoside. The coating material prepared by the invention has good cohesiveness, is not easy to fall off when being coated on the surface of the needle head, and can greatly reduce the pain of a sick body during puncture; and the coating material has an excellent anticoagulant effect, and can relieve the problem that the blood coagulation of a patient is fast and is not beneficial to follow-up test.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an injection needle coating material and its application in the surface treatment of peripheral blood collection needles. Background technique [0002] Peripheral blood collection needle is a kind of commonly used medical device, utilizes the needle point of blood collection needle to puncture patient's skin to collect blood sample. There are various structures of lancets currently on the market, most of which belong to the triggered ejection type. In the prior art, most injection needles are stainless steel disposable needles, and the friction between the surface of the needle and the flesh tissue is relatively large when the needle is pricked. Therefore, the pain is relatively strong, and it is necessary to study how to reduce the pain of injection or blood collection. And in the process of blood collection in the hospital, some patients release thromb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/14A61L31/16A61B5/151
CPCA61L31/10A61L31/08A61L31/14A61L31/16A61B5/150022A61B5/150381A61B5/151A61L2300/606A61L2300/216A61L2300/42A61L2300/45A61L2300/23A61L2300/232
Inventor 胡超宇鲁艳石家涵
Owner PROMISEMED HANGZHOU MEDITECH
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