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Application of Xianglian product or combination of Xianglian product and antibiotics in anti-helicobacter pylori drugs

A technology of Helicobacter pylori and its products, which is applied in antibacterial drugs, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., which can solve the problems of poor safety and achieve high safety and simple preparation process , Improve the effect of antibacterial activity

Inactive Publication Date: 2021-07-23
重庆伊士腾生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, there is no precedent for the treatment or prevention of fatty liver, liver fibrosis, liver cirrhosis and liver cancer, and the safety of many products is relatively poor.

Method used

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  • Application of Xianglian product or combination of Xianglian product and antibiotics in anti-helicobacter pylori drugs
  • Application of Xianglian product or combination of Xianglian product and antibiotics in anti-helicobacter pylori drugs
  • Application of Xianglian product or combination of Xianglian product and antibiotics in anti-helicobacter pylori drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Weigh 80 g of Yuhuanglian, extract by percolation with 0.5% sulfuric acid solution, until the color of the percolation liquid is very light (the total alkaloids in the extracted raw materials are more than 95% according to HPLC analysis); the percolation liquid is neutralized to pH=3.0 with calcium hydroxide , filtered; the filtrate was concentrated under reduced pressure to 1g Yuhuanglian / mL, cooled, and filtered; 10% sodium chloride was added to the filtrate, and stood at 5°C for 24 hours, precipitated and filtered to obtain extract Ⅰ; the filtered mother liquor was added 10% sodium chloride, and 0.5% zinc chloride, stand still at 5°C for 5 hours, precipitate and filter to obtain extract II; combine extract I and extract II precipitate to obtain Yuhuanglian extract.

[0045] Weigh 20g of Muxiang, extract with 5 times of water reflux for 1 hour, and collect volatile oil; filter the extracted aqueous solution, and then reflux the filtered residue with an appropriate amou...

Embodiment 2

[0048] Weigh 80 g of Yuhuanglian, extract by percolation with 2% sulfuric acid solution, until the color of the percolate is very light (the total alkaloids in the extracted raw materials are more than 95% according to HPLC analysis); the percolate is neutralized to pH=7.0 with calcium hydroxide , filtered; the filtrate was concentrated under reduced pressure to 2g Yuhuanglian / mL, cooled, and filtered; 1% potassium bromide was added to the filtrate, and stood still for 96 hours at 25°C, precipitated and filtered to obtain extract Ⅰ; the filtered mother liquor was added 20% potassium bromide, and 0.1% ferric bromide, stand at 25°C for 1 hour, precipitate and filter to obtain extract II; combine extract I and extract II precipitate to obtain Yuhuanglian extract.

[0049] Weigh 20g of Muxiang, extract with 5 times of water reflux for 1 hour, and collect volatile oil; filter the extracted aqueous solution, and then reflux the filtered residue with an appropriate amount of water to ...

Embodiment 3

[0052] Weigh 80 g of Yuhuanglian, extract by percolation with 1% sulfuric acid solution, until the color of the percolate is very light (the total alkaloids in the extracted raw materials are more than 95% according to HPLC analysis); the percolate is neutralized to pH=5.0 with calcium hydroxide , filtered; the filtrate was concentrated under reduced pressure to 1g Yuhuanglian / mL, cooled, and filtered; 10% sodium iodide was added to the filtrate, and stood at 10°C for 48 hours, precipitated and filtered to obtain extract Ⅰ; the filtered mother liquor was added 10% sodium iodide, and 0.5% magnesium iodide, stand still at 10°C for 10 hours, precipitate and filter to obtain extract II; combine extract I and extract II precipitate to obtain Yuhuanglian extract.

[0053] Weigh 20g of Muxiang, extract with 5 times of water reflux for 1 hour, and collect volatile oil; filter the extracted aqueous solution, and then reflux the filtered residue with an appropriate amount of water to ext...

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Abstract

The invention provides an application of an Xianglian product or a combination of the Xianglian product and antibiotics in anti-helicobacter pylori drugs aiming at the characteristics of poor safety, poor clinical compliance and the like of the existing Xianglian product in resisting Hp or treating or preventing fatty liver, hepatic fibrosis, cirrhosis and liver cancer, and also relates to a preparation method of a super-concentrated Xianglian product. The Xianglian product has a good anti-Hp effect, and when the Xianglian product is combined with one antibiotic or two antibiotics, the safety of the drugs is improved. The Xianglian product also has the effects of treating or preventing fatty liver, hepatic fibrosis, liver cirrhosis and liver cancer.

Description

technical field [0001] The invention is applied in the technical field of traditional Chinese medicine preparations, and in particular relates to the application of Cyperus chinensis product or its combination with antibiotics in anti-helicobacter pylori drugs. Background technique [0002] Coptis chinensis was first recorded in "Shen Nong's Materia Medica" and listed as top grade. Coptis chinensis is bitter in taste, cold in nature, and has the functions of purging fire, detoxifying, clearing away heat, and drying dampness. For dysphoria, confusion, upset and insomnia, hot and humid fullness, vomiting, abdominal pain and diarrhea, conjunctival congestion and swelling, sore tongue, eczema, burns, vomiting blood, epistaxis, etc. A large number of research results show that Coptidis Rhizome has a strong anti-Helicobacter pylori (HP) effect (Xu Yi et al. Study on the antibacterial effect of single and compound Chinese herbal medicines on Helicobacter pylori, Chinese Journal of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61P31/04A61K31/7048A61K31/43A61K31/422A61K31/5383A61K31/4164A61K31/65A61K31/4439
CPCA61K36/718A61K36/285A61K31/7048A61K31/43A61K31/422A61K31/5383A61K31/4164A61K31/65A61K31/4439A61P31/04A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 叶小利李学刚
Owner 重庆伊士腾生物科技有限公司
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