Bio-based antibacterial dental restoration material with high biocompatibility and preparation method thereof

A technology of biocompatibility and restorative materials, applied in the field of highly biocompatible bio-based antibacterial dental restoration materials and its preparation, can solve the problem of low antibacterial period and service life, reduction or disappearance of resin antibacterial ability, and influence on resin mechanics Performance and other issues, achieve significant antibacterial effect, strong inhibition, and prolong service life

Active Publication Date: 2021-12-17
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the antibacterial performance of the antibacterial resin in the above-mentioned patents is positively correlated with the release performance of the antibacterial substance. Therefore, as time goes on, the release of the antibacterial substance will decrease, and the antibacterial ability of the resin will decrease or disappear; It will affect the mechanical properties of the resin, so the use of composite resin dental restoration materials with added metal silver / copper nanoparticles will have the problem of low antibacterial period and service life

Method used

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  • Bio-based antibacterial dental restoration material with high biocompatibility and preparation method thereof
  • Bio-based antibacterial dental restoration material with high biocompatibility and preparation method thereof
  • Bio-based antibacterial dental restoration material with high biocompatibility and preparation method thereof

Examples

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preparation example Construction

[0033] A preparation method of a bio-based antibacterial dental restoration material with high biocompatibility, comprising the following steps:

[0034] S1. Stir and mix 5',5-diallyl-2,2'-biphenyldiol and pentaerythritol tetramercaptoacetate at 110°C at a stirring speed of 200-400r / min to dissolve them completely. The mass-number ratio of 5',5-diallyl-2,2'-diphenol and pentaerythritol tetramercaptoacetate is 38-45:55-62;

[0035] S2. Add 2-isopropylthioxanthone (ITX) to the mixed solution obtained in step S1, stir until completely dissolved, the ratio of mass and number of 2-isopropylthioxanthone (ITX) to the mixed solution of S1 1~3:100;

[0036] S3, adding tetraethylenesilane into the mixed solution of S2, the mass-number ratio of the mixture of tetraethylenesilane and S2 is 20-40:100;

[0037] S4. Carrying out vacuum defoaming treatment at 110° C. in the mixed solution obtained in step S3 to obtain a white or yellow viscous bio-based antibacterial dental restorative mate...

Embodiment 1

[0043] Example 1 of the present invention prepares a bio-based antibacterial material applied to dental restorative materials, comprising the following steps:

[0044] S1. Stir and mix 3.8g of 5',5-diallyl-2,2'-diphenol and 6.2g of pentaerythritol tetramercaptoacetate at 110°C at a stirring speed of 200r / min to make them completely dissolve;

[0045] S2. Add 100 mg of 2-isopropylthioxanthone (ITX) into the mixed solution obtained in step S1, and stir until completely dissolved;

[0046] S3, adding 2g of tetraethylenesilane into the mixed solution in step S2 and stirring evenly;

[0047] S4. The mixed solution obtained in step S3 is subjected to vacuum defoaming treatment at 110° C. to obtain a white or yellow viscous bio-based antibacterial dental restorative material with high biocompatibility.

[0048] The dental restorative material obtained in Example 1 was coated on a PTFE plate, and irradiated with 365nm ultraviolet light for 10 minutes to cure the dental material, and...

Embodiment 2

[0053] Example 2 of the present invention prepares a bio-based antibacterial material applied to dental restorative materials, comprising the following steps:

[0054] S1. Stir and mix 4.5g 5',5-diallyl-2,2'-diphenol and 5.5g pentaerythritol tetramercaptoacetate at 110°C at a stirring speed of 200r / min to make them completely dissolve;

[0055] S2. Add 300mg of 2-isopropylthioxanthone (ITX) into the mixed solution obtained in step S1, and stir until completely dissolved;

[0056] S3, adding 4g of tetraethylenesilane into the mixed solution of S2 and stirring evenly;

[0057] S4. The mixed solution obtained in step S3 is subjected to vacuum defoaming treatment at 110° C. to obtain a white or yellow viscous bio-based antibacterial dental restorative material with high biocompatibility.

[0058] The dental restorative material obtained in Example 2 was coated on a PTFE plate, and irradiated with ultraviolet light with a wavelength of 365nm for 10 minutes to cure the dental mate...

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Abstract

The invention provides a bio-based antibacterial dental restoration material with high biocompatibility and a preparation method thereof. The bio-based antibacterial dental restoration material is prepared by using 5', 5-diallyl-2, 2'-biphenol and pentaerythritol tetramercaptoacetate as reactants, tetravinylsilane as a filler and 2-isopropyl thioxanthone as a catalyst through addition polymerization, wherein tetravinylsilane is used for replacing a traditional silicon dioxide filler, addition polymerization is carried out on tetravinylsilane and pentaerythritol tetramercaptoacetate, so that organic thermosetting resin and the filler are combined in a chemical bond mode, the hardness and abrasion resistance of the material can be improved, and the material is good in mechanical property and stable in quality. The dental restoration material prepared by using 5', 5-diallyl-2, 2'-biphenol as a raw material has a long-acting antibacterial effect, and the service life of the dental restoration material is prolonged; and moreover, the material has high biocompatibility, and the risk that other chemically synthesized light-cured dental resin materials remain in a human body for a long time to generate toxicity is solved.

Description

technical field [0001] The invention relates to the technical field of materials, in particular to a bio-based antibacterial dental restoration material with high biocompatibility and a preparation method thereof. Background technique [0002] Light-curing resin dental restoration materials have become the most commonly used dental restoration materials in the oral medical industry because of their low price, simple molding, and good individual matching. However, light-curing resin dental restoration materials have the problem of easy adhesion of bacteria, which can cause dental caries. Therefore, the development of antibacterial composite resin dental restoration materials is an important way to improve light-curing resin dental restoration materials. [0003] At present, the industry mainly adds metal silver / copper nanoparticles to composite resin dental restoration materials to endow the resin with antibacterial function. Patent No. CN104887535B discloses a preparation ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/80A61K6/831A61K6/69
CPCA61K6/80A61K6/831A61K6/69
Inventor 杨红军王宗垒王玉丽周永恒庄燕周应山刘欣徐卫林
Owner WUHAN TEXTILE UNIV
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