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A preparation method of Luo Han Guo extract rich in mogroside v

The invention relates to a technique for extracts of Luo Han Guo and Luo Han Guo, which is applied in chemical instruments and methods, glycoside steroids, steroids, etc., and can solve problems such as unfavorable retention of Mogroside, accelerated decomposition of Mogroside V, low content of Mogroside V, and the like, Achieve the effect of improving the effective utilization rate and saving manpower and material resources

Active Publication Date: 2022-03-22
广州泽力医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods all have a certain degree of thermal effect, which is not conducive to the retention of mogroside in Luo Han Guo, and accelerates the decomposition of mogroside V, making the content of mogroside V in Luo Han Guo extract lower.

Method used

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  • A preparation method of Luo Han Guo extract rich in mogroside v
  • A preparation method of Luo Han Guo extract rich in mogroside v
  • A preparation method of Luo Han Guo extract rich in mogroside v

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Effect test

Embodiment 1

[0028] Take the raw material of Luo Han Guo and clean it, then carry out vacuum freeze-drying treatment after cleaning, and then crush the Luo Han Guo dry powder with a particle size of 100 meshes, add 8 times the purified water to the dried Luo Han Guo powder, stir and mix, and use high-efficiency high-pressure differential low-temperature continuous extraction equipment Low-temperature instant extraction, extraction pressure is 25MPa, temperature is 26°C, extraction rate is 7L / min, and the number of extractions is 1 time; the extract is collected and centrifuged at a speed of 6000r / min, centrifuged residue is mixed with 5 times of water, collected Centrifuge the centrifuged liquid at a speed of 7000r / min, and combine the centrifuged liquid; use an ultrafiltration membrane with a molecular weight cut-off of 100,000 Da to perform ultrafiltration separation on the centrifuged liquid. The temperature of the ultrafiltration separation is 30°C and the pressure is 0.35Mpa. ; Concent...

Embodiment 2

[0030] Take the raw material of Luo Han Guo and clean it, then carry out vacuum freeze-drying treatment, and then crush the Luo Han Guo dry powder to a particle size of 80 mesh, add 10 times the purified water to the dried Luo Han Guo powder, stir and mix, and use high-efficiency high-pressure differential low-temperature continuous extraction equipment Instant extraction at low temperature, the extraction pressure is 25MPa, the temperature is 25°C, the extraction rate is 8L / min, and the extraction frequency is 1 time; the extract is collected and centrifuged at a speed of 7000r / min, the centrifuged residue is mixed with 5 times of water, and collected Centrifuge the centrifuged liquid at a speed of 8000r / min, and combine the centrifuged liquid; use an ultrafiltration membrane with a molecular weight cut-off of 80,000 Da for ultrafiltration and separation. The temperature of the ultrafiltration separation is 30°C and the pressure is 0.35Mpa. ; Concentrate the filtrate in vacuum...

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Abstract

The invention provides a preparation method of Luo Han Guo extract, comprising the following steps: (1) raw material pretreatment: the Luo Han Guo is vacuum freeze-dried after being selected and cleaned, and then the Luo Han Guo is crushed to a particle size of 80-120 mesh Luo Han Guo dry powder (2) Extraction: After adding water and mixing the dried Luo Han Guo powder obtained in step (1), transfer to high-efficiency high-pressure differential low-temperature continuous extraction equipment and extract 1-3 times under the condition of 20-30°C to obtain Luo Han Guo extract; ( 3) Separation and purification: centrifuge and ultrafiltrate the Luo Han Guo extract obtained in step (2) to obtain an ultrafiltrate; (4) concentrate in vacuum; obtain the Luo Han Guo extract. The whole process temperature of the preparation method of the present invention is controlled within 30°C, the main active ingredient mogroside V in Luo Han Guo is efficiently retained, and its effective utilization rate is improved.

Description

technical field [0001] The invention relates to the technical field of extracting traditional Chinese medicinal materials, in particular to a preparation method of Luo Han Guo extract rich in mogroside V. Background technique [0002] Luo Han Guo is the fruit of Siraitia grosvenorii Swingle, a perennial vine of Cucurbitaceae, which belongs to the unique economic and medicinal plants in China. China has a long history of using plants to treat diseases. Traditional Chinese medicine believes that Luo Han Guo can refresh the mind and promote body fluid, clear away heat and moisten the lungs, dispel fire and relieve cough, smooth bowel and laxative, etc. It is widely used in the treatment of sore throat and cough. It is an ideal natural sweetener with the characteristics of high sweetness and low calorie, so it can be eaten by patients with diabetes and high blood pressure. Luo Han Guo has the reputation of "Oriental God Fruit" and "Longevity Fruit" in Southeast Asia and Western...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J17/00
CPCC07J17/005
Inventor 刘常青盛周煌宋力飞刘乡乡
Owner 广州泽力医药科技有限公司