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Magnetic COF surface molecular imprinting electrochemical sensor as well as preparation method and application thereof

A surface molecular imprinting and electrochemistry technology, applied in the fields of material electrochemical variables, scientific instruments, material analysis by electromagnetic means, etc., can solve the problems of low detection sensitivity, incomplete reorganization, tight structure, etc., and achieve high specificity detection. Effect

Active Publication Date: 2021-10-29
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, although molecularly imprinted electrochemical sensors have been reported more and more in the field of food safety detection, the detection targets involve pesticide residues, biotoxins, food allergens, and pathogenic microorganisms, etc., but the construction of molecularly imprinted electrochemical sensors The method of synthesizing MIP in the process has the disadvantages of low capacity, insufficient template and incomplete recombination, too compact structure, and lack of effective recognition sites, which will affect the recognition and adsorption of the target on the sensor interface.
In addition, the poor conductivity of molecularly imprinted electrochemical sensors leads to low detection sensitivity

Method used

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  • Magnetic COF surface molecular imprinting electrochemical sensor as well as preparation method and application thereof
  • Magnetic COF surface molecular imprinting electrochemical sensor as well as preparation method and application thereof
  • Magnetic COF surface molecular imprinting electrochemical sensor as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] A method for preparing a magnetic COF surface molecularly imprinted material, comprising the steps of:

[0034] Step 1, adopt the synthetic method at room temperature, prepare Fe 3 o 4 @COF Composites: Fe 3 o 4 (0.15 g, 0.65 mmol) was suspended in 50 mL of dimethyl sulfoxide solution containing 1,3,5-triformylbenzene (0.3 mmol) and benzidine (0.45 mmol), and then sonicated for 10 min. Afterwards, acetic acid (2mL) was slowly added to the mixed solution, and reacted at room temperature for 20min to form a brown precipitate (Fe 3 o 4 @COF), the resulting brown precipitate was collected with a magnet and washed several times with THF and anhydrous methanol. Finally, the obtained brown precipitate was dried in a vacuum oven to obtain Fe 3 o 4 @COF Composites;

[0035] Step 2, preparation of molecularly imprinted materials on the magnetic COF surface: Take 0.1 mL of functional monomer 3-aminopropyltriethoxysiloxane (APTES) and 20 mg of template molecule tetracycline ...

Embodiment 2

[0037] A method for preparing a magnetic COF surface molecularly imprinted material, comprising the steps of:

[0038] Step 1, adopt the synthetic method at room temperature, prepare Fe 3 o 4 @COF Composites: Fe 3 o 4 (0.15 g, 0.65 mmol) was suspended in 50 mL of dimethyl sulfoxide solution containing 1,3,5-triformylbenzene (0.3 mmol) and benzidine (0.45 mmol), and then sonicated for 10 min. Afterwards, acetic acid (2mL) was slowly added to the mixed solution, and reacted at room temperature for 20min to form a brown precipitate (Fe 3 o 4 @COF), the resulting brown precipitate was collected with a magnet and washed several times with THF and anhydrous methanol. Finally, the obtained brown precipitate was dried in a vacuum oven to obtain Fe 3 o 4 @COF Composites;

[0039] Step 2, preparation of molecularly imprinted materials on the magnetic COF surface: Take 0.5 mL of the functional monomer 3-aminopropyltriethoxysiloxane (APTES) and 20 mg of the template molecule tetra...

Embodiment 3

[0041] A method for preparing a magnetic COF surface molecularly imprinted material, comprising the steps of:

[0042] Step 1, adopt the synthetic method at room temperature, prepare Fe 3 o 4 @COF Composites: Fe 3 o 4 (0.15 g, 0.65 mmol) was suspended in 50 mL of dimethyl sulfoxide solution containing 1,3,5-triformylbenzene (0.3 mmol) and benzidine (0.45 mmol), and then sonicated for 10 min. Afterwards, acetic acid (2mL) was slowly added to the mixed solution, and reacted at room temperature for 20min to form a brown precipitate (Fe 3 o 4 @COF), the resulting brown precipitate was collected with a magnet and washed several times with THF and anhydrous methanol. Finally, the obtained brown precipitate was dried in a vacuum oven to obtain Fe 3 o 4 @COF Composites;

[0043] Step 2, preparation of molecularly imprinted materials on the magnetic COF surface: Take 0.7 mL of the functional monomer 3-aminopropyltriethoxysiloxane (APTES) and 20 mg of the template molecule tetra...

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Abstract

The invention relates to the technical field of electrochemical sensing analysis and detection and food detection and sensing, and relates to a magnetic COF surface molecular imprinting electrochemical sensor as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, preparing a Fe3O4 and COF composite material Fe3O4@COF by using a room temperature synthesis method, and then synthesizing the Fe3O4@COF@MIP composite material by using a surface imprinting method; and modifying the surface of a screen-printed electrode with the Fe3O4@COF@MIP in a dispensing manner, and thus, successfully preparing the electrochemical sensor based on a magnetic COF surface molecularly imprinted material. The sensor prepared by the invention can be used for high-selectivity and high-sensitivity detection of tetracycline.

Description

technical field [0001] The invention relates to the technical fields of electrochemical sensing analysis and detection, food detection and sensing, and relates to a magnetic COF surface molecular imprinted electrochemical sensor, a preparation method and an application. Background technique [0002] Tetracycline (tetracycline, TC) is a typical antibiotic, which not only has bactericidal and antibacterial effects, but also can promote the growth of animals, so it is often used in animal breeding. Unreasonable use of tetracycline will lead to its residues in animal foods, and people's long-term consumption of foods containing tetracycline residues will cause harm to human health. At present, there have been a large number of reports on the analysis and detection methods of tetracycline residues in food, but the instrument analysis method based on chromatographic technology uses expensive instruments, complicated operation, and the method requires complicated sample pretreatmen...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N27/48
CPCG01N27/3275G01N27/48
Inventor 杨钰昆史卓王小敏白宝清张锦华范三红
Owner SHANXI UNIV
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