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Biodegradable intravascular stent and 3D printing preparation method thereof

A vascular stent and 3D printing technology, applied in medical science, surgery, additive processing, etc., can solve problems such as hindering blood vessel reconstruction, unfavorable multi-layer CT angiography, and thrombus formation, so as to improve degradation speed and good biocompatibility sex, enhance the effect of hardness

Inactive Publication Date: 2021-07-16
黄凯悦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional stents are made of metal, but metal stents are prone to some disadvantages; such as the possibility of thrombus formation, hindering blood vessel reconstruction, and unfavorable multi-slice CT angiography, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A biodegradable vascular stent is composed of the following ingredients in proportion by mass:

[0025] 35 parts of polylactic acid, 50 parts of sodium alginate, 10 parts of acellular dermal matrix;

[0026] Wherein, the acellular dermal matrix is ​​pigskin acellular dermal matrix;

[0027] The 3D printing preparation method of the biodegradable vascular stent comprises the following steps:

[0028] (1) Obtain the biomorphic data of the blood vessel to be repaired, and determine the structure of the mold core and vascular stent through the computer three-dimensional reconstruction model;

[0029] (2) According to the structure of the mold core and the vascular stent determined in step (1), use a computer to establish the model of the mold core and the vascular stent, and decompose the obtained model into a 15um two-dimensional sheet model;

[0030] (3) Import the model data obtained in step (2) into the 3D printing equipment, add the mixture of gelatin and polycaprola...

Embodiment 2

[0035] A biodegradable vascular stent is formed by mixing the following ingredients in parts by mass:

[0036] 80 parts of polylactic acid, 25 parts of sodium alginate, 25 parts of acellular dermal matrix;

[0037] Wherein, the acellular dermal matrix is ​​fetal calf skin acellular dermal matrix;

[0038] The 3D printing preparation method of the biodegradable vascular stent comprises the following steps:

[0039] (1) Obtain the biomorphic data of the blood vessel to be repaired, and determine the structure of the mold core and vascular stent through the computer three-dimensional reconstruction model;

[0040] (2) According to the structure of the mold core and the vascular stent determined in step (1), use a computer to establish the model of the mold core and the vascular stent, and decompose the obtained model into a 25um two-dimensional sheet model;

[0041] (3) Import the model data obtained in step (2) into the 3D printing equipment, and add the mixture made of gelati...

Embodiment 3

[0046] A biodegradable vascular stent is compounded by the following ingredients according to the mass ratio:

[0047] 65 parts of polylactic acid, 35 parts of sodium alginate, 20 parts of acellular dermal matrix;

[0048] Wherein, the acellular dermal matrix is ​​fetal calf skin acellular dermal matrix;

[0049] The 3D printing preparation method of the biodegradable vascular stent comprises the following steps:

[0050] (1) Obtain the biomorphic data of the blood vessel to be repaired, and determine the structure of the mold core and vascular stent through the computer three-dimensional reconstruction model;

[0051] (2) According to the structure of the mold core and the vascular stent determined in step (1), use the computer to establish the model of the mold core and the vascular stent, and decompose the obtained model into a 20um two-dimensional sheet model;

[0052] (3) Import the model data obtained in step (2) into the 3D printing equipment, and add the mixture of g...

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PUM

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Abstract

The invention belongs to the technical field of bioabsorbable stents, and particularly relates to a biodegradable intravascular stent and a 3D printing preparation method thereof. The biodegradable intravascular stent is composed of polylactic acid, sodium alginate and an acellular dermal matrix, and the intravascular stent prepared through the 3D printing technology is biodegradable and has high safety, wherein the acellular dermal matrix has good biocompatibility, has the biological performance of promoting cells to differentiate into blood vessels and nerves, and can accelerate the repair process of lesion blood vessels and improve the degradation speed of the intravascular stent.

Description

technical field [0001] The invention belongs to the technical field of bioabsorbable stents, in particular to a biodegradable vascular stent, in particular to a biodegradable vascular stent and a 3D printing preparation method thereof. Background technique [0002] Scaffold materials are often used in surgical operations, such as vascular stents and intestinal stents that provide support, as well as artificial bone stents and artificial organ stents that serve as nutrient carriers and provide a certain size structure. Early stent materials usually use metal or some other non-degradable materials, which usually require secondary surgery to remove, and are accompanied by some negative effects; while bioabsorbable stents are made of materials that can dissolve in the human body, after being placed in the body , can be absorbed by the body. [0003] Vascular stents are surgically placed into human blood vessels or other tubes to expand blood vessels and prevent or reduce blocka...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/06A61L31/04A61L31/00B33Y80/00B33Y10/00B33Y70/10
CPCA61L31/005A61L31/042A61L31/06A61L31/14A61L31/148B33Y10/00B33Y70/00B33Y80/00C08L67/04C08L5/04
Inventor 黄凯悦
Owner 黄凯悦
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