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Application of mdl-800 in the preparation of drugs for inhibiting susceptibility to sars-cov-2 virus

A technology of MDL-800, 1. MDL-800 is applied in the application field of preparing medicines for inhibiting SARS-CoV-2 virus susceptibility, and can solve the problems such as no reports on MDL-800 anti-coronavirus medicines.

Active Publication Date: 2022-04-15
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report of MDL-800 as a drug for preparing anti-coronavirus

Method used

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  • Application of mdl-800 in the preparation of drugs for inhibiting susceptibility to sars-cov-2 virus
  • Application of mdl-800 in the preparation of drugs for inhibiting susceptibility to sars-cov-2 virus
  • Application of mdl-800 in the preparation of drugs for inhibiting susceptibility to sars-cov-2 virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1, MDL-800 inhibits the susceptibility of SARS-CoV-2 to cells

[0046] (1) Construction of Caco-2 and Calu-3 cell lines stably expressing luciferase Rluc

[0047] In order to construct Caco-2 and Calu-3 cell lines stably expressing Renilla-luciferase (RLuc), we first packaged Rluc lentiviral particles (RLuc lentiviral expression vector pHHLVX-EF1α-Rluc-puro was purchased from HedgehogBio Science and Technology Ltd ).

[0048] First, HEK293T cells were cultured in T-75 cell culture flasks with 15ml DMEM medium containing 10% fetal bovine serum until the density reached 70%; 2.8μg), VSV-G (3.92μg) and pHHLVX-EF1α-Rluc-puro (7μg), and 58.8μl PEI (1mg / ml) were mixed in 1.5ml serum-free DMEM, reacted at room temperature for 15 minutes and added to HEK293T cells . Change the medium 6 hours after transfection; 48 hours after transfection, centrifuge at 1000g for 10 minutes to remove cell debris, collect the supernatant, then filter with a 0.45μm filter, place the fi...

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PUM

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Abstract

The invention discloses the medical application of MDL-800. The use is the following (a) and / or (b) and / or (c) and / or (d) and / or (e): (a) MDL-800 is used to prepare and treat diseases caused by coronavirus or coronavirus (b) the use of MDL-800 in the manufacture of products for the prevention of coronavirus-caused disease or coronavirus infection; (c) the use of MDL-800 in the manufacture of products for the inhibition of coronavirus susceptibility; (d) application of MDL-800 in the preparation of products for reducing the risk of coronavirus infection; (e) application of MDL-800 in the preparation of coronavirus inhibitors. The present invention finds through research that MDL-800 can reduce the infection risk of SARS-CoV-2 virus.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of MDL-800 in the preparation of drugs for inhibiting SARS-CoV-2 virus susceptibility. Background technique [0002] Coronavirus (Coronavirus, CoV) exists widely in nature. It is a kind of RNA virus with envelope and genome of linear single-stranded positive strand. CoV only infects vertebrates and is related to various diseases of humans and animals. It can cause human And animal respiratory tract, digestive tract and nervous system diseases. Viral pneumonia (COVID-19) caused by a novel coronavirus (SARS-CoV-2) has become a public health emergency of international concern. [0003] Epigenetic regulation is an important mechanism for the maintenance of life homeostasis, among which histone acetylation has been found to be one of the modifications most closely related to the physiological functions and pathological manifestations of the body. SIRT...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/245A61P31/14A61P11/00A61P1/12A61P11/04A61P11/02
CPCA61K31/245A61P31/14A61P11/00A61P1/12A61P11/04A61P11/02
Inventor 程龙叶棋浓金蕊张晓娜徐山茸王瑞官
Owner ACADEMY OF MILITARY MEDICAL SCI