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Preparation method of high internal phase emulsion with self-stabilization capability

A high internal phase emulsion and self-stabilizing technology, which is applied in the fields of pharmaceuticals, food, and cosmetic preparations, and can solve problems such as limited stabilization effects and complicated processes

Active Publication Date: 2021-09-10
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In summary, the commonly used stabilizers for Pickeringo internal phase emulsions are: cellulose, chitin, starch nanocrystals, protein-based colloidal particles, protein-polysaccharide mixed particles-protein-polyphenol mixed particles and the latest many balls Protein, etc., but they all need to introduce other substances from the outside world, the process is complicated, and the final stabilization effect is limited

Method used

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  • Preparation method of high internal phase emulsion with self-stabilization capability

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Effect test

Embodiment 1

[0025] The preparation method of the high internal phase emulsion 1 with self-stabilizing ability, comprises the following steps:

[0026] 1) Under the conditions of a water bath with a temperature of 70°C and a stirring speed of 300 rpm, 0.1 g of nobiletin was supersaturated dissolved in 15 ml of medium-chain triglycerides to form a nobiletin-medium-chain triglyceride solution (fat mixture) as an oil phase;

[0027] 2) 3-propanesulfonic acid buffer solution with pH=7.4 is used as the water phase, and 15ml of the oil phase is mixed with 5ml of the water phase to obtain an oil-water mixture; and in the oil-water mixture, the oil phase accounts for 75% of the total volume;

[0028] 3) Cut the oil-water mixture for 2 minutes at a rotational speed of 10,000 rpm, then add 3 mg of tannic acid powder and 0.49 mg of ferric chloride hexahydrate powder to the oil-water mixture; continue to cut for 3 minutes to obtain a high internal phase emulsion 1; wherein, In high internal phase emu...

Embodiment 2

[0030] The preparation method of the high internal phase emulsion 2 with self-stabilizing ability, comprises the following steps:

[0031] 1) Under the conditions of a water bath with a temperature of 70°C and a stirring speed of 300rpm, 0.2g of nobiletin was supersaturatedly dissolved in 15ml of medium-chain triglycerides to form a nobiletin-medium-chain triglyceride solution (fat mixture) as an oil phase;

[0032] 2) 3-propanesulfonic acid buffer solution with pH=7.4 is used as the water phase, and 15ml of the oil phase is mixed with 5ml of the water phase to obtain an oil-water mixture; and in the oil-water mixture, the oil phase accounts for 75% of the total volume;

[0033] 3) Cut the oil-water mixture for 2 minutes under the condition that the rotating speed is 10000 rpm, and then add 3 mg of tannic acid powder and 0.49 mg of ferric chloride hexahydrate powder to the oil-water mixture; continue to cut for 3 minutes to obtain high internal phase emulsion 2; , high intern...

Embodiment 3

[0035] The preparation method of the high internal phase emulsion 3 with self-stabilizing ability, comprises the following steps:

[0036] 1) Under the conditions of a water bath with a temperature of 70° C. and a stirring speed of 300 rpm, 0.2 g of nobiletin was supersaturated dissolved in 16 ml of medium-chain triglycerides to form a nobiletin-medium-chain triglyceride solution (fat mixture) as an oil phase;

[0037] 2) 3-propanesulfonic acid buffer solution with pH=7.4 is used as the water phase, and 16ml of the oil phase is mixed with 4ml of the water phase to obtain an oil-water mixture; and in the oil-water mixture, the oil phase accounts for 80% of the total volume;

[0038] 3) Cut the oil-water mixture for 2 minutes at a rotational speed of 10000 rpm, then add 2.4 mg of tannic acid powder and 0.39 mg of ferric chloride hexahydrate powder to the oil-water mixture; continue to cut for 3 minutes to obtain high internal phase emulsion 3; Among them, in the high internal p...

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Abstract

The invention discloses a preparation method of a high internal phase emulsion with self-stabilization capability. The preparation method comprises the following steps of firstly, dissolving a hydrophobic and easy-to-crystallize medicine in grease in a supersaturated manner under the conditions of high temperature and stirring; obtaining a grease mixture; uniformly mixing the grease mixture with a buffer solution with the pH value of 7-8 to obtain an oil-water mixture; in the high-speed shearing process, adding a polyphenol organic coordination substance an inorganic metal ion cross-linking agent into the oil-water mixture; and uniformly shearing to obtain the high internal phase emulsion. The high-internal-phase emulsion with self-stabilization capability provided by the invention can be stably stored for six months at room temperature, while a common high-internal-phase emulsion can only be stabilized for about three months. Compared with a common emulsion, the one-step preparation method is simpler, more convenient and faster, and is suitable for industrial expanded production.

Description

technical field [0001] The invention relates to the fields of food, medicine and cosmetic preparations, in particular to a preparation method of a high internal phase emulsion with self-stabilizing ability. Background technique [0002] Natural functional factors have a wide range of biological activities, such as anti-oxidation, anti-inflammation, anti-aging, anti-Alzheimer's disease, anti-cancer, etc., so they are often used in food, medicine and cosmetic preparations. However, there is a class of hydrophobic and easily crystalline substances such as nobiletin, which has strong hydrophobicity and is easy to crystallize because of its polymethoxyl group in its chemical structure, poor storage stability and low bioavailability after oral administration, which eventually leads to industrial It is difficult to process and the human body cannot absorb and utilize its active effects. [0003] Therefore, scientists in the field of utilization of hydrophobic and easy-to-crystalli...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/352A61K47/02A61K47/14A61K47/22A61K47/26A61K47/44A61P39/06A61P17/16
CPCA61K9/107A61K31/352A61K47/44A61K47/14A61K47/26A61K47/22A61K47/02A61P39/06A61P17/16
Inventor 梁宏闪王欣艺李斌王凌周彬崔冰王悦明
Owner HUAZHONG AGRI UNIV
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