Magnetic COF surface molecular imprinting electrochemical sensor as well as preparation method and application thereof

A surface molecular imprinting and electrochemistry technology, applied in the fields of material electrochemical variables, scientific instruments, material analysis by electromagnetic means, etc., can solve the problems of low detection sensitivity, incomplete reorganization, tight structure, etc., and achieve high specificity detection. Effect

Active Publication Date: 2021-10-29
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, although molecularly imprinted electrochemical sensors have been reported more and more in the field of food safety detection, the detection targets involve pesticide residues, biotoxins, food allergens, and pathogenic microorganisms, etc., but the construction of molecularly imprinted electrochemical sensors The method of synthesizing MIP in the

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  • Magnetic COF surface molecular imprinting electrochemical sensor as well as preparation method and application thereof
  • Magnetic COF surface molecular imprinting electrochemical sensor as well as preparation method and application thereof
  • Magnetic COF surface molecular imprinting electrochemical sensor as well as preparation method and application thereof

Examples

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Example Embodiment

[0032] Example 1

[0033] A preparation method of a magnetic COF surface molecularly imprinted material, comprising the following steps:

[0034] Step 1, using the method of room temperature synthesis to prepare Fe 3 O 4 @COF composites: the Fe 3 O 4 (0.15 g, 0.65 mmol) was suspended in 50 mL of a solution of 1,3,5-triformylbenzene (0.3 mmol) and benzidine (0.45 mmol) in dimethyl sulfoxide, then sonicated for 10 min. After that, acetic acid (2 mL) was slowly added to the mixed solution and reacted at room temperature for 20 min to form a brown precipitate (Fe 3 O 4 @COF), the resulting brown precipitate was collected with a magnet and washed several times with tetrahydrofuran and anhydrous methanol. Finally, the obtained brown precipitate was dried in a vacuum drying oven to obtain Fe 3 O 4 @COF composite;

[0035] Step 2, preparation of magnetic COF surface molecularly imprinted material: add 0.1 mL of functional monomer 3-aminopropyltriethoxysiloxane (APTES) and 20 ...

Example Embodiment

[0036] Example 2

[0037] A preparation method of a magnetic COF surface molecularly imprinted material, comprising the following steps:

[0038] Step 1, using the method of room temperature synthesis to prepare Fe 3 O 4 @COF composites: the Fe 3 O 4 (0.15 g, 0.65 mmol) was suspended in 50 mL of a solution of 1,3,5-triformylbenzene (0.3 mmol) and benzidine (0.45 mmol) in dimethyl sulfoxide, then sonicated for 10 min. After that, acetic acid (2 mL) was slowly added to the mixed solution and reacted at room temperature for 20 min to form a brown precipitate (Fe 3 O 4 @COF), the resulting brown precipitate was collected with a magnet and washed several times with tetrahydrofuran and anhydrous methanol. Finally, the obtained brown precipitate was dried in a vacuum drying oven to obtain Fe 3 O 4 @COF composite;

[0039] Step 2, preparation of magnetic COF surface molecularly imprinted material: 0.5 mL of functional monomer 3-aminopropyltriethoxysiloxane (APTES) and 20 mg o...

Example Embodiment

[0040] Example 3

[0041] A preparation method of a magnetic COF surface molecularly imprinted material, comprising the following steps:

[0042] Step 1, using the method of room temperature synthesis to prepare Fe 3 O 4 @COF composites: the Fe 3 O 4 (0.15 g, 0.65 mmol) was suspended in 50 mL of a solution of 1,3,5-triformylbenzene (0.3 mmol) and benzidine (0.45 mmol) in dimethyl sulfoxide, then sonicated for 10 min. After that, acetic acid (2 mL) was slowly added to the mixed solution and reacted at room temperature for 20 min to form a brown precipitate (Fe 3 O 4 @COF), the resulting brown precipitate was collected with a magnet and washed several times with tetrahydrofuran and anhydrous methanol. Finally, the obtained brown precipitate was dried in a vacuum drying oven to obtain Fe 3 O 4 @COF composite;

[0043] Step 2, preparation of magnetic COF surface molecularly imprinted material: 0.7 mL of functional monomer 3-aminopropyltriethoxysiloxane (APTES) and 20 mg o...

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Abstract

The invention relates to the technical field of electrochemical sensing analysis and detection and food detection and sensing, and relates to a magnetic COF surface molecular imprinting electrochemical sensor as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, preparing a Fe3O4 and COF composite material Fe3O4@COF by using a room temperature synthesis method, and then synthesizing the Fe3O4@COF@MIP composite material by using a surface imprinting method; and modifying the surface of a screen-printed electrode with the Fe3O4@COF@MIP in a dispensing manner, and thus, successfully preparing the electrochemical sensor based on a magnetic COF surface molecularly imprinted material. The sensor prepared by the invention can be used for high-selectivity and high-sensitivity detection of tetracycline.

Description

technical field [0001] The invention relates to the technical fields of electrochemical sensing analysis and detection, food detection and sensing, and relates to a magnetic COF surface molecular imprinted electrochemical sensor, a preparation method and an application. Background technique [0002] Tetracycline (tetracycline, TC) is a typical antibiotic, which not only has bactericidal and antibacterial effects, but also can promote the growth of animals, so it is often used in animal breeding. Unreasonable use of tetracycline will lead to its residues in animal foods, and people's long-term consumption of foods containing tetracycline residues will cause harm to human health. At present, there have been a large number of reports on the analysis and detection methods of tetracycline residues in food, but the instrument analysis method based on chromatographic technology uses expensive instruments, complicated operation, and the method requires complicated sample pretreatmen...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N27/48
CPCG01N27/3275G01N27/48
Inventor 杨钰昆史卓王小敏白宝清张锦华范三红
Owner SHANXI UNIV
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