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Lactoferrin chewing tablet and preparation method thereof

A technology of lactoferrin and chewable tablets, applied in the field of medicine, can solve the problem of no bovine lactoferrin preparation sales, etc., and achieve the effect of no side effects

Inactive Publication Date: 2005-11-02
浙江南洋药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is currently no sales of bovine lactoferrin preparations on the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: In this example, 1,000 chewable lactoferrin tablets were prepared, each weighing 1.5 g, using 1,000 g of lactoferrin, 400 g of sorbitol, 50 g of polyvinylpyrrolidone (PVP), and an appropriate amount of magnesium stearate.

[0012] The preparation is prepared by dry powder tableting method: the above-mentioned amounts of lactoferrin, sorbitol, polyvinylpyrrolidone (PVP) and magnesium stearate are evenly mixed, and directly compressed into tablets.

Embodiment 2

[0013] Example 2: In this example, 1000 chewable lactoferrin tablets were prepared, using 900 g of lactoferrin, 525 g of mannitol, 60 g of polyvinylpyrrolidone (PVP), and an appropriate amount of adipic acid.

[0014] Preparation by wet method: firstly mix lactoferrin and filler mannitol evenly, then add polyvinylpyrrolidone (PVP) and adipic acid, stir evenly, make soft material, granulate, dry, and tablet.

Embodiment 3

[0015] Example 3: In this example, 1000 chewable lactoferrin tablets were prepared, using 1050 g of lactoferrin, 375 g of microcrystalline cellulose, 60 g of spray-dried lactose, and an appropriate amount of sodium lauryl sulfate.

[0016] Prepared by dry granulation and tabletting method: firstly mix lactoferrin with microcrystalline cellulose, spray-dried lactose, and sodium lauryl sulfate, then press it into a solid with suitable equipment, and then crush it into dry granules of appropriate size , and then pressed into pieces.

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PUM

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Abstract

The present invention is chewing tablet of lactoferritin extracted from cow colostrums and its preparation process. The chewing tablet includes lactoferritin in 55-70 wt%, stuffing in 20-50 wt% and adhesive in 0.1-4 wt%, and has excellent effect of radically eliminating Hp and no side effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a chewable tablet of lactoferrin extracted from bovine colostrum and a preparation method thereof. Background technique [0002] Helicobacter pylori (Hp) is a Gram-negative helical microaerophilic bacterium with flagella, which grows and reproduces in the pH environment of the fundus of the human stomach. Infection is associated with varying degrees of various histopathological changes, including chronic active gastritis, trivial gastritis, peptic ulcer, gastric cancer, and gastric mucosa-associated lymphoid tissue (MACT) lymphoma. The current anti-Hp infection treatment plan is "triple" or "quadruple" therapy of bismuth or proton pump inhibitor combined with antibiotics, but due to the side effects of drugs and the rapid increase of drug-resistant strains, some patients fail to treat. Therefore, it is necessary to develop a new drug that can eliminate bacteria and...

Claims

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Application Information

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IPC IPC(8): A61K38/40
Inventor 陈春谢元德马越峰
Owner 浙江南洋药业有限公司
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