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Chitosan solution resistant to irradiation degradation and irradiation sterilization method thereof

A chitosan solution, radiation sterilization technology, applied in the direction of radiation, disinfection, etc., can solve the problems of chitosan molecular weight drop, viscosity drop, reduce the radiation degradation of liquid chitosan, etc., to improve stability, The effect of reducing degradation and improving the effect of film formation and antibacterial effect

Pending Publication Date: 2021-09-24
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the sterilization of medical materials adopts steam sterilization and radiation sterilization, which will cause the molecular weight of chitosan to decrease.
After chitosan is sterilized by cobalt-60, the β-(1→4) ether bond on the chitosan main chain is broken, resulting in a significant decrease in its viscosity, which affects the film-forming properties of chitosan solution and antibacterial properties
[0003] Chinese patent CN1563106A discloses a method for preparing low-molecular-weight or water-soluble sugars by radiation. Chinese patent ZL201710883206.7 discloses a method for preparing low-molecular-weight chitosan. The prior art only discloses how to prepare low-molecular-weight chitosan by radiation. However, there is currently no technology to reduce the degradation of liquid chitosan by irradiation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of chitosan solution resistant to radiation degradation:

[0045] Add 5g of chitosan with a viscosity-average molecular weight of 110KDa and a degree of deacetylation ≥ 90% to 500g of purified water, add 2.5g of glacial acetic acid, stir to fully dissolve the chitosan, continue stirring and add 40g of glycerin, 30g of n-butanol, and 6g of propylene glycol , dilute to 1L, stir for 10 minutes until the solution is evenly mixed;

[0046] Sterilization of chitosan solutions resistant to radiation degradation:

[0047] 1) Fill the mixed solution into chitosan solution;

[0048] 2) The chitosan solution was irradiated with 60Co γ-rays at room temperature (Guangzhou Huada Biotechnology Co., Ltd.), the dose was 3-6kGy, and the viscosity-average molecular weight of chitosan after irradiation was 80.3 KDa.

Embodiment 2

[0050] Preparation of chitosan solution resistant to radiation degradation:

[0051] Add 10g of chitosan with a viscosity-average molecular weight of 231KDa and a degree of deacetylation ≥ 90% to 500g of purified water, add 5g of glacial acetic acid, and stir to fully dissolve the chitosan. Continue stirring to add 50g of glycerin, 35g of n-butanol, and 8g of propylene glycol. Dilute to 1L, stir for 10 minutes until the solution is evenly mixed;

[0052] Sterilization of chitosan solutions resistant to radiation degradation:

[0053] 1) Fill the mixed solution into chitosan solution;

[0054] 2) The chitosan solution is irradiated and sterilized by 60Co γ-ray irradiation (Guangzhou Huada Biotechnology Co., Ltd.), with a dose of 8-16kGy. After irradiation, the viscosity-average molecular weight of chitosan is 194KDa.

Embodiment 3

[0056] Preparation of chitosan solution resistant to radiation degradation:

[0057] Add 20g of chitosan with a viscosity-average molecular weight of 423KDa and a degree of deacetylation ≥ 90% to 500g of purified water, add 10g of glacial acetic acid, stir to fully dissolve the chitosan, continue stirring and add 60g of glycerin, 40g of n-butanol, and 10g of propylene glycol. Dilute to 1L, stir for 10 minutes until the solution is evenly mixed;

[0058] Sterilization of chitosan solutions resistant to radiation degradation:

[0059] 1) Fill the mixed solution into chitosan solution;

[0060] 2) The chitosan solution was irradiated and sterilized by 60Co γ-ray irradiation (Guangzhou Huada Biotechnology Co., Ltd.), with a dose of 14-28kGy. After irradiation, the viscosity-average molecular weight of chitosan was 308.79KDa.

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Abstract

The invention relates to chitosan, in particular to a chitosan solution resistant to irradiation degradation and an irradiation sterilization method thereof, and belongs to the technical field of biological material processing. The invention discloses a chitosan solution resistant to irradiation degradation, and the solution is characterized in that the solution comprises the following components in percentage by mass: 0.5%-2% of chitosan, 0.25%-1% of glacial acetic acid, 4%-6% of glycerol, 3%-4% of n-butyl alcohol, 0.6%-1% of propylene glycol, and the balance of water. The glycerol, the n-butyl alcohol and the propylene glycol are added into the chitosan solution, so the degradation of chitosan in the irradiation process of the chitosan solution can be reduced, the stability of the chitosan solution is improved, and the film-forming and bacterium-blocking effects of the chitosan solution are improved.

Description

technical field [0001] The invention relates to a chitosan solution resistant to radiation degradation and a radiation sterilization method thereof, belonging to the technical field of biological material processing. Background technique [0002] Chitosan is a deacetylated chitin product widely found in shrimp, crab and insects. As a natural polymer material, chitosan is widely used in the field of medical materials, and can be used to manufacture chitosan-chitosan membranes and chitosan scaffolds. Chitosan can also be dissolved in acid solution to make chitosan antibacterial film-forming spray. At present, the sterilization of medical materials adopts hot and humid steam sterilization and radiation sterilization, which will cause the molecular weight of chitosan to decrease. After chitosan is sterilized by cobalt-60, the β-(1→4) ether bond on the chitosan main chain is broken, resulting in a significant drop in its viscosity, which affects the film-forming properties of...

Claims

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Application Information

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IPC IPC(8): C08J3/07C08L5/08C08K5/05C08K5/053A61L2/08
CPCC08J3/07A61L2/087C08J2305/08C08K5/05C08K5/053
Inventor 单玲星张俊辉赵澎车七石刘少辉李新霞
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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