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Preparation method of granules for treating infantile lung heat cough and asthma

A technology for Feire Kechuan and granules, which is applied in the field of preparation of Feire Kechuan granules for children

Active Publication Date: 2021-09-14
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it only improved the stability of ephedra content and baicalin content respectively, and did not involve the study of grain taste

Method used

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  • Preparation method of granules for treating infantile lung heat cough and asthma
  • Preparation method of granules for treating infantile lung heat cough and asthma
  • Preparation method of granules for treating infantile lung heat cough and asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A preparation method of Xiaoer Feire Kechuan Granules, which comprises weighing the following Chinese medicinal materials:

[0020] S1 weighed 2400g of raw gypsum, 1000g of Radix Radix, 1000g of Ophiopogon japonicus and 1000g of Houttuynia cordata according to the mass ratio of 24:10:10:10, crushed, and passed through 70 meshes to obtain a mixed crushed product;

[0021] S2 According to the mass ratio of 3:10:6:10, weigh 300g of licorice, 1000g of honeysuckle, 600g of bitter almond and 1000g of Anemarrhena, add 11600g of 50℃ water to soak for 2h, heat to 80℃ for the first boiling for 1h , during the boiling process, add the mixed pulverized material of step S1 and 16200 g of 80°C water, stir evenly, let stand for 2 hours after boiling, and then heat to 90°C for a second boiling for 2 hours, cool, and filter to obtain filtrate 1;

[0022] S3 weighed 300g of ephedra, 1000g of forsythia and 1000g of Scutellaria baicalensis according to the mass ratio of 3:10:10, added 13,8...

Embodiment 2

[0027] A preparation method of Xiaoerfeirekechuan granules, prepared according to the following steps:

[0028] S1 weighed 2400g of raw gypsum, 1000g of Radix Radix, 1000g of Ophiopogon japonicus and 1000g of Houttuynia cordata according to the mass ratio of 24:10:10:10, crushed, and passed through 70 meshes to obtain a mixed crushed product;

[0029] S2 According to the mass ratio of 3:10:6:10, weigh 300g of licorice, 1000g of honeysuckle, 600g of bitter almond and 1000g of Zhimu, add 17400g of 60℃ water to soak for 4 hours, heat to 90℃ for the first boiling 2h, during the cooking process, add the mixed pulverized product of step S1 and 27000g of 90°C water, stir evenly, let stand for 4h after boiling, and then heat to 95°C for the second boiling for 4h, cool and filter to obtain the filtrate 1 ;

[0030] S3 weighed 300g of ephedra, 1000g of forsythia and 1000g of Scutellaria baicalensis according to the mass ratio of 3:10:10, added 18400g of 80°C water, let it stand for 4h,...

Embodiment 3

[0035] A preparation method of Xiaoerfeirekechuan granules, prepared according to the following steps:

[0036] S1 weighed 2400g of raw gypsum, 1000g of Radix Radix, 1000g of Ophiopogon japonicus and 1000g of Houttuynia cordata according to the mass ratio of 24:10:10:10, crushed, and passed through 70 meshes to obtain a mixed crushed product;

[0037] S2 According to the mass ratio 3:10:6:10, weigh 300g of licorice, 1000g of honeysuckle, 600g of bitter almond and 1000g of Anemarrhena, add 14500g of 55℃ water to soak for 4 hours, heat to 80℃ for the first boiling 3h, add the mixed powder of step S1 and 21600g of 85°C water during the boiling process, stir evenly, let stand for 3h after boiling, then heat to 90°C for the second boiling for 3h, cool, filter, and obtain the filtrate 1 ;

[0038]S3 weighed 300g of ephedra, 1000g of forsythia and 1000g of scutellaria baicalensis according to the mass ratio of 3:10:10, added 18400g of 80°C water, let stand for 3h, heated to 92°C for...

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Abstract

The invention provides a preparation method of granules for treating infantile lung heat cough and asthma. The preparation method comprises the following steps of: (1) adding liquorice, honeysuckle, semen armeniacae amarae and rhizoma anemarrhenae into hot water for soaking, adding crushed materials of gypsum, radix isatidis, radix ophiopogonis and houttuynia cordata in the boiling process, and filtering after boiling to obtain filtrate 1; (2) crushing ephedra, fructus forsythiae and scutellaria baicalensis, adding hot water for soaking, and filtering after repeated boiling to obtain filtrate 2; (3) performing vacuum concentration on the filtrate 1 and the filtrate 2 to obtain clear paste 1 and clear paste 2, adding mannitol into the clear paste 1, and refrigerating for a long time; and (4) mixing the clear paste 1 and the clear paste 2, preheating with hot air, performing spray drying, adding sodium cyclamate powder, and drying with hot air to obtain the granules. The granules for treating infantile lung heat cough and asthma prepared by the method provided by the invention have fresh and sweet taste, good stability, high content of effective components and good curative effect.

Description

technical field [0001] The invention relates to the field of preparation of pharmaceutical preparations, in particular to a preparation method of Xiaoer Feire Kechuan Granules. Background technique [0002] Xiaoer Feire Kechuan Granule is a compound preparation of eleven traditional Chinese medicines. It has the functions of clearing heat and detoxifying, clearing the lung and relieving cough, resolving phlegm and relieving asthma. It is mainly used for colds, bronchitis, asthmatic bronchitis, and bronchial pneumonia. Witnesses. In order to improve the sweetness of the mouthfeel, make it easier for children to accept, and increase the compliance of children in clinical use, the process of adding excipients is usually used to make sugar-containing specifications. Usually, sucrose is selected as an excipient, which can not only be used as a filler, but also as a sweetener, so it is widely used in oral preparations. However, sucrose is easy to absorb moisture and become damp,...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P11/00A61P11/06A61P11/10A61P11/14A61K9/16A61K47/26A61K47/20A61K33/06
CPCA61K33/06A61K36/195A61K36/315A61K36/8968A61K36/78A61K36/484A61K36/355A61K36/736A61K36/8964A61K36/17A61K36/634A61K36/539A61K9/1623A61K9/1617A61P11/00A61P11/06A61P11/14A61P11/10A61K2236/331A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 刘景萍刘全国陈克领林海银吴育强
Owner HAINAN HULUWA PHARMA GRP CO LTD
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