Hypouricemic medicine and preparation method thereof

Abstract

The invention relates to a hypouricemic medicine and a preparation method thereof. The hypouricemic medicine comprises a soybean fermentation extract, a plantaginis semen extract and an eurycoma longifolia extract. The preparation method of the hypouricemic medicine comprises the following specific steps: step one, crushing soybeans, carrying out fermentation, carrying out extraction, separation and purification right after the completion of the fermentation, performing concentration on the liquid after the extraction, separation and purification, and performing freeze-drying on the residual slurry under reduced pressure to obtain a soybean fermentation extract; step two, crushing plantaginis semen, adding deionized water, performing ultrasonic extraction, separation and purification, performing vacuum concentration on the residual liquid, and carrying out spray drying to obtain the plantaginis semen extract; step three, crushing eurycoma longifolia, adding deionized water, performing ultrasonic extraction, separation and purification, performing vacuum concentration on the residual liquid, and carrying out spray drying to obtain the eurycoma longifolia extract; step four, mixing the plantaginis semen extract with the eurycoma longifolia extract according to a ratio of 1: 10 to obtain a plantaginis semen and eurycoma longifolia mixed extract; and step five, mixing the soybean fermentation extract with the plantaginis semen and eurycoma longifolia mixed extract according to a mass ratio of (1-2): (2-3).

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a uric acid-lowering medicine and a preparation method thereof. Background technique [0002] Uric acid is the terminal metabolite of human purine compounds. Disorders of purine metabolism lead to hyperuricemia. The prevalence of this disease is affected by many factors, related to heredity, sex, age, lifestyle, eating habits, drug treatment and economic development. Hyperuricemia is the basis of gout. Gout is a recurrent attack caused by increased purine biosynthesis and metabolism, excessive uric acid production or poor excretion of uric acid, resulting in elevated uric acid in the blood and deposition of urate crystals in the synovium, synovial bursa, cartilage and other tissues Inflammatory diseases. It is a group of heterogeneous diseases caused by the supersaturation of monosodium urate crystals (MSU) or uric acid in extracellular fluid, resulting in the deposition of ...

AI Technical Summary

Problems solved by technology

Among them, febuxostat and allopurinol are xanthine oxidase inhibitors, which reduce the production of uric acid in the body to achieve the purpose of lowering uric acid. The side effect is that there is obvious damage to the cardiovascular and cerebrovascular, leading to the occurrence of cardiovascular and cerebrovascular diseases; The principle of action of Longan is to reduce the concentration of blood uric acid by dilating the glomerulus to excrete uric acid, which has large side effects and can easily lead to the occurrence of uremia; probesulfone and colchicine are used in the acute stage of gout, and the side effects are particularly obvious