Modified polyetheretherketone as well as preparation method and application thereof

The technology of polyetheretherketone and sulfonated polyetheretherketone is applied in the field of modified polyetheretherketone and its preparation, and can solve the problems of limited improvement of biological activity, decreased mechanical properties, unfavorable performance of polyetheretherketone, etc. Achieve the effect of inducing osteogenic differentiation of stem cells, good biological activity and osteoinductive ability

Active Publication Date: 2021-08-03
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyether ether ketone has become an excellent choice for orthopedic implant materials because of its mechanical properties close to bone, radiolucency, and good thermoplasticity; however, polyetheretherketone is biologically inert and cannot be combined with bone. The tissue forms a good integration, and the implant cannot form a continuous structure with the bone tissue and perform continuous functions when it is implanted in the organism; therefore, it needs to be modified to enhance its biological activity
[0003] In the related research field of polyetheretherketone, the biological activity of its surface can be significantly improved by blending and surface modification; however, the blending method is easy to cause Its mechanical properties decrease, which is not conducive to the performance of polyether ether ketone itself; currently, it is a common method to use concentrated sulfuric acid to sulfonate it to change the physical and chemical properties of its surface; however, only by sulfonating its surface Therefore, how to modify PEEK on the basis of sulfonated PEEK to improve its practical application value is still one of the important topics for researchers in this field.

Method used

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  • Modified polyetheretherketone as well as preparation method and application thereof
  • Modified polyetheretherketone as well as preparation method and application thereof
  • Modified polyetheretherketone as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] The preparation method of the modified polyether ether ketone provided in this embodiment comprises the following steps:

[0041] 1. Sulfonation: Add concentrated sulfuric acid to the polyetheretherketone sheet for sulfonation. The sulfonation time is 3 minutes to obtain sulfonated polyetheretherketone. Based on the mass of 1g of polyetheretherketone sheet, the concentrated The amount of sulfuric acid used is not less than 100mL;

[0042] 2. Active treatment: add sulfonated polyether ether ketone to bioglass sol for 5 minutes, take it out and dry it, and repeat this action three times; based on the mass of 1g polyetheretherketone sheet, the bioglass The amount of sol used is 50mL;

[0043] 3. Heat treatment: Heat treatment at 120°C for 24 hours to obtain modified polyether ether ketone.

[0044] The biological glass sol in the present embodiment adopts calcium source, silicon source, magnesium source, obtains biological glass sol by sol-gel method under acidic conditi...

Embodiment 2

[0060] The preparation method of the modified polyether ether ketone provided in this embodiment comprises the following steps:

[0061] 1. Sulfonation: Add concentrated sulfuric acid to the polyetheretherketone sheet for sulfonation. The sulfonation time is 3 minutes to obtain sulfonated polyetheretherketone. Based on the mass of 1g of polyetheretherketone sheet, the concentrated The amount of sulfuric acid used is not less than 100mL;

[0062] 2. Active treatment: add sulfonated polyether ether ketone to bioglass sol for 5 minutes, take it out and dry it, and repeat this action three times; based on the mass of 1g polyetheretherketone sheet, the bioglass The amount of sol used is 50mL;

[0063] 3. Heat treatment: Heat treatment at 150°C for 24 hours to obtain modified polyether ether ketone.

[0064] The biological glass sol in the present embodiment adopts calcium source, silicon source, magnesium source, obtains biological glass sol by sol-gel method under acidic conditi...

Embodiment 3

[0066] The preparation method of the modified polyether ether ketone provided in this embodiment comprises the following steps:

[0067] 1. Sulfonation: Add concentrated sulfuric acid to the polyetheretherketone sheet for sulfonation. The sulfonation time is 3 minutes to obtain sulfonated polyetheretherketone. Based on the mass of 1g of polyetheretherketone sheet, the concentrated The amount of sulfuric acid used is not less than 100mL;

[0068] 2. Active treatment: add sulfonated polyether ether ketone to bioglass sol for 5 minutes, take it out and dry it, and repeat this action three times; based on the mass of 1g polyetheretherketone sheet, the bioglass The amount of sol used is 50mL;

[0069] 3. Heat treatment: Heat treatment at 120°C for 24 hours to obtain modified polyether ether ketone.

[0070] The biological glass sol in the present embodiment adopts calcium source, silicon source, magnesium source, obtains biological glass sol by sol-gel method under acidic conditi...

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Abstract

The invention discloses modified polyetheretherketone, a preparation method thereof and application of the modified polyetheretherketone in preparation of products for inducing formation of bone-like apatite or products for inducing osteogenic differentiation of stem cells. The preparation method of the modified polyetheretherketone comprises the following steps: sulfonating a polyetheretherketone sheet with concentrated sulfuric acid, and then conducting soaking in water to obtain sulfonated polyetheretherketone; treating the sulfonated polyetheretherketone in bioglass sol, and then conducting heat treatment to obtain modified polyetheretherketone. The modified polyetheretherketone provided by the invention has good mechanical properties and good life compatibility, can slowly release functional elements, and has good biological activity and bone induction ability; and functional ions can be released to induce osteogenic differentiation of stem cells.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a modified polyetheretherketone and its preparation method and application. Background technique [0002] Polyether ether ketone is a special polymer material, which has been widely used in industry, aerospace and other fields due to its excellent thermodynamic properties. Polyether ether ketone has become an excellent choice for orthopedic implant materials because of its mechanical properties close to bone, radiolucency, and good thermoplasticity; however, polyetheretherketone is biologically inert and cannot be combined with bone. The tissue is well integrated, and the implant cannot form a continuous structure with the bone tissue and perform continuous functions when it is implanted in the organism; therefore, it needs to be modified to enhance its biological activity. [0003] In the research field of PEEK, the biological activity of its surface can be significantly improv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/06C08J7/14A61L27/18A61L27/30A61L27/50A61L27/56
CPCC08J7/14C08J7/06A61L27/18A61L27/306A61L27/50A61L27/56C08J2361/16A61L2400/18A61L2420/02A61L2300/602C08L61/16
Inventor 王友张珏苑志国
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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