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Biogel for treating refractory ulcer and preparation method thereof

A biogel technology for refractory ulcers, applied in biochemical equipment and methods, medical preparations containing active ingredients, medical raw materials derived from mammals, etc. good healing effect

Active Publication Date: 2021-09-17
BO AI HOSPITAL OF ZHONGSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, there was a method of using autologous peripheral blood to prepare platelet-enriched plasma for the treatment of diabetic ulcers, but the therapeutic effect is mediocre, especially for elderly patients with poor physical fitness or anemia, and multiple blood draws will inevitably aggravate the condition

Method used

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  • Biogel for treating refractory ulcer and preparation method thereof
  • Biogel for treating refractory ulcer and preparation method thereof
  • Biogel for treating refractory ulcer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0035] This embodiment of a novel bio-gel preparation, their preparation method is simple, drawn aseptically, convenient, readily prepared. Proceed as follows:

[0036] 1, to prepare the necessary materials:

[0037] (1) Application to Blood Center a unit of platelets (200 mL), divided into 4 pouch, sealed shock to save backup;

[0038] (2) simultaneously apply a freshly thawed cryoprecipitate unit (25 ~ 30mL), standby;

[0039] (3) Preparation of the mass fraction of 10% calcium chloride solution 10mL, standby;

[0040] (4) prepare a lyophilized powder thrombin 2-3 bottles (2000U), the standby.

[0041] 2, Biogel prepared:

[0042] (1) Preparation of a Bio-Gel pouch day taken platelets, extracted using a sterile syringe into a first corner of the first sterile tray;

[0043] (2) Preparation of Bio-Gel day remove cryoprecipitate, extraction using a sterile syringe into a second sterile second curved plate;

[0044] (3) the lyophilized powder thrombin was dissolved to 10% solution ...

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PUM

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Abstract

The invention relates to a biogel for treating refractory ulcer and a preparation method thereof, and the biogel is prepared by mixing materials comprising mechanically collected platelets or artificially separated and concentrated platelets, cryoprecipitates, a 10% calcium chloride solution and thrombin freeze-dried powder,the dosage ratio of mechanically collected platelets or artificially separated and concentrated platelets to the cryoprecipitate to the 10% calcium chloride solution to the thrombin freeze-dried powder is (50mL-67 mL): (20mL-30 mL): (3mL-5 mL): (4000-6000 U). The biogel can effectively treat refractory ulcers, and the raw materials are easy to obtain, safe, reliable and easy to prepare.

Description

Technical field [0001] The present invention relates to a Bio-Gel technical field, and particularly relates to a Bio-Gel preparation for the treatment of refractory ulcers. Background technique [0002] Chronic skin ulcers (chronic skin ulcer, CSU), also known as refractory ulcer, is a common refractory disease, including vascular ulcers, pressure ulcers, radiation ulcers and infection of the ulcers. CSU has brought great suffering to the patient from a physically and mentally. Although people try a variety of methods used to treat chronic ulcers, such as: sterilization, improve microcirculation, accelerate the necrotic tissue and promote granulation tissue growth, repair ulcers, etc., but little clinical effect. [0003] The reason most intractable ulcer healing is inadequate amount of tissue and blood circulation disorders. There are conventionally prepared using autologous peripheral blood platelet-enriched plasma method for treating diabetic ulcers, but its therapeutic effect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/48A61K9/06A61P17/02A61K35/19A61K35/16A61K33/14
CPCA61K38/4833A61K35/19A61K35/16A61K33/14A61K9/06A61K9/0014A61P17/02C12Y304/21005A61K2300/00Y02A50/30
Inventor 鞠文东丁高明葛峰黄峻王丽郑岷敏欧清黄晓丹
Owner BO AI HOSPITAL OF ZHONGSHAN
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