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Agent for controlling sebaceous glands

A technology of sebaceous glands and external preparations, applied in the field of external preparations, which can solve the problems of not assuming the use of external preparations, and achieve the effects of promoting or inhibiting sebum secretion, preventing or improving dry skin, and preventing or improving oily skin

Pending Publication Date: 2021-06-15
THE RITSUMEIKAN TRUST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, Patent Documents 1 to 7 basically disclose oral administration of lactic acid bacteria, and do not assume their use as an external preparation

Method used

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  • Agent for controlling sebaceous glands
  • Agent for controlling sebaceous glands
  • Agent for controlling sebaceous glands

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0071] experimental method

[0072] 1. Cell sample preparation: FK-23

[0073] Enterococcus faecalis NF-1011 strain was cultured at 37°C for 18 hours in a liquid medium (glucose: 2%, yeast extract: 2%, peptone: 2%, dipotassium hydrogenphosphate: 4%). Using microfiltration membranes, harvest and wash to collect viable cells. Live cells were heat-treated at 110 °C for 10 min and then dried by spray drying. The resulting dried dead cells were used as cell samples (FK-23) in the following experiments.

[0074] 2. Cell Sample Preparation: LFK

[0075] Enterococcus faecalis NF-1011 strain was inoculated in 10 ml Rogosa liquid medium, and aerobic static culture (preliminary culture) at 37°C for 15 hours to obtain a cell concentration of about 10 9 cells / ml of cell solution (seed). Cells were inoculated in 10L of Rogosa liquid medium (cell concentration: 10 6 cells / ml), and aerobic static culture at 37°C for 16 hours to obtain a viable cell count of about 10 9 cells / ml of cell ...

experiment example 2

[0082] experimental method

[0083]In order to search for a component in FK-23 showing the effect confirmed in Experimental Example 1, by figure 2 The method shown performs the grading (sub-painting) of FK-23.

[0084] A filtrate obtained by suspending FK-23 prepared in Experimental Example 1 in saturated physiological saline, and subjecting the suspension to suction filtration was fractionated by solvent extraction using ethyl acetate. The resulting ethyl acetate layer was dried and solidified using a reduced-pressure evaporator, and then ethyl acetate was added to separate a soluble part and an insoluble part. Ethyl acetate-soluble components were fractionated by solvent extraction (vehicle partition) using 90% MeOH and hexane. As a result, the 90% MeOH fraction showed strong activity, so a medium-pressure column was used for purification. As a medium-pressure column, ODS (SHOKO Purif-Pack (trademark)-EX ODS-50 μm, size: 20, 60×20 mm I.D., manufactured by SHOKO TECHNOLOG...

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Abstract

Disclosed is an external agent for normalizing sebaceous glands, said external agent comprising a component which is at least one member selected from cells of a lactic acid bacterium belonging to the genus Enterococcus or a cell component thereof or a component extracted from cells of a lactic acid bacterium belonging to the genus Enterococcus and soluble in ethyl acetate.

Description

technical field [0001] The present invention relates to an external preparation for normalizing sebaceous glands. Background technique [0002] Acne (acne vulgaris) is a chronic inflammatory disease of the pilosebaceous unit whose prominent pathophysiology is thought to include increased sebum secretion due to the sebaceous gland-stimulating action of androgens, pore blockage due to abnormal keratinization of the funnel-shaped hair follicles and the presence of organisms in funnel-shaped hair follicles. Other internal and external factors are also considered, including genetic factors, age, dietary factors, environmental factors (such as temperature and humidity), mechanical stimuli, stress, cosmetics, and drugs. [0003] Lactic acid bacteria belonging to the genus Enterococcus are known to have various effects on living organisms. [0004] For example, Enterococcus faecalis NF-1011 strain has been reported to have the following effects: suppression of blood pressure incre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/744A61P43/00A61P17/00A61P17/08A61P17/10A61P17/16A61K8/99A61Q15/00A61Q19/00C12N1/20
CPCA61K8/99A61K35/744A61P17/16A61P17/00A61P17/08A61P17/10A61P43/00C12N1/20A61Q19/008A61K2035/115A61Q15/00A61Q19/00
Inventor 藤田隆司嶋田贵志
Owner THE RITSUMEIKAN TRUST
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