Application of small molecule compound in preparation of medicine for resisting central nervous system inflammation

A technology of small molecular compounds and central nervous system, applied in the field of medicine, can solve the problems of large side effects, unsatisfactory drug requirements, poor specificity of MIF inhibitor NAPQI, etc., and achieves the effect of low cytotoxicity and good development prospects.

Pending Publication Date: 2021-08-06
SUZHOU UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

The first discovered MIF inhibitor NAPQI has poor specificity and side effects
The pharmacokine

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  • Application of small molecule compound in preparation of medicine for resisting central nervous system inflammation
  • Application of small molecule compound in preparation of medicine for resisting central nervous system inflammation
  • Application of small molecule compound in preparation of medicine for resisting central nervous system inflammation

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[0015] In order to make the above objects, features, and advantages of the present invention, the technical solutions of the present invention will be further described below in connection with the embodiments. However, the invention is not limited to the listed embodiments, and should also be included in any other known changes within the scope of the claims.

[0016] The "one embodiment" or "Embodiment" herein refer to specific features, structures, or characteristics that can be included in at least one implementation of the present invention. The "in one embodiment" in one embodiment in this specification is not all referred to, nor, not separate or selective embodiments with other embodiments.

[0017] The present invention found that small molecule compounds (E) -5- (5- ((2- (4-amino-4 hydrogen-1,2,4-triazole-3-yl) were found by molecular docked software. Sany-methyl) furan-2-yl) -2-chlorobenzoic acid (hereinafter referred to as compound # 12) may have MIF tautomogenease inh...

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Abstract

The invention discloses an application of a small molecule compound, the small molecule compound is (E)-5-(5-((2-(4-amino-4-hydro-1, 2, 4-triazole-3-yl) hydrazine subunit) methyl) furan-2-yl)-2-chlorobenzoic acid, the chemical structural formula of the small molecule compound is shown in the specification, the small molecule compound has a relatively strong inhibition effect on MIF, has an obvious inhibition effect on microglial cell activation-mediated NO release, and can be used for preparing a medicine for treating microglial cells. And the small molecule compound is relatively low in cytotoxicity, has a very good development prospect, is expected to be developed into a novel MIF inhibitor, and is expected to be developed into a novel medicine for resisting central system inflammation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the application of a small molecular compound in the preparation of MIF inhibitors and anti-inflammation drugs of the central nervous system. Background technique [0002] Immune dysregulation in the central nervous system is a key factor in the development of various nervous system diseases. Microglia are the main immune cells of the nervous system, and they serve as the first line of defense to monitor stimuli such as pathogen infection and neuron damage at any time. Resting microglia can be activated into classically activated M1 or selectively activated M2. M1 microglia secrete iNOS, TNF-α, ROS and other pro-inflammatory factors, which play an important role in the clearance of pathogens in the brain. M2 microglia secrete IL-10, TGF-α and other anti-inflammatory factors to reduce inflammation and promote tissue repair. Inflammatory activation of microglia and c...

Claims

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Application Information

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IPC IPC(8): A61K31/4196A61P25/00A61P29/00
CPCA61K31/4196A61P25/00A61P29/00
Inventor 镇学初田盛刘纯
Owner SUZHOU UNIV
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