Medicine balloon catheter and preparation method thereof

Abstract

The invention provides a preparation method of a medicine balloon catheter. The preparation method comprises the following steps that S1, a balloon is activated, specifically, activation pretreatment is carried out on the surface of the balloon by using cold active plasma; S2, first medicine coating is carried out, specifically, a medicine solution is crushed into fine particles, and part of the medicine solution is uniformly sprayed on the surface of the balloon; S3, pre-freezing is carried out; S4, drying and crystallizing are carried out, specifically, the medicine solution on the surface of the balloon is dried to crystallize the outer surface of the medicine; and S5, the medicine is repeatedly coated, specifically, the steps S2 to S4 are continuously repeated on the rest medicine solution until the spraying medicine reaches the required dosage, and the medicine balloon catheter is obtained. According to the preparation method of the medicine balloon catheter, a simple, convenient and rapid coating medicine carrying process with controllable medicine amount can be provided, so that the medicine is firmly adhered to the surface of the balloon, the loss of the medicine in the conveying process is reduced, the bioavailability of the medicine after reaching a targeted part can be improved, and the long-term medicine effect of the medicine is improved.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a drug balloon catheter and a preparation method thereof. Background technique [0002] Intracranial atherosclerotic stenosis is one of the important causes of ischemic stroke. The invention of the stent provides a better solution for atherosclerosis and intravascular stenosis, greatly improving the treatment efficiency, but at the same time Intravascular and in-stent restenosis have occurred, and the therapeutic effect on small blood vessels, bifurcated blood vessels and in situ lesions is not ideal. At present, the methods used for restenosis include: simple balloon re-expansion, directional atherectomy, rotational atherectomy, intravascular radiotherapy and repeated stent implantation, etc. Existing bare balloon and drug stents exist Certain limitations, the restenosis rate of the bare balloon is high, and the therapeutic effect of the drug stent on small vessels and ...

AI Technical Summary

Problems solved by technology

The existing marketed drug expansion balloon catheter uses the contrast agent iopromide as a carrier and paclitaxel as a drug coating on the balloon catheter to treat coronary restenosis, which can improve the drug transfer rate, but the contrast agent In the diagnosis process, there is a certain incidence of complications, and because iopromide is a large hydrophilic molecule, it cannot effectively carry lipophilic paclitaxel through the membrane lipid bilayer into the cell

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