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Calcium-phosphorus colloid complexing agent as well as preparation method and application thereof

A compound and colloid technology, applied in the direction of phosphorus compound active ingredients, drug combinations, pharmaceutical formulas, etc., can solve the problems of dairy economic losses, metabolic disorders, and heterophilia of dairy cows, and can prevent dairy cows from producing paralysis and promote calcium and phosphorus absorption. , good stability

Inactive Publication Date: 2021-07-09
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When dairy cows are deficient in calcium or phosphorus, it will cause a series of metabolic disorders in the body, which in turn will lead to diseases such as pica, rickets, decreased milk quality, reduced feed utilization, and paralysis of production in dairy cows, which will cause huge economic losses to the dairy industry.

Method used

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  • Calcium-phosphorus colloid complexing agent as well as preparation method and application thereof
  • Calcium-phosphorus colloid complexing agent as well as preparation method and application thereof
  • Calcium-phosphorus colloid complexing agent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A calcium-phosphorus colloid compound, each 500mL calcium-phosphorus colloid compound includes the following raw materials: 150g of calcium chloride dihydrate, 140mL of ultrapure water, 40g of calcium phosphate, 90mL of hydrochloric acid solution, and 9g of sodium hydroxyethyl cellulose;

[0025] Wherein, the hydrochloric acid solution is obtained by mixing concentrated hydrochloric acid and water according to equal volumes;

[0026] The sodium hydroxyethyl cellulose is medical sodium hydroxyethyl cellulose.

[0027] The preparation method of described calcium phosphorus colloid compound, comprises the following steps:

[0028] (1) Divide sodium hydroxyethyl cellulose into two equal parts;

[0029] (2) Take calcium chloride dihydrate, add ultrapure water, add a portion of hydroxyethyl cellulose sodium after dissolving, and obtain calcium chloride gel;

[0030] (3) Take calcium phosphate, add it to hydrochloric acid solution, after dissolving, add another part of hydro...

Embodiment 2

[0033] A calcium-phosphorus colloid compound, each 500mL calcium-phosphorus colloid compound includes the following raw materials: 155g of calcium chloride dihydrate, 160mL of ultrapure water, 43g of calcium phosphate, 110mL of hydrochloric acid solution, and 12g of sodium hydroxyethyl cellulose;

[0034] Wherein, the hydrochloric acid solution is obtained by mixing concentrated hydrochloric acid and water according to equal volumes;

[0035] The sodium hydroxyethyl cellulose is medical sodium hydroxyethyl cellulose.

[0036] The preparation method of described calcium phosphorus colloid compound, comprises the following steps:

[0037] (1) Divide sodium hydroxyethyl cellulose into two equal parts;

[0038] (2) Take calcium chloride dihydrate, add ultrapure water, add a portion of hydroxyethyl cellulose sodium after dissolving, and obtain calcium chloride gel;

[0039] (3) Take calcium phosphate, add it to hydrochloric acid solution, after dissolving, add another part of hyd...

Embodiment 3

[0042] A calcium-phosphorus colloid compound, each 500mL calcium-phosphorus colloid compound includes the following raw materials: 153 g of calcium chloride dihydrate, 155 mL of ultrapure water, 42.0 g of calcium phosphate, 105 mL of hydrochloric acid, and 11 g of sodium hydroxyethyl cellulose;

[0043] Wherein, the hydrochloric acid solution is obtained by mixing concentrated hydrochloric acid and water according to equal volumes;

[0044] The sodium hydroxyethyl cellulose is medical sodium hydroxyethyl cellulose.

[0045] The preparation method of the calcium-phosphorus colloid compound is the same as in Example 1.

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Abstract

The invention discloses a calcium-phosphorus colloid complexing agent, which is prepared from the following raw materials: 150 to 155g of calcium chloride dihydrate, 140 to 160mL of ultrapure water, 40 to 43g of calcium phosphate, 90 to 110mL of hydrochloric acid solution and 9 to 12g of sodium hydroxyethyl cellulose. The invention further discloses a preparation method of the calcium-phosphorus colloid complexing agent and application of same in veterinary drugs for adjusting calcium-phosphorus imbalance of dairy cows. The calcium-phosphorus colloid complexing agent prepared by the invention is uniform milk white liquid, the pH value is about 7.2, the stability is good; the content of calcium and the content of phosphorus are about 115 + / - 5 mg / mL and 16.4 + / - 2 mg / mL respectively, wherein the calcium content is high, the calcium-phosphorus balance of a dairy cow body can be adjusted, calcium-phosphorus absorption is promoted, and the agent has a good effect on calcium and phosphorus supplementation. The preparation is applied to veterinary drugs, can be used for preventing and treating diseases caused by calcium deficiency or calcium-phosphorus imbalance of clinical animals, and can prevent paralysis of dairy cows.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a calcium-phosphorus colloid compound and its preparation method and application. Background technique [0002] The dairy industry is an efficient animal husbandry industry, but behind the rapid development of the dairy industry, there are still many hidden problems, such as: many scattered farmers, small scale, low degree of intensification; low cultural quality of employees, backward feeding management methods, high incidence of disease ; Poor quality of dairy cow breeds, etc. Calcium and phosphorus are important constant elements in dairy cows. They play an important role in the metabolism and bone development of dairy cows. The two complement each other. If they are deficient or unbalanced, they will have adverse effects on the health of dairy cows. When dairy cows are deficient in calcium or phosphorus, it will cause a series of metabolic disorders i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/42A61K33/14A61K9/107A61K47/38A61P3/12A61P3/14A61P15/00A61P25/00
CPCA61K33/42A61K33/14A61K9/107A61K47/38A61P3/12A61P3/14A61P15/00A61P25/00
Inventor 王建国赵宝玉谭攀攀赵晨旭郭玺
Owner NORTHWEST A & F UNIV