Preparation method of dual-emission quantum dot and application of dual-emission quantum dot in biological imaging

A quantum dot and double-emission technology, which is applied in the fields of chemistry and nanomaterials science, can solve the problems that ordinary metal quantum dots cannot be imaged, and achieve the effects of controllable synthesis method, low biological toxicity and high quantum yield

Pending Publication Date: 2021-12-31
CHONGQING MEDICAL UNIVERSITY
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

Another problem is that ordinary metallic quantum dots cannot be used for in vivo imaging

Method used

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  • Preparation method of dual-emission quantum dot and application of dual-emission quantum dot in biological imaging
  • Preparation method of dual-emission quantum dot and application of dual-emission quantum dot in biological imaging
  • Preparation method of dual-emission quantum dot and application of dual-emission quantum dot in biological imaging

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Embodiment 1

[0035] Zn(Ac) 2 , Ag(NO) 3 、In(Ac) 3 , Se, ZnS(S and Zn(Ac) 2 ) according to the molar ratio of 5:2:5:14:1. First Zn(Ac) 2 , Ag(NO) 3 、In(Ac) 3 , Se were dispersed in 4 mL 1-octadecene (ODE), 500 μL dodecyl mercaptan (DT), 50 μL oleic acid (OA), 500 μL oleylamine (OLA) and 200 μL dodecyl mercaptan (DT) in a mixed solvent; at 150°C, under the condition of nitrogen protection, magnetic stirring (500rpm), reacted for 30min, to obtain the nuclear solution of double-emission quantum dots; then under the same reaction conditions, pre-ultrasonic solution was dissolved in 100μL OLA and 400μL The ZnS solution of ODE is continuously and slowly dropped into the core solution of quantum dots, reacted for 1.5h, and then forms the shell layer of quantum dots on the surface of the core; cools to room temperature, obtains the crude product dispersion of double emission quantum dots, and purifies the crude product Dispersion, ZAISe / ZnS is obtained.

Embodiment 2

[0037] Zn(Ac) 2 , Ag(NO) 3 、In(Ac) 3 , Se, ZnS(S and Zn(Ac) 2 ) according to the molar ratio of 5:2:5:14:1. First Zn(Ac) 2 , Ag(NO) 3 、In(Ac) 3 , Se were dispersed in 4 mL 1-octadecene (ODE), 500 μL dodecyl mercaptan (DT), 50 μL oleic acid (OA), 500 μL oleylamine (OLA) and 200 μL dodecyl mercaptan (DT) in a mixed solvent; at 170°C, under the condition of nitrogen protection, magnetic stirring (500rpm), reaction for 30min, to obtain the nuclear solution of double-emission quantum dots; then under the same reaction conditions, pre-ultrasonic solution was dissolved in 100μL OLA and 400μL The ZnS solution of ODE is continuously and slowly dropped into the core solution of quantum dots, reacted for 1.5h, and then forms the shell layer of quantum dots on the surface of the core; cools to room temperature, obtains the crude product dispersion of double emission quantum dots, and purifies the crude product Dispersion, ZAISe / ZnS is obtained.

Embodiment 3

[0039] Zn(Ac) 2 , Ag(NO) 3 、In(Ac) 3 , Se, ZnS(S and Zn(Ac) 2 ) according to the molar ratio of 5:2:5:14:0.5 feeding. First Zn(Ac) 2 , Ag(NO) 3 、In(Ac) 3 , Se were dispersed in 4 mL 1-octadecene (ODE), 500 μL dodecyl mercaptan (DT), 50 μL oleic acid (OA), 500 μL oleylamine (OLA) and 200 μL dodecyl mercaptan (DT) in a mixed solvent; at 150°C, under the condition of nitrogen protection, magnetic stirring (500rpm), reacted for 30min, to obtain the nuclear solution of double-emission quantum dots; then under the same reaction conditions, pre-ultrasonic solution was dissolved in 100μL OLA and 400μL The ZnS solution of ODE is continuously and slowly dropped into the core solution of quantum dots, reacted for 1.5h, and then forms the shell layer of quantum dots on the surface of the core; cools to room temperature, obtains the crude product dispersion of double emission quantum dots, and purifies the crude product Dispersion, ZAISe / ZnS is obtained.

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Abstract

The invention discloses a preparation method of a dual-emission quantum dot and an application of the dual-emission quantum dot in biological imaging, wherein the dual-emission quantum dot is prepared by taking zinc acetate (Zn(Ac)2), silver nitrate (Ag(NO)3), indium acetate (In(Ac)3) and selenium powder (Se) as main raw materials as a core of the quantum dot, taking zinc acetate (Zn(Ac)2) and sulfur powder as a precursor solution as a shell layer of the quantum dot, and preparing the reaction product at a certain temperature under the protection of nitrogen. The prepared dual-emission quantum dot is high in quantum yield and good in stability, has two emission peaks of visible light region emission and near-infrared region emission, and can be used for in-vivo and in-vitro biological imaging.

Description

technical field [0001] The invention belongs to the field of chemistry and nanometer material science, and relates to a preparation method of double emission quantum dots and the application of biological imaging thereof. Background technique [0002] Quantum dots (Quantum dots, QDs) are quasi-zero-dimensional nanomaterials, also known as nanocrystals, generally composed of II-VI, III-V, IV-VI elements, or two or more The composition of the elements, the size is generally 1nm-100nm, with special properties such as quantum confinement effect, surface effect, macroscopic quantum tunneling effect and size effect. Nanomaterials, quantum dots have been widely used in biological imaging and labeling, ion detection, solar cells and other fields. [0003] Due to the unique advantages of quantum dots in biological related fields, the preparation raw materials and synthesis methods of quantum dots have been extensively explored, and some progress has been made in the synthesis of raw...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/88C09K11/02G01N21/64B82Y20/00B82Y30/00A61K49/00
CPCC09K11/883C09K11/02G01N21/6428A61K49/0019B82Y20/00B82Y30/00
Inventor 邓涛余清华于超
Owner CHONGQING MEDICAL UNIVERSITY
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