Drug-loaded degradable and absorbable medical suture and preparation method thereof

A suture and drug-carrying technology, applied in the field of medical sutures, can solve the problems of easily leaving suture scars, ordinary silk threads cannot be automatically degraded, and large toxic and side effects, achieving easy processing and control, easy in vitro degradability, good The effect of biocompatibility

Active Publication Date: 2021-08-27
QINGDAO TECHNOLOGICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the sutures currently on the market have the following problems: 1. The direct use of drugs brings disadvantages such as poor selectivity, large toxic and side effects, fast metabolism, short half-life, and poor stability; 2. Ordinary silk threads cannot be automatically degraded and are on

Method used

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  • Drug-loaded degradable and absorbable medical suture and preparation method thereof
  • Drug-loaded degradable and absorbable medical suture and preparation method thereof
  • Drug-loaded degradable and absorbable medical suture and preparation method thereof

Examples

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Embodiment Construction

[0040] The specific implementation manners of the present application will be further described in detail below in conjunction with the embodiments. The following examples are used to further explain the present application, but are not used to limit the scope of the present application.

[0041] As shown in the accompanying drawings, the present application provides a drug-loaded degradable absorbable medical suture and its preparation method. The lubricating layer 4 is composed of; lactic acid-based silk thread 1 is made of polylactic acid-glycolic acid (PLGA) material formed by the thermal condensation of oligomeric lactic acid-glycolic acid synthesized by L-lactic acid aqueous solution and glycolic acid aqueous solution; the drug-loaded protein is hydrocoagulated Gel 2 is a gel prepared by mixing protein water dissolved in natural silk with beneficial drugs (aspirin, dexamethasone, etc.); the beneficial drugs such as amoxicillin and phensulfame are emulsified and dissolved...

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Abstract

The invention discloses a drug-loaded degradable and absorbable medical suture and a preparation method thereof. According to the suture, a polylactic acid-based material serves as a silk thread base body, the silk thread base body, a middle drug-loaded layer and an outer lubricating layer are bonded into a whole through drug-loaded protein hydrogel, and the suture is prepared through a special synthesis technology; the prepared suture can effectively control the degradation and absorption period in the human skin; the innovative combination of the polylactic acid silk thread base body and the drug-loaded coating layer can effectively improve the antibacterial, hemostatic and anti-inflammatory effects of the suture; and the outer lubricating layer can effectively improve the lubricity of the suture, reduce the pain of a patient in the operation process and improve the operation operability. The raw materials of the suture can be degraded and absorbed and have good biocompatibility and physiological activity, and the preparation method is simple in process, convenient to operate, wide in raw material source, and good in application prospects.

Description

technical field [0001] The present application relates to medical sutures in the medical field, in particular to a drug-loaded degradable absorbable medical suture and a preparation method thereof. Background technique [0002] Medical surgical suture is a kind of sterile thread used for wound healing, tissue ligation and tissue fixation, and plays an important role in the initial healing of wounds. However, the sutures currently on the market have the following problems: 1. The direct use of drugs brings disadvantages such as poor selectivity, large toxic and side effects, fast metabolism, short half-life, and poor stability; 2. Ordinary silk threads cannot be automatically degraded and are only used on the external skin of the wound. 3. The existing non-biodegradable sutures have poor degradation effect, poor compatibility, cannot be completely absorbed, and easily leave suture scars; 4. People have higher and higher requirements for the aesthetics and health of sutured w...

Claims

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Application Information

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IPC IPC(8): A61L17/10A61L17/12A61L17/14A61L17/00
CPCA61L17/12A61L17/10A61L17/145A61L17/005A61L2300/222A61L2300/216A61L2300/41A61L2300/404A61L2300/406A61L2300/604C08L67/04C08L89/00
Inventor 莫火萍马衍轩许佳孙冰洁葛景跃赵洁韩云鹏于霞
Owner QINGDAO TECHNOLOGICAL UNIVERSITY
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