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Preparation method of medical polyurethane adhesive with controllable curing time

A polyurethane adhesive and long-term technology, applied in surgical adhesives, applications, medical science, etc., can solve the problems of insufficient adhesion strength, easy to heat and heat, and high price, and achieve adjustable modulus and adhesion High strength and good adaptability

Inactive Publication Date: 2021-07-23
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

α-cyanoacrylate has high adhesion strength and fast curing speed, but it has certain cytotoxicity, it is easy to get hot and hot during use, and it is brittle after curing, making it difficult to adapt to tissues
Fibrin glue has good biocompatibility but lacks adhesion strength and is expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] In the first step, 11.1145g of isophorone diisocyanate (0.05mol, 0.1mol of -NCO) was dissolved in 20mL of tetrahydrofuran, and the 2 , under stirring environment, add it in a round bottom flask; dissolve 15g polyethylene glycol (600Da, 0.025mol, 0.5mol of -OH) in 30ml tetrahydrofuran, and slowly add it into the round bottom flask with isophorone two The isocyanate was reacted for 8 hours at a reaction temperature of 30° C. to obtain an isocyanate group-terminated precursor.

[0022] In the second step, calculate according to the R value (the number of -NCO functional groups in the system: the number of -OH functional groups in the system) = 1.1, dissolve 7.0561g of disuccinimide tartrate (0.0205mol, 0.041mol of -OH) in 20ml of tetrahydrofuran , slowly added to the precursor in the first step, and reacted at 20°C for 5h to obtain a medical polyurethane adhesive containing a solvent.

[0023] In the third step, the product obtained in the second step is transferred to a ...

Embodiment 2

[0025] In the first step, 22.2290g of isophorone diisocyanate (0.1mol, 0.2mol of -NCO) was dissolved in 60mL of tetrahydrofuran, and the 2 1. Add it into a round bottom flask under stirring environment; dissolve 10g polyethylene glycol (200Da, 0.05mol, 0.1mol of -OH) in 30ml tetrahydrofuran, and slowly add it into the round bottom flask with isophorone two The isocyanate was reacted for 4 hours at a reaction temperature of 35° C. to obtain an isocyanate group-terminated precursor.

[0026] In the second step, calculate according to the R value (the number of -NCO functional groups in the system: the number of -OH functional groups in the system) = 1.5, dissolve 5.7137g disuccinimide tartrate (0.0166mol, 0.0332mol of -OH) in 12ml tetrahydrofuran , slowly added to the precursor in the first step, and reacted at 30°C for 6h to obtain a medical polyurethane adhesive containing a solvent.

[0027] In the third step, the product obtained in the second step is transferred to a rotar...

Embodiment 3

[0029] In the first step, 3.4830g toluene diisocyanate (0.02mol, 0.04mol of -NCO) was dissolved in 10mL THF, 2 , Add it into a round bottom flask under stirring environment; dissolve 10g polyethylene glycol (1000Da, 0.01mol, 0.02mol of -OH) in 30ml tetrahydrofuran, and slowly add it to the round bottom flask to react with toluene diisocyanate for 10h , the reaction temperature is 40°C, and the isocyanate group-terminated precursor is obtained.

[0030] In the second step, calculate according to the R value (the number of -NCO functional groups in the system: the number of -OH functional groups in the system) = 1.7, dissolve 0.2642g of tartaric acid (0.0018mol, 0.0036mol of -OH) in 1ml of tetrahydrofuran, and slowly add to The precursor in the first step was reacted at 35° C. for 7 hours to obtain a medical polyurethane adhesive containing a solvent.

[0031] In the third step, the product obtained in the second step is transferred to a rotary evaporator, and rotated at 50° C....

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Abstract

The invention discloses a preparation method of a medical polyurethane adhesive with controllable curing duration, which comprises the following steps: 1) feeding diisocyanate and polyethylene glycol according to a molar ratio of 2: 1 for reaction to obtain an isocyanate-terminated precursor; 2) adding a certain amount of a hydroxyl-terminated chain extender into the precursor obtained in the step 1) according to an R value (the number of-NCO functional groups in the system: the number of -OH functional groups in the system) = 1.1-1.9; and 3) removing the solvent in the product obtained in the step 2) by using a rotary evaporator to finally obtain the isocyanate-terminated medical polyurethane adhesive, and storing the isocyanate-terminated medical polyurethane adhesive in a dry environment for later use. The prepared medical polyurethane adhesive is controllable in curing time, adjustable in modulus, good in biocompatibility, high in adhesion performance and suitable for repairing of different human body soft tissues and hard tissues.

Description

technical field [0001] The invention relates to the technical field of biomedical glue, in particular to a method for preparing a medical polyurethane adhesive with controllable curing time. Background technique [0002] The existing means of repairing human tissue wounds include: surgical sutures, staplers, medical wound dressings, and commercial bioglues. Surgical suture and stapler anastomosis are widely used. Such treatment methods bring a certain degree of pain to the patient, and are prone to leakage of blood and interstitial fluid that damages the tissue. The patient causes secondary injury as well as bacterial infection. Medical wound dressings have low adhesion strength, cannot fully adapt to complex wounds and are prone to bacterial infection. Existing commercial glues mainly include α-cyanoacrylate, fibrin glue and the like. α-cyanoacrylate has high adhesion strength and fast curing speed, but it has certain cytotoxicity, is prone to heat and heat during use, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/66C08G18/48C08G18/34C08G18/32A61L24/00A61L24/04
CPCC08G18/6692C08G18/6666C08G18/4833C08G18/348C08G18/3846A61L24/046A61L24/001C08L75/08
Inventor 施雪涛林佳义宣承楷张照国廖佳宁赖琛
Owner SOUTH CHINA UNIV OF TECH
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