Method for preparing benzo-6, 8-dihydroisoquinoline-1-selenious sulfuryl benzamide compound through bimetallic catalysis

A technology of sulfone benzamide and dihydroisoquinoline, which is applied in the field of chemical intermediate preparation and can solve problems such as non-conformity, destruction, and low reaction efficiency
CN113105481AInactive Publication Date: 2021-07-13JIYANG COLLEGE OF ZHEJIANG A & F UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIYANG COLLEGE OF ZHEJIANG A & F UNIV
Publication Date
2021-07-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for preparing a benzo-6, 8-dihydroisoquinoline-1-selenious sulfuryl benzamide compound as shown in a formula (IV) through bimetallic catalysis. The preparation method comprises the following steps: fully reacting 1,2,3,4 tetrahydroisoquinoline compound shown in a formula (I), sodium selenide compound shown in a formula (II) and 2 -bromobenzaldehyde compound shown in a formula (III) in DMSO solvent with magnesium acetate and copper acetate as catalysts and cesium carbonate as alkali, and treating the product to obtain benzo -6,8- dihydroisoquinoline- 1- selenious sulfonylbenzamide compound. The method has the advantages of low cost, simplicity in operation, excellent yield, meeting of green synthesis requirements and the like, and is suitable for industrial synthesis of drug intermediates related to dihydroisoquinoline compounds.
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Description

technical field

[0001] The invention belongs to the technical field of preparation of chemical intermediates, and in particular relates to a method for preparing benzo-6,8-dihydroisoquinoline-1-selenosulfonyl benzamides by bimetallic catalysis. Background technique

[0002] Dihydroisoquinoline derivatives are an important class of pharmaceutical and chemical intermediates. For example, they have various biological activities, including anti-tumor, antibacterial, analgesic, immune function regulation, anti-platelet aggregation, anti-arrhythmia, antihypertensive, etc. , have been used to synthesize a series of important drugs. Most of the isoquinoline alkaloid drugs have basic structures such as dihydroisoquinoline or isoquinoline derivatives. Therefore, such drugs can basically be further synthesized from simple dihydroisoquinoline derivatives come out. Benzo-6,8-dihydroisoquinoline-1-selensulfonyl benzamide compounds have good storage stability, and are suitable for the pr...

Claims

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