Unlock instant, AI-driven research and patent intelligence for your innovation.

Anti-inflammatory analgesic external preparation

A technology of external preparations and compositions, applied in the direction of anti-inflammatory agents, non-central analgesics, anesthetics, etc., which can solve the problems of unrevealed lidocaine lactate, low solvent solubility, and lack of efficacy , to achieve good skin permeability, pain relief, storage stability and safety improvement

Pending Publication Date: 2021-07-30
MEDRX CO LTD
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diclofenac sodium, which is one of the general-purpose nonsteroidal anti-inflammatory analgesics, has the following problems: its solubility in solvents is low, and it is difficult to manufacture it as an external preparation such as a patch. Even if it can be manufactured in the form of an external preparation Under this condition, diclofenac will not fully penetrate the skin and will not be effective
However, Patent Document 6 neither discloses nor suggests the use of lactic acid and alkali metal salts or alkaline earth metal salts of lactic acid to prepare lidocaine lactate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-inflammatory analgesic external preparation
  • Anti-inflammatory analgesic external preparation
  • Anti-inflammatory analgesic external preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1~4

[0120] Each component was weighed at the contents shown in Table 1 below to prepare the preparations of Examples 1-4. Specifically, styrene-isoprene-styrene block copolymer (SIS) and terpene resin were dissolved in toluene by a solvent method, and then 1) liquid paraffin, 2) lactic acid, sodium lactate, and nutmeg were sequentially added 3) lidocaine, and lidocaine and lactic acid components form ion pairs to generate lidocaine lactate which is liquid at normal temperature, and diclofenac sodium is added and mixed. Next, the mixture was applied to a silicone-coated PET film, dried, and the toluene was removed, and the mixture was pasted on a support, and cut into 7 cm×10 cm to prepare a formulation.

[0121]

Embodiment 5~9

[0123] Each component was weighed at the content shown in the following Table 2, and the formulations of Examples 5-9 were prepared. Specifically, styrene-isoprene-styrene block copolymer (SIS) and terpene resin were dissolved in toluene by a solvent method, and then 1) liquid paraffin, 2) dibutylhydroxytoluene ( BHT) and butyl hydroxyanisole (BHA), 3) lactic acid, sodium lactate and isopropyl myristate, 4) lidocaine, and make lidocaine and lactic acid form an ion pair to form a liquid at room temperature After the lidocaine lactate, add diclofenac sodium and mix. Next, the mixture was applied to a silicone-coated PET film, dried, and the toluene was removed, and the mixture was pasted on a support, and cut into 7 cm×10 cm to prepare a formulation.

[0124]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides: an external preparation composition including lidocaine lactate that is composed of lidocaine and a lactic acid component, and diclofenac or a salt thereof, wherein the lactic acid component is composed of a lactic acid and an alkaline-earth metal salt or an alkali metal salt of lactic acid; and an external preparation that demonstrates excellent transdermal absorption of both lidocaine and diclofenac, that realizes cutaneous permeability suitable for clinical use, and further, that exhibits improved storage stability and safety, allowing for a long shelf life.

Description

technical field [0001] (Cross References to Related Applications) [0002] This application claims priority based on Japanese Application No. 2018-237691 filed on December 19, 2018 (the entirety of which is made a part of this specification based on the source description). [0003] The present invention relates to an external preparation comprising lidocaine and diclofenac or a salt thereof as active ingredients. More specifically, it relates to an external preparation composition comprising an equimolar salt of a lidocaine-lactic acid component (lidocaine lactate) and diclofenac or a salt thereof, and an external preparation comprising the same, and an external preparation comprising the same. It is an alkali metal or alkaline earth metal salt of lactic acid and lactic acid. Background technique [0004] Various external preparations containing a non-steroidal anti-inflammatory analgesic and a local anesthetic have been proposed (Patent Documents 1 to 5). Diclofenac sod...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/167A61K31/196A61P23/02A61P29/00A61P43/00A61K9/70A61K47/10A61K9/00A61K47/12A61K47/14
CPCA61K31/167A61P29/00A61P43/00A61K47/10A61K47/12A61K47/14A61K31/196A61P23/02A61K9/0014A61K47/22A61K9/7053A61K47/44A61K47/20A61K47/186A61K47/02A61K9/06A61K9/12A61K2300/00
Inventor 川原遥华石桥贤树滨本英利
Owner MEDRX CO LTD