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Folium artemisiae argyi extract and preparation method and application thereof

A wormwood leaf extract and the technology of the extract are applied in the field of plant-derived antibacterial preparations, which can solve the problems of complex formula and low recurrence rate, and achieve the effects of expanding the scope of application, simple preparation and wide sources.

Active Publication Date: 2021-11-30
湖北嘉绘生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition has a good therapeutic effect on various dermatophytes such as tinea pedis, athlete's foot, and onychomycosis, and has a low recurrence rate; however, there is still the problem that the formula is complicated and many auxiliary materials need to be added

Method used

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  • Folium artemisiae argyi extract and preparation method and application thereof
  • Folium artemisiae argyi extract and preparation method and application thereof
  • Folium artemisiae argyi extract and preparation method and application thereof

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preparation example Construction

[0036] Another typical embodiment of the present invention provides a method for preparing the above-mentioned refined extract of Folium Artemisiae Argyi, comprising the following steps:

[0037] (1) The macroporous adsorption resin on the above-mentioned Folium Artemisiae Argyi extract is washed with water, 10% (v / v) ethanol, and 20% (v / v) ethanol successively to remove polysaccharides, proteins and phenolic acids; Pore ​​adsorption resin can be selected from D101, AB-8, ADS-4, ADS-8, SPD-100, LSA-20, XAD-5, preferably D101;

[0038] (2) sequentially use 40% to 95% ethanol aqueous solution for elution; preferably, sequentially use 40%, 60%, and 95% ethanol aqueous solution for elution, and wash until nearly colorless;

[0039] (3) Collect eluents of various concentrations, remove the eluting solvent, and obtain the refined Artemisia argyi leaf extract after freeze-drying; preferably, the eluting solvent is removed by rotary steaming under reduced pressure at 40-50°C.

[0040...

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Abstract

The invention discloses a folium artemisiae argyi extract and a preparation method and application thereof to dermatophyte antibacterial agents, and belongs to the field of technical application of plant source antibacterial agents. The antibacterial agents are folium artemisiae argyi extracts prepared by taking traditional Chinese medicinal materials of folium artemisiae argyi as raw materials through ultrasonic extraction (5-75% ethanol) or ethanol reflux extraction, and have an efficient inhibition effect on dermatophytes such as trichophyton rubrum, trichophyton mentagrophytes and microsporum gypseum. After the folium artemisiae argyi extracts are separated and purified through macroporous adsorption resin, 40-95% ethanol separation components have different degrees of inhibition activity on the dermatophytes, wherein the 95% ethanol separation components are most significant. Meanwhile, the main chemical components in the 95% ethanol separation components are eupatilin, physcion, vitexin, brown cyanidin and the like. The folium artemisiae argyi extract can efficiently inhibit the dermatophytes, has the advantages of safety, high efficiency and low toxic and side effects, and provides a new drug source for prevention and treatment of dermatophyte diseases such as tinea of feet and hands.

Description

technical field [0001] The invention belongs to the technical application field of plant-derived antibacterial preparations, and in particular relates to a natural antibacterial agent based on mugwort leaves extract and its preparation method and application. Background technique [0002] Dermatophytosis is a skin infection caused by glial-friendly dermatophytes infecting the skin, fur, and deck of humans or animals. The head, hands, and feet can all be infected. Dermatophytosis is widely prevalent in the world, more common in tropical and subtropical regions, and the incidence rate in my country is also quite high. Symptoms of different degrees due to the difference of different patients, bothering a large number of people. At present, a large number of studies have shown that the pathogenic bacteria of dermatophytosis such as tinea corporis and tinea manus and pedis are roughly the same, mainly including Trichophyton, Epidermophyton and Microsporum, etc., the most common o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61P17/00A61P31/10
CPCA61K36/282A61P17/00A61P31/10
Inventor 刘大会陈乐杜鸿志赵璐李金鑫朱芸芸
Owner 湖北嘉绘生物科技有限公司
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