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Combined solvent as well as preparation method and application thereof

A solvent and drug solution technology, which can be used in antiviral agents, pharmaceutical formulations, medical preparations with inactive ingredients, etc., and can solve problems such as intolerance, stinging, and reduced safety.

Pending Publication Date: 2021-09-10
上海和绎实业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the water-insoluble drugs (such as nucleoside drugs) in the prior art that cannot be dissolved in neutral solvents such as water, but can only be dissolved in strong acid (alkali) or oily solvents, resulting in safety Reduce and cause side effects such as stinging pain, ulceration at the injection site, intolerance, and drug withdrawal, and the high proportion of oily solvents in strong acidic or alkaline solvents leads to injection pain, and the syringe is difficult to extract. The invention provides A combined solvent, a drug solution containing the same, and a preparation method and application thereof

Method used

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  • Combined solvent as well as preparation method and application thereof
  • Combined solvent as well as preparation method and application thereof
  • Combined solvent as well as preparation method and application thereof

Examples

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Embodiment 1

[0073] 1. Preparation of drug solution:

[0074] a. Before solvent configuration, high-temperature sterilization of all experimental materials and reagents of solvent components (because antiviral drugs for the treatment of feline infectious peritonitis require subcutaneous injection to achieve maximum bioavailability and fastest onset of effect, so aseptic processing is a necessary step);

[0075] b. The dry powder of the drug GS 441524 is dissolved in a solvent (the solvent formula is shown in Table 2 below). After the drug is completely dissolved, the solution can be stored and injected at room temperature;

[0076] c. After the dissolved solution was placed in the temperature range of -20°C to 80°C, no drug precipitation was found and the state of the drug was stable (see Table 2 below for details);

[0077] d. The concentration of the drug in the solution after dissolution is ≥15mg / ml.

[0078] Among them, the solvent preparation steps include: adding DMSO to the drug G...

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Abstract

The invention provides a combined solvent. The combined solvent comprises DMSO, liquid PEG and water, the content of the DMSO is 5%-10%, the content of the liquid PEG is 65%-95%, the content of the water is 0%-25%, and the percentage is the volume percentage of each component in the combined solvent. The invention also provides a medicine solution containing the combined solvent and application of the medicine solution. The combined solvent disclosed by the invention is a neutral solvent, so that the combined solvent is safer than a strong acid (alkali) solvent, and has no side effects such as stabbing pain and ulceration; and the proportion of an oily solvent in the combined solvent is less, so that the pain can be reduced when the combined solvent is used for injection, the combined solvent is more suitable for injection, and the combined solvent is easier to extract and push during syringe injection. When the medicine dissolved by the combined solvent is used for treatment, the curative effect of the medicine is not changed, and the absorption of the medicine is promoted so as to increase the curative effect of the medicine. In addition, the combined solvent does not need to be stored under special pH and temperature conditions, and is stable and easy to store.

Description

technical field [0001] The invention relates to a combined solvent and its preparation method and application, in particular to a combined solvent for dissolving water-insoluble drugs (such as nucleoside drugs) and its preparation method and application. Background technique [0002] There are many water-insoluble drugs in the prior art, which are generally prepared into tablets for oral use, or are dissolved in oily solvents. Among them, nucleoside drugs are an important class of drugs used clinically to treat viral infectious diseases, tumors, and AIDS. Nearly 50% of the currently used antiviral drugs are nucleoside drugs, and the antineoplastic drugs Cytarabine, Doxifluridine, etc. also belong to the nucleoside drugs. Most nucleoside drugs are almost insoluble in water, such as the nucleoside drugs disclosed in PCT patent application PCT / US2018 / 022166: nitrogen-containing sugar nucleoside analogs or pharmaceutically acceptable salts thereof, which do not specify The sol...

Claims

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Application Information

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IPC IPC(8): A61K47/20A61K47/10A61K31/706A61P31/14
CPCA61K47/20A61K47/10A61K31/706A61P31/14
Inventor 冯晗
Owner 上海和绎实业有限公司
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