Concentration method and device for low-specific-activity <99m>Tc solution

A technology of 99mtc and specific activity, which is applied in the field of medical radioisotope application, can solve the problems of limited application and achieve the effects of increasing specific activity, promoting promotion and application, and reducing concentration costs

Active Publication Date: 2021-06-22
西安迈斯拓扑科技有限公司
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Problems solved by technology

[0005] In order to solve the low specific activity 99m The problem of the limited clinical application of Tc solution in nuclear medicine, the invention discloses a low specific activity 99m Concentration method and device for Tc solution

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  • Concentration method and device for low-specific-activity &lt;99m&gt;Tc solution
  • Concentration method and device for low-specific-activity &lt;99m&gt;Tc solution
  • Concentration method and device for low-specific-activity &lt;99m&gt;Tc solution

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Embodiment Construction

[0054] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0055] The invention discloses a low specific activity 99m The concentration method of Tc solution needs to establish a set of low specific activity during concrete implementation 99m The Tc concentrator is a collection of the used separation column, vessel and solution and placed in a hot room or a suitable lead tank for use. The concentration device mainly includes acidic alumina column 1 and anion resin column 2 (in this embodiment, the anion resin column is Dowex-1 anion resin column, and in other embodiments, the anion resin column can be AG-1 type, TEVA, etc., especially related to Dowex-1×8 and AG-1×8 resin), AgCl column 3, radioactive waste liquid bottle 4 and sterile vial 5, which are connected by three-way valve and hose. low specific activity 99m Tc concentration device such as figure 2 As can be seen from the figure, the device...

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Abstract

The invention discloses a concentration method and device for a low-specific-activity <99m>Tc solution. The method comprises the following steps: adsorbing low-specific-activity < 99 > Mo (containing a large amount of < 98 > Mo and < 100 > Mo) feed liquid by using an acidic alumina column, generating enough < 99m > Tc after < 99 > Mo is decayed for a certain time, leaching < 99m > Tc by using normal saline, and concentrating the low-specific-activity < 99m >Tc normal saline solution by using an anion resin column and an AgCl column to obtain a high-specific-activity < 99m >Tc solution. According to the method, the popularization and application of the non-fission < 99 > Mo production method can be promoted, the problem of application of the low-specific-activity < 99m >Tc solution in nuclear medicine clinic is solved, and the service life of a fission < 99 > Mo-< 99m >Tc generator can also be prolonged.

Description

technical field [0001] The invention relates to the application field of medical radioactive isotopes, in particular to a low specific activity 99m Concentration method and device for Tc solution. Background technique [0002] 99m Tc has a half-life of 6.02h and emits 140KeV γ-rays. Because of its short half-life and the energy of γ-rays is suitable for detection, it is the most widely used isotope in nuclear medicine clinically. Currently, 99m Tc drugs account for about 80% of clinical radiopharmaceuticals, and are commonly used in SPECT imaging diagnosis of heart, liver, lung, spleen, kidney, bone, brain, blood cells, lymph and other diseases and tumors. [0003] 99m Tc generally consists of 99 Mo- 99m Adsorbed on the acidic alumina column in the Tc generator 99 Mo is produced by β decay, washed with saline and then Na 99m TCO 4 form obtained. [0004] 99 Mo can be produced by fission and non-fission methods. The fission method uses reactor neutron irradiation ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D59/50
CPCB01D59/50Y02W10/37
Inventor 王思弘张宇皓王柏松李韶亮
Owner 西安迈斯拓扑科技有限公司
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