Magnetic particle imaging system matrix image reconstruction method and system based on forward model

Abstract

The invention belongs to the field of magnetic nanoparticle imaging, particularly relates to a magnetic particle imaging system matrix image reconstruction method and system based on a forward model, and aims to solve the problem that efficiency and precision cannot be considered in magnetic nanoparticle image reconstruction due to the fact that a system matrix is difficult to obtain in the prior art. The method comprises the following steps: constructing response of a single magnetic particle under an external excitation magnetic field, and obtaining a magnetic moment vector of the single magnetic particle; constructing the response of the plurality of magnetic particles under the external excitation magnetic field by adopting a Langevin function, and obtaining the magnetic moment vectors of the plurality of magnetic particles; the induction voltage of the detection coil is obtained, and a system matrix is obtained through filtering and amplification of the data acquisition circuit; and reconstructing magnetic particle concentration distribution by using the system matrix and the acquired voltage signal, thereby realizing magnetic particle image reconstruction of the target detection object. According to the method, the speed of obtaining the MPI system matrix is high, universality is achieved for multiple MPI system structures and different magnetic nanoparticles, and the reconstruction time is saved on the premise that the reconstruction precision and accuracy are kept.

Description

technical field [0001] The invention belongs to the field of magnetic nanoparticle imaging, and in particular relates to a matrix image reconstruction method and system for a magnetic particle imaging system based on a forward model. Background technique [0002] Magnetic Particle Imaging (MPI, Magnetic Particle Imaging) is a relatively new imaging method, which reconstructs the spatial concentration distribution of particles according to the response of superparamagnetic iron oxide nanoparticles (SPIO, Superparamagnetic Iron Oxide Nanoparticles) to electromagnetic fields. Precise positioning of detection objects such as tumors. The voltage signal output by the MPI receiver coil contains the voltage caused by the nonlinear response of the SPIOs to the applied dynamic magnetic field. This part of the voltage signal is used for image reconstruction of the concentration distribution. The high temporal resolution, high spatial resolution, and absence of any harmful radiation o...

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Problems solved by technology

[0005] In order to solve the above-mentioned problems in the prior art, that is, the difficulty in obtaining the system matrix in the prior art leads to the problem that the reconstruction of the magnetic nanoparticle image cannot take into account both efficiency and accuracy, the present invention provides a matrix image of the magnetic particle imaging system based on the forward model A rebuild method that includes:

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