Medicine balloon catheter and preparation method thereof

A balloon catheter and drug technology, applied in balloon catheters, catheters, etc., to reduce the loss rate, avoid blocking capillaries, and reduce losses

Inactive Publication Date: 2021-11-09
成都百瑞恒通医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing marketed drug expansion balloon catheter uses the contrast agent iopromide as a carrier and paclitaxel as a drug coating on the balloon catheter to treat coronary restenosis, which can improve the drug transfer rate, but the contrast agent In the diagnosis process, there is a certain incidence of complications, and because iopromide is a large hydrophilic molecule, it cannot effectively carry lipophilic paclitaxel through the membrane lipid bilayer into the cell

Method used

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  • Medicine balloon catheter and preparation method thereof
  • Medicine balloon catheter and preparation method thereof
  • Medicine balloon catheter and preparation method thereof

Examples

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preparation example Construction

[0027] A preparation method of a drug balloon catheter, comprising the following steps:

[0028] S1. Activating the balloon: using cold active plasma to activate and pretreat the surface of the balloon 2 to form uniform attachment sites 4 on the surface of the balloon 2;

[0029] S2. Balloon surface treatment: the outer surface of the balloon 2 has a plurality of downwardly recessed storage cavities 3, preferably, the storage cavities 3 are located between two adjacent attachment sites 4, specifically, semi-compliant The balloon 2 is evenly laser engraved on the surface of the balloon 2, and a plurality of openings are uniformly carved on the surface of the balloon 2, and each opening is tilted and rotated to the inner layer of the balloon 2 with the opening as the center of the engraving, so that it is in the balloon 2 An inwardly recessed storage cavity 3 is formed on the upper surface, and the size of the opening of the storage cavity 3 away from the catheter 1 is smaller t...

Embodiment 1

[0046] A preparation method of a drug balloon catheter, comprising the following steps:

[0047] S1. Install the parts that need to prepare the drug balloon catheter on the ultrasonic spraying machine, so that the balloon is inflated and rotated;

[0048] S2. Use a plasma cleaner to generate cold active plasma to activate and pretreat the surface of the balloon. The power is 10w, the activation distance is 5mm, and the activation time is 60s;

[0049] S3. Balloon surface treatment: select a semi-compliant balloon, uniformly laser engrave on the surface of the balloon, and evenly engrave multiple openings on the surface of the balloon, and rotate and engrave the inner layer of the balloon at each opening with the opening as the center , so that an inwardly recessed storage cavity is formed on the balloon, and the size of the opening of the storage cavity on the side away from the catheter is smaller than the aperture inside the storage cavity;

[0050] S4. Dissolve the active ...

Embodiment 2

[0054] A preparation method of a drug balloon catheter, comprising the following steps:

[0055] S1. Install the parts that need to prepare the drug balloon catheter on the ultrasonic spraying machine, so that the balloon is inflated and rotated;

[0056] S2. Use a plasma cleaner to generate cold active plasma to activate and pretreat the surface of the balloon. The power is 30w, the activation distance is 40mm, and the activation time is 30s;

[0057] S3. Balloon surface treatment: select a semi-compliant balloon, uniformly laser engrave on the surface of the balloon, and evenly engrave multiple openings on the surface of the balloon, and rotate and engrave the inner layer of the balloon at each opening with the opening as the center , so that an inwardly recessed storage cavity is formed on the balloon, and the size of the opening of the storage cavity on the side away from the catheter is smaller than the aperture inside the storage cavity;

[0058] S4. Dissolve the probuc...

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Abstract

The invention provides a preparation method of a medicine balloon catheter. The preparation method comprises the following steps that S1, a balloon is activated, specifically, activation pretreatment is carried out on the surface of the balloon by using cold active plasma; S2, first medicine coating is carried out, specifically, a medicine solution is crushed into fine particles, and part of the medicine solution is uniformly sprayed on the surface of the balloon; S3, pre-freezing is carried out; S4, drying and crystallizing are carried out, specifically, the medicine solution on the surface of the balloon is dried to crystallize the outer surface of the medicine; and S5, the medicine is repeatedly coated, specifically, the steps S2 to S4 are continuously repeated on the rest medicine solution until the spraying medicine reaches the required dosage, and the medicine balloon catheter is obtained. According to the preparation method of the medicine balloon catheter, a simple, convenient and rapid coating medicine carrying process with controllable medicine amount can be provided, so that the medicine is firmly adhered to the surface of the balloon, the loss of the medicine in the conveying process is reduced, the bioavailability of the medicine after reaching a targeted part can be improved, and the long-term medicine effect of the medicine is improved.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a drug balloon catheter and a preparation method thereof. Background technique [0002] Intracranial atherosclerotic stenosis is one of the important causes of ischemic stroke. The invention of the stent provides a better solution for atherosclerosis and intravascular stenosis, greatly improving the treatment efficiency, but at the same time Intravascular and in-stent restenosis have occurred, and the therapeutic effect on small blood vessels, bifurcated blood vessels and in situ lesions is not ideal. At present, the methods used for restenosis include: simple balloon re-expansion, directional atherectomy, rotational atherectomy, intravascular radiotherapy and repeated stent implantation, etc. Existing bare balloon and drug stents exist Certain limitations, the restenosis rate of the bare balloon is high, and the therapeutic effect of the drug stent on small vessels and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/10
CPCA61M25/1029A61M2025/105A61M2025/1031
Inventor 何俊淅徐兰馨
Owner 成都百瑞恒通医疗科技有限公司
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