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Synthesis method of potassium trichloroammine platinate

A kind of technology of potassium trichloramplatinate and a synthesis method, which is applied in the field of synthesis of potassium trichloroplatinate, can solve the problems such as difficulty in synthesis of potassium trichloroplatinate and high cost, and achieve short process path, Increased productivity and simple reagents

Active Publication Date: 2021-07-27
内江洛伯尔材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a kind of potassium trichloroplatinate in order to solve the problem that the synthesis of potassium trichloroplatinate is difficult and costly in the prior art The synthetic method, the required raw materials are simple and easy to get, the cost is low, the synthesis conditions are mild, the yield of potassium trichloroplatinate is more than 78%, and the purity is more than 99.5%. It is suitable for industrial production and can be used as an intermediate for the synthesis of methylciplatin and satraplatin and other anticancer drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Synthesis method of a trichloronaminite platinite, including the following steps,

[0037] Step 1: Configure a chloroplatinic acid or a chloride solution to add an acid to adjust the pH to 3 to 7.

[0038] Specifically, 100 g of potassium lipassate solids, 2L deionized water is added, stirred at room temperature, and the solution pH is adjusted to 6.0 with a 10% volume of fractions of acetic acid to 6.0, spare.

[0039] Step 2, slowly, uniformly, quantitatively, a mixture solution of ammonium chloride, alkali metal chloride, and carbonate is quantitatively added to the solution in step 1, and the control temperature is 30 to 70 ° C, and the addition rate is 0.5 to 100 mL / min; After the mixture solution was added, the insulation reaction was continued for 1 to 5 h.

[0040] Specifically, the ammonium chloride 30g, 140 g of potassium chloride, 20 g of potassium carbonate were added, and 300 ml of deionized water was added, and stirred at room temperature. This mixture is ad...

Embodiment 2

[0047] Synthesis method of a trichloronaminite platinite, including the following steps,

[0048] Step 1, 1000 g of potassium acetate solid, 1000 g of 1000 g of deionized water, stirred at room temperature, and adjusted the solution pH to 6.0, spare, using a 10% volume fraction of acetic acid.

[0049] Step 2, 310 g of ammonium chloride, 1300 g of potassium chloride, 210 g of potassium carbonate, add 3,200 ml of deionized water, stirred at room temperature. This mixture was added dropwise to the solution in the above-described step 1, and the entire reaction system was placed in a water bath, controlled at 50 ° C, and the drip speed was controlled at 40 ml / min. After the dropwise addition, the stirring was continued for 2 hours.

[0050] Step 3, the solution after the above reaction was cooled to 4 ° C, a crystalline suspension, filtration, and filtrate transferred into a strong acid type cation exchange resin column to obtain a trichloronaminic acid solution.

[0051] Step 4, ana...

Embodiment 3

[0055] Synthesis method of a trichloronaminite platinite, including the following steps,

[0056] Step 1, the platinum content of 100 g / L was taking a platinumide solution 2L, and the deionized water was diluted to 30 g / L, and the pH of the solution was adjusted to 6.0 with a 10% volume fraction of acetic acid.

[0057] Step 2, 130 g of ammonium chloride, 570 g of potassium chloride, 100 g of potassium carbonate, add 1500 ml of deionized water, stirred at room temperature. This mixture was added dropwise to the solution in the above step 1, and the entire reaction system was placed in a water bath, controlled at 50 ° C, and the drip speed was controlled at 20 ml / min. After the dropwise addition, the stirring was continued for 2 hours.

[0058] Step 3, the solution after the above reaction was cooled to 4 ° C, a crystalline suspension, filtration, and filtrate transferred into a strong acid type cation exchange resin column to obtain a trichloronaminic acid solution.

[0059]...

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Abstract

In order to solve the problems of high synthesis difficulty and high cost of potassium trichloroammine platinate in the prior art, the invention discloses a synthesis method of potassium trichloroammine platinate. The method comprises the following steps: by taking chloroplatinous acid or chloroplatinite, ammonium chloride, alkali chloride and carbonate as raw materials, adjusting the pH value of a system to prepare a trichloroammine complexed platinic acid solution, and thenpreparing trichlorine complex potassium platinatefrom the trichlorine complex platinum acid and potassium chloride. According to the synthesis method of the potassium trichloroammine platinate, the required raw materials are simple and easy to obtain, the cost is low, the synthesis conditions are mild, the yield of the potassium trichloroammine platinate is 78% or above, and the potassium trichloroammine platinate can be used as an intermediate for synthesizing anti-cancer drugs such as picoplatin and satraplatin and is suitable for industrial production.

Description

Technical field [0001] The present invention relates to the field of chemical technology, and more particularly to a synthesis method of potassium trichloronaminic acid. Background technique [0002] Potassium trichloride plascate is used as an intermediate, commonly used in anticancer drugs such as synthetic platinum and Celite. Among them, Selite is the first platinum group metal anti-tumor drug with oral active, and there is no cross resistance with cisplatin. However, but the synthesis difficulty of platinaceous sour tachopassium trichloride is high, and the scale production cost is very high. [0003] Currently, typical synthesis programs for potassium trichloride plasma have: [0004] 1. Prior art (J. Med. Chem. 1992, 35 (24), 4531) is disclosed, and the platinum and a small amount of solid platinum powder are refluxed in concentrated hydrochloric acid at 6 mol / L, and cool to 0 ° C, remove Solid cisplatin, then reinolubate the filtrate into a concentrated hydrochloric aci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G55/00
CPCC01G55/002C01G55/001C01P2006/80
Inventor 杨辅龙苏阿敏李正国陈永雄陈嶷韬
Owner 内江洛伯尔材料科技有限公司
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