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Preparation method of anti-phlegm embolus tracheal catheter loaded with hydrogel coating

An endotracheal tube and hydrogel technology, which can be used in catheters, coatings, pharmaceutical formulations, etc., can solve the problems of reducing the probability of ventilator-related pneumonia, easy blockage and reduction of endotracheal tubes, and reduce cell adhesion and protein. Good adsorption and biocompatibility

Active Publication Date: 2021-09-07
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the defect of prior art, provide a kind of preparation method of the anti-phlegm embolism endotracheal tube of load hydrogel coating, adopt hydrogel coating to solve the easy clogging problem of endotracheal tube; Due to the hydrophilic and water-locking properties of the coating, sputum will flow down to the lungs along the hydrogel coating of the endotracheal tube, which will not cause sputum to adhere and gather or even dry out to block the tube; while the endotracheal tube is unobstructed, bacteria are reduced The colonization of biofilm can inhibit the formation of biofilm, so the probability of ventilator-associated pneumonia can be greatly reduced

Method used

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Embodiment Construction

[0024] In order to enable those skilled in the art to better understand the technical solution of the present invention, its specific implementation is described in detail below:

[0025] In an embodiment of the present invention, a method for preparing an anti-phlegm embolism endotracheal tube loaded with a hydrogel coating comprises the following steps:

[0026] S1, the sterilized endotracheal tube is cleaned with isopropanol and deionized water in sequence, and after drying, the inner wall of the endotracheal tube is treated with plasma or ozone;

[0027] S2, immerse the endotracheal tube treated in step S1 into an isopropanol solution containing a hydrophobic photoinitiator for swelling treatment for 1 to 5 minutes, and form a swelling adhesion layer on the inner wall of the endotracheal tube; the hydrophobic photoinitiator is benzophenone, hydrophobic The mass concentration of photoinitiator in isopropanol is 3wt%~10wt%,

[0028] S3, fix an omnidirectional ultraviolet li...

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Abstract

The invention discloses a preparation method of an anti-phlegm embolus tracheal catheter loaded with a hydrogel coating. The hydrogel coating is adopted to solve the problem that the tracheal catheter is easy to block. Due to the hydrophilic and water-locking characteristics of the hydrogel coating, phlegm can move downwards to the lung along the hydrogel coating of the tracheal catheter, and the situation that the catheter is blocked due to adhesion, aggregation and even dryness of the phlegm is avoided; and when the tracheal catheter is smooth, colonization of bacteria is reduced, so that formation of a biological membrane can be inhibited, and the probability of occurrence of ventilator-related pneumonia can be greatly reduced.

Description

technical field [0001] The invention relates to a preparation method of an anti-phlegm embolism endotracheal tube loaded with a hydrogel coating. Background technique [0002] Endotracheal intubation refers to the insertion of a tracheal tube into the patient's trachea through the oral or nasal cavity. It is a common clinical technique for endotracheal anesthesia and patient rescue, and it is also the most reliable means to keep the upper airway open. However, endotracheal intubation breaks the normal airway structure, damages the airway mucosa, and reduces its ability to clear secretions; at the same time, it weakens the patient's cough and swallowing reflex, and oropharyngeal secretions seep into the lower airway. The resulting risks associated with mechanical ventilation include ventilator-associated pneumonia and tracheal tube obstruction, two common complications. [0003] Clinically, secretions accumulate in the catheter lumen within hours of intubation, and significa...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14C08F120/06C08F120/54C08F2/48
CPCA61L29/085A61L29/08A61L29/145C08F120/06C08F120/54C08F2/48A61L2400/18A61L2420/02A61L2420/08C08L33/02C08L33/24C08F2500/26
Inventor 姜虹王刚蔡秉岳孙宇王越
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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