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Heterogeneous bone tissue engineering scaffold, extrusion assembly and preparation method of heterogeneous bone tissue engineering scaffold

A bone tissue engineering, heterogeneous technology, applied in tissue regeneration, bone implants, pharmaceutical formulations, etc., can solve problems such as rejection, limited sources of prosthesis or implant materials, and inability to effectively control the scope of action of chemotherapy drugs. Achieving the effect of avoiding harm and preventing the recurrence of osteosarcoma

Active Publication Date: 2021-06-25
承德石油高等专科学校
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of this, one of the objectives of the present invention is to provide a heterogeneous bone tissue engineering scaffold to solve the problem that the surgical treatment of osteosarcoma in the prior art cannot effectively control the range of action of chemotherapy drugs, and the prosthesis or graft materials used at the same time exist. Technical issues of source limitation and risk of rejection

Method used

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  • Heterogeneous bone tissue engineering scaffold, extrusion assembly and preparation method of heterogeneous bone tissue engineering scaffold
  • Heterogeneous bone tissue engineering scaffold, extrusion assembly and preparation method of heterogeneous bone tissue engineering scaffold
  • Heterogeneous bone tissue engineering scaffold, extrusion assembly and preparation method of heterogeneous bone tissue engineering scaffold

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Embodiment 1

[0046] The additive manufacturing device includes a moving assembly 1 and an extrusion assembly 2, and this embodiment provides an extrusion assembly 2, such as figure 2 As shown, this extrusion component 2 can be used to prepare a heterogeneous bone tissue engineering scaffold, that is, to prepare a heterogeneous bone tissue engineering scaffold by extrusion, the extrusion component 2 moves to the bone defect site by moving the component 1, and the extrusion component 2. Extrude the heterogeneous bone tissue engineering scaffold fit to the bone defect site.

[0047] Specifically, such as Figure 4 and Figure 5 As shown, it is a structural schematic diagram of the mobile assembly 1 constituting the additive manufacturing device. The mobile assembly 1 includes a base 12, a worktable 11, an X-axis guide rail 14, an X-axis driver 141, a Y-axis guide rail 16, a Y-axis driver 161, and a Z-axis driver 161. Axis guide rail 15, Z-axis driver 151 and controller 13, the workbench 11...

Embodiment 2

[0057] The preparation method of the heterogeneous bone tissue engineering scaffold provided in this example is realized by using the extrusion assembly 2 described in the above-mentioned Example 1. During the formation of the body, it is fused with the heterogeneous melt. The heterogeneous melt is constructed by additive manufacturing technology, and its shape is the same as that of the bone defect, thereby forming a heterogeneous bone tissue engineering scaffold.

[0058] Such as figure 1 As shown, the heterogeneous bone tissue engineering scaffold specifically includes a scaffold body 3 constructed using additive manufacturing technology at the same position as the bone defect. The scaffold body 3 is made of degradable biocompatible materials. The surface or interior of the scaffold body 3 is embedded with Porous inorganic sustained-release microspheres containing chemotherapeutic drugs for osteosarcoma for the treatment of osteosarcoma31.

[0059] The stent body 3 is made...

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Abstract

The invention provides a heterogeneous bone tissue engineering scaffold, an extrusion assembly and a preparation method of the heterogeneous bone tissue engineering scaffold, and relates to the technical field of composite material preparation, the heterogeneous bone tissue engineering scaffold comprises a scaffold body which is constructed by utilizing an additive manufacturing technology and is the same as a bone defect position, and the scaffold body is made of a degradable biocompatible material; and chemical drug microspheres for treating osteosarcoma are embedded on the surface or in the stent body. The extrusion assembly is used for preparing the heterogeneous bone tissue engineering scaffold. The invention further discloses a preparation method of the heterogeneous bone tissue engineering scaffold. The scaffold can be used for repairing bone defects, meanwhile, the porous inorganic sustained-release microspheres in the scaffold can gradually release osteosarcoma chemotherapeutic drugs, accurate sustained release of the chemotherapeutic drugs at affected parts is achieved, osteosarcoma recurrence is prevented, and meanwhile damage of large-dose chemotherapeutic drugs to human healthy cells is avoided.

Description

technical field [0001] The invention relates to the technical field of composite material preparation, in particular to a heterogeneous bone tissue engineering scaffold, an extruded component and a preparation method thereof. Background technique [0002] With the gradual control of infectious diseases, malignant tumors have become a common disease that seriously endangers human health, and its incidence is still rising. According to the data released by the Ministry of Health of my country, whether in urban or rural areas, malignant tumors have become the number one cause of death surpassing cardiovascular diseases. Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, and its long-term survival rate is extremely poor. Osteosarcoma is a primary malignant solid tumor derived from bone-forming stem cells. It often occurs in the distal femur and proximal tibia and easily metastasizes to the lungs. Data show that adolescents and older adul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/44A61L27/46A61L27/54A61L27/56A61F2/28B33Y30/00B33Y70/10B33Y80/00
CPCA61L27/58A61L27/54A61L27/56B33Y70/10B33Y80/00B33Y30/00A61F2/28A61L27/46A61L27/446A61L2300/624A61L2300/416A61L2430/02A61L2300/602A61F2002/2835Y02P10/25
Inventor 强琳辉潘滋涵刘春艳苏倩
Owner 承德石油高等专科学校
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