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Cuprous sulfide nano antibacterial agent, preparation method and application thereof

A nano-antibacterial agent, cuprous sulfide technology, applied in the field of cuprous sulfide nano-antibacterial agent and its preparation, can solve the problems of large particle size, high equipment requirements, narrow particle size distribution, etc., and achieves low cost, broad application prospects, Simple effect of experimental equipment

Pending Publication Date: 2021-11-02
ANHUI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The solid-phase method is to change the particles with larger particle size into smaller particles through ball milling through physical methods. Although the solid-phase method can mass-produce products, the obtained particle size is relatively large, and impurities are inevitably introduced. , the particle size distribution of the prepared nanoparticles is uneven; compared with the solid phase method, the product prepared by the gas phase method has higher purity and narrow particle size distribution, but the requirements for equipment are higher

Method used

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  • Cuprous sulfide nano antibacterial agent, preparation method and application thereof
  • Cuprous sulfide nano antibacterial agent, preparation method and application thereof
  • Cuprous sulfide nano antibacterial agent, preparation method and application thereof

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preparation example Construction

[0035] The invention discloses a preparation method of a cuprous sulfide nano antibacterial agent, the preparation method comprising: performing a first contact reaction on copper nanoparticles and an etchant to obtain the cuprous sulfide nano antibacterial agent; wherein, the The average particle size of the copper nanoparticles is 2-6nm, the valence state of the copper element in the copper nanoparticles contains positive divalent, and the etchant is selected from at least one of reduced glutathione, cysteine ​​and serine. A sort of.

[0036] In the present invention, the consumption of described copper nanoparticles and etchant is not specifically limited, but in order to make this cuprous sulfide nano antibacterial agent have more excellent antibacterial property, preferably, described copper nanoparticles and etching The weight ratio of the agent is 1:3-1:12.

[0037] In the present invention, the conditions of the first contact reaction are not specifically limited, but...

Embodiment 1

[0051] Step 1: the ascorbic acid AA that takes 0.023mmol (4mg) is dissolved in the water of 2mL to obtain ascorbic acid solution, in the ascorbic acid solution, add the NaOH solution of 1mol / L until the pH of ascorbic acid solution is close to 14 (making the pH of the mixture 1 finally obtained is 7), then slowly drip the ascorbic acid solution into 3mL of CuCl 2 Solution (concentration is 4.2mg / mL, containing 0.093mmol CuCl 2 ), stirred at 25° C. for 30 min to prepare mixture 1.

[0052] Step 2: Add 0.7mL of the prepared mixture 1 (washed by centrifugation, dried and weighed on an electronic balance to obtain 10.2mg of copper nanoparticles) into 4mL of reduced GSH aqueous solution (50mmol / L, containing 61.4mg of reduced GSH), and stirred at 25°C, as the stirring proceeded, a white precipitate slowly appeared, and was stirred for 1h. After the reaction finishes, it is centrifuged and washed with 8000rpm for 10min, then washed 3 times with ethanol (75% by volume), and the pre...

Embodiment 2

[0054] Carry out according to the method for embodiment 1, only difference is, in step 1, ascorbic acid solution is adjusted pH by the NaOH solution of 1mol / L until the pH of ascorbic acid solution is close to 14 (so that the pH of final mixture 1 is 8).

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Abstract

The invention discloses a cuprous sulfide nano antibacterial agent, a preparation method and application thereof. The preparation method comprises the following steps: carrying out first contact reaction on copper nanoparticles and an etching agent to prepare the cuprous sulfide nano antibacterial agent, wherein the average particle size of the copper nanoparticles is 2-6 nm, the valence state of the copper element in the copper nanoparticles contains positive bivalence, and the etching agent is selected from at least one of reduced glutathione, cysteine and serine. According to the invention, the cuprous sulfide nano antibacterial agent has excellent antibacterial performance and dye degradation performance, and the preparation method has the advantages of being simple in process and easy and convenient to operate, so that the antibacterial agent can be widely applied to the antibacterial field and the dye degradation field.

Description

technical field [0001] The invention relates to copper nanoparticles, in particular to a cuprous sulfide nano antibacterial agent and its preparation method and application. Background technique [0002] Bacterial infection has become a major threat to human health, even leading to the death of more and more developing countries and underdeveloped regions, so the demand for antibacterial materials is even more urgent. In recent years, due to the widespread use of antibiotics, the problem of bacterial infection has indeed been suppressed to a certain extent, but at the same time, another new problem has emerged, that is, many drug-resistant superbugs have emerged. The so-called superbugs are more harmful. For example, the number of deaths caused by "super bacteria" in the United States can reach 18,000 cases per year, exceeding the 16,000 people who died of AIDS in the United States in 2005; in the past two years, 313 people in France have had VRE urinary tract or digestive ...

Claims

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Application Information

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IPC IPC(8): C01G3/12A01N59/20B01J27/04B01J35/02C02F1/72C02F1/50A01P1/00C02F101/38
CPCC01G3/12A01N59/20B01J27/04C02F1/505C02F1/725C02F1/722C02F2101/40C01P2002/01C01P2004/64C01P2004/04C01P2002/82C01P2002/85B01J35/40
Inventor 何月珍尹曼悦孙健
Owner ANHUI NORMAL UNIV
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