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An experimental preparation device and method for frustum-shaped porous pegda microparticles

A technology for preparing a device and microparticles, which is applied in the field of experimental preparation devices for porous PEGDA microparticles, can solve problems such as limiting the development and application of microparticles, and achieve the effect of precise and controllable shape.

Active Publication Date: 2022-04-29
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of phase separation technology to regulate the structure of microparticles does not require complex microfluidic devices, and the structure can be pre-designed by material compatibility, which is precise and easy to operate. Therefore, it is an ideal technology for regulating the structure of microparticles. However, the liquid phase Separation technology is mainly used for the preparation of spherical microparticles, which limits the further development and application of microparticles
Therefore, there is no relatively simple, continuous, and controllable method to prepare non-spherical microparticles with three-dimensional structural characteristics.

Method used

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  • An experimental preparation device and method for frustum-shaped porous pegda microparticles
  • An experimental preparation device and method for frustum-shaped porous pegda microparticles
  • An experimental preparation device and method for frustum-shaped porous pegda microparticles

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Embodiment 1

[0031] refer to figure 1 , an example of the present invention based on the phase separation technology to prepare the experimental device of conical porous PEGDA microparticles, comprising: comprising a base plate 1, a dispensing needle 2, a capillary glass tube 3, an ultraviolet lamp 4 and a collection dish 5; the dispensing needle 2 is fixed on the base plate 1, the bottom plate 1 hangs directly above the collection dish 5; the collection dish 5 is used to contain the oil phase; the upper port of the capillary glass tube 3 communicates with the cavity of the dispensing needle 2, and the lower port of the capillary glass tube 3 The port is in contact with the air-oil phase interface of the collecting vessel 5; the ultraviolet lamp head 4 is placed towards the lower port of the capillary glass tube 3, and the two intersect at a set angle.

[0032] Further, the device for preparing truncated conical porous PEGDA microparticles based on phase separation technology also includes...

Embodiment 2

[0038] Such as figure 2 As shown, the present embodiment also provides a method for preparing truncated conical porous PEGDA microparticles based on phase separation technology, comprising the steps of:

[0039] 1. Preparation of eutectic liquid: at room temperature, mix 0.02ml hydroxyl-2-methylpropiophenone, 1ml PEGDA, and 3ml glycerin, add 1.5ml absolute ethanol dropwise to the resulting mixed solution, and vortex for 5 minutes to obtain eutectic liquid .

[0040] 2. Preparation of the oil phase: Measure 10ml of liquid paraffin and 0.2ml of Span80, mix and vortex for 5 minutes to obtain the oil phase.

[0041] 3. The preparation of frustum-shaped porous PEGDA microparticles is carried out using the device described in Example 1, specifically:

[0042](1) Inject the eutectic liquid prepared in this embodiment into the dispensing needle through a syringe, and when the eutectic liquid drips into the oil phase from the capillary glass tube and is suspended at the air-oil phas...

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Abstract

The invention discloses an experimental preparation device and method for frustum-shaped porous PEGDA microparticles. The UV-curable material polyethylene glycol diacrylate (PEGDA) dissolved in a photoinitiator and high-viscosity glycerin are passed through a co-solvent. After dissolving, it will be dropped into the oily liquid in which the surfactant is dissolved, and suspended at the air-oil interface. Due to the change of the solubility of the eutectic liquid and the interfacial tension of the oil relative to the eutectic liquid, a snowman-shaped droplet will be formed. And on the top of the air-oil interface, that is, the top of the snowman-shaped droplets, there are densely arranged small glycerin droplets, and the droplets undergo a cross-linking polymerization reaction under ultraviolet light, and the frustum-shaped porous PEGDA microparticles are obtained after cleaning and drying. The frustum-shaped porous PEGDA microparticles prepared based on liquid-phase separation technology and using the tension of the air-oil phase interface have the characteristics of obvious three-dimensional shape characteristics, precise and adjustable shape, and simple and easy operation.

Description

technical field [0001] The invention relates to the field of experimental preparation of porous microparticles, in particular to an experimental preparation device and method for frustum-shaped porous PEGDA microparticles. Background technique [0002] From cells in the human body to suspended particles in smog, microparticles can be seen everywhere in people's daily lives. When the particle is reduced from the macroscopic size to the microscopic size, its specific surface area will be greatly increased, which also makes it have many special functions. Microparticles with complex structures, such as core-shell structure, porous structure, bifacial structure, and multilayer structure, have important applications in cosmetics, drug delivery, oil recovery, and cell encapsulation. [0003] At present, methods for preparing spherical microparticles in the laboratory include stirring emulsification, spray drying, vibration dispersion, etc. However, the microparticles prepared by ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/14B01J13/02B01J2/02B01J2/00
CPCB01J13/14B01J13/02B01J2/02B01J2/00
Inventor 满佳华泽升李建勇刘广旭李剑峰
Owner SHANDONG UNIV
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