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LncRNA-063 and application thereof

A preparation and energy metabolism technology, applied in the field of LncRNA-063 and its application, can solve problems such as developmental defects and various diseases, and achieve the effects of promoting energy metabolism, improving insulin sensitivity, and lowering blood sugar

Inactive Publication Date: 2021-11-23
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, recent studies have found that many lncRNAs have very important physiological functions, and their abnormal levels can lead to developmental defects and the occurrence and development of various diseases

Method used

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  • LncRNA-063 and application thereof
  • LncRNA-063 and application thereof
  • LncRNA-063 and application thereof

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Embodiment Construction

[0020] An application of LncRNA-063 in the preparation of preparations for promoting body energy metabolism and resisting obesity.

[0021] The preparation for promoting body energy metabolism and resisting obesity is a preparation for promoting the differentiation of beige fat cells into brown fat cells.

[0022] The preparation for promoting body energy metabolism and resisting obesity is a preparation for lowering blood sugar and improving insulin sensitivity.

[0023] LncRNA-063 sequence such as figure 1 as shown (( http: / / feb2014.archive.ensembl.org / Mus_ muscles / Transcript / Exons? db=core; g=ENSMUSG00000075391; r=2:35340361- 35341316;t=ENSMUST00000179063 )). To study the inducing effect of LncRNA-063 on the browning of beige fat, we constructed an adenovirus expressing LncRNA-063 (Ad-LncRNA-063), and transduced preadipocytes with the constructed adenovirus expressing LncRNA, and then Brown adipocyte orientation was induced, oil red staining and qRT-PCR results sho...

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Abstract

The invention discloses an application of LncRNA-063 in preparation of a preparation for promoting body energy metabolism and resisting obesity. The effect is exact, and the LncRNA-063 effectively promotes the energy metabolism of an organism by promoting the beige adipocytes to differentiate into the brown adipocytes, so that obesity is resisted; and the effects of reducing blood sugar and improving insulin sensitivity are achieved.

Description

technical field [0001] The present invention relates to a LncRNA-063 and its use. Background technique [0002] Obesity is a physiological state of energy metabolism disorder in the body, which is characterized by a large amount of excess energy accumulated in the body in the form of fat. Obesity is a serious threat to human health, it can induce a variety of metabolic diseases, such as fatty liver, type 2 diabetes, cardiovascular disease, certain types of cancer, etc. There are two main types of adipose tissue in the body, namely white adipose tissue and brown adipose tissue. In terms of energy metabolism, white adipocytes contain a large amount of triglycerides, so white adipose tissue is mainly used as an organ for storing body energy; in contrast, brown adipocytes contain a large number of mitochondria and highly express the uncoupling protein UCP1, which can be passed through Uncoupling converts stored energy into heat and emits it, so BAT is considered an energy-cons...

Claims

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Application Information

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IPC IPC(8): A61K31/7088A61P3/04A61P3/10
CPCA61K31/7088A61P3/04A61P3/10
Inventor 孙诚
Owner NANTONG UNIVERSITY
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