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Action mechanism and application of anti-tumor small molecule compound

A technology of small molecular compounds and anti-tumor drugs, applied in the field of medicine, can solve the problems of incomplete elucidation of molecular mechanism and low survival rate, and achieve the effects of inhibiting migration and metastasis, promoting apoptosis, and good anti-tumor activity

Pending Publication Date: 2021-10-22
南京宁宇医疗器材有限公司
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Problems solved by technology

Traditional treatment methods have a certain impact on the long-term prognosis and quality of life of patients, and the 5-year survival rate is low
Furthermore, the various molecular mechanisms involved in the disease have not been fully elucidated

Method used

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  • Action mechanism and application of anti-tumor small molecule compound
  • Action mechanism and application of anti-tumor small molecule compound
  • Action mechanism and application of anti-tumor small molecule compound

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Embodiment Construction

[0027] The present invention will be described in further detail below.

[0028] The antitumor small molecule compound provided by the present invention is N-(4-(naphthalene-2-ylmethyl)phenyl)ethylenesulfonamide, and the molecular formula is C 19 h 18 NOS, molecular structure such as figure 1 shown.

[0029] The anti-tumor effects of the anti-tumor small molecule compounds provided by the present invention will be described in detail below through specific experiments and in conjunction with the accompanying drawings.

[0030] 1. Small molecule compounds down-regulate the expression of TEAD2

[0031] Western blot was used to detect the expression of small molecule compounds on the molecular level of TEAD2 in the tongue squamous cell line Cal-27. Such as figure 2 As shown, the test results showed that small molecular compounds can significantly down-regulate the protein expression level of TEAD2 in Cal-27 cells, and this down-regulation is concentration-dependent. That i...

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Abstract

The invention provides functions and possible molecular mechanisms of an anti-tumor small molecular compound, the compound is N-(4-(naphthalene-2-ylmethyl)phenyl)vinylsulfonamide, the molecular formula being C18H25N3O4, and the molecular structural formula being shown in the specification. The possible molecular mechanism of the small molecule compound is that the protein expression of an important transcription factor TEAD2 molecule in the tongue squamous cell carcinoma is obviously reduced, so that the abnormal growth of tumor cells is inhibited, the apoptosis of the tumor cells is promoted, and the invasion and metastasis capability of the tumor is inhibited. Through molecular targeted therapy, the drug effect is improved, and toxic and side effects caused by broad-spectrum chemotherapeutic drugs are reduced. The compound is simple in structure and easy to synthesize, lays a good foundation for development of novel anti-tumor drugs, especially innovative targeting drugs for tongue squamous cell carcinoma, and provides a wider application prospect for later single-drug treatment and combined treatment.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the action mechanism and application of an anti-tumor small molecular compound. Background technique [0002] Malignant tumor is one of the diseases that seriously endanger human health. Tongue squamous cell carcinoma (Oral tongue squamous cell carcinoma, OTSCC) is one of the most common malignant tumors in the oral and maxillofacial region. Because of its biological characteristics such as high susceptibility to lymph node metastasis and strong invasiveness, it seriously threatens the lives of patients. healthy. Traditional treatment methods have a certain impact on the long-term prognosis and quality of life of patients, and the 5-year survival rate is low. Furthermore, the various molecular mechanisms involved in this disease have not been fully elucidated. Therefore, identification of effective biomarkers is crucial to improve the diagnosis, treatment, and pro...

Claims

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Application Information

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IPC IPC(8): C07C311/11A61P35/00A61P35/04A61K31/18
CPCC07C311/11A61P35/00A61P35/04A61K31/18
Inventor 王双朱彪王一株党瑞杰
Owner 南京宁宇医疗器材有限公司
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