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Pyridine base synthesis method and device

A synthesis method and technology of a synthesis device, which are applied in separation methods, chemical instruments and methods, organic compound/hydride/coordination complex catalysts, etc., can solve the problem of short catalyst life, difficult removal, and low pyridine base process yield and other problems, to achieve the effect of uniform catalyst distribution, reduction of coking phenomenon, and reduction of self-polymerization reaction.

Active Publication Date: 2022-01-07
ANHUI COSTAR BIOCHEM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the synthesis process of pyridine base by aldehyde ammonia method mainly adopts metal-loaded ZSM-5 molecular sieve, which has a short life and relatively low yield of pyridine base
Chinese patent CN200710150336.6 discloses a new type of catalyst used in the synthesis of pyridine bases and its preparation and use methods. High silica molecular sieves are used as the matrix to catalyze the preparation of pyridine bases through dealumination and desiliconization. The yield of pyridine bases can be up to 65% or more; however, the yield of pyridine bases synthesized by such catalysts is relatively low, and deacidification and desiliconization are required, and the steps are cumbersome
[0005] At present, the yield of pyridine base synthesis by aldehyde-ammonia method is low, and formaldehyde and acetaldehyde are coked and blocked at the reactor inlet during the reaction process, and the temperature is too high and Difficult to remove heat, while the life of the catalyst is short and the product yield is low

Method used

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  • Pyridine base synthesis method and device
  • Pyridine base synthesis method and device

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Effect test

Embodiment 1

[0034] Fix the ZSM-5 molecular sieve loaded with 2% ionic liquid on the distributor of reactor 1, and then activate the temperature at 300°C for 2h. After the activation, the temperature of reactor 1 is raised to 350°C, and the pressure is 1MPa. Formaldehyde: acetaldehyde: The ratio of NH3 is 1.1:1:3 and it is continuously fed into the reactor 1. The reaction gas passes through the regenerator 2 and the gas-solid separator 3 and then enters the evaporator 4. The regeneration temperature of the regenerator 2 is 450°C, and then enters the heat exchanger 5 After condensation, the condensed liquid enters the centrifugal extractor 6 for continuous extraction, and the extract is passed through the evaporation condenser 7 and the rectification tower 8 to obtain pyridine base, and the yield of pyridine base is 88.2%.

Embodiment 2

[0036] Fix the ZSM-5 molecular sieve loaded with 3% ionic liquid on the distributor of reactor 1, and then activate the temperature at 350°C for 2h. : The NH3 ratio is 2:1:3 and is continuously fed into the reactor 1. The reaction gas enters the evaporator 4 after passing through the regenerator 2 and the gas-solid separator 3. The regeneration temperature of the regenerator 2 is 400 ° C, and then enters the heat exchanger 5 condensation, the condensed liquid enters the centrifugal extractor 6 for continuous extraction, and the extract is passed through the evaporation condenser 7 and the rectification tower 8 to obtain pyridine base, and the yield of pyridine base is 90.5%.

Embodiment 3

[0038] Fix the ZSM-5 molecular sieve loaded with 5% ionic liquid on the distributor of reactor 1, and then activate the temperature at 350°C for 2h. After the activation, the temperature of reactor 1 is raised to 400°C and the pressure is 0.3MPa. : The ratio of NH3 is 2:1:3.5 and is continuously fed into reactor 1. The reaction gas enters evaporator 4 after passing through regenerator 2 and gas-solid separator 3. The regeneration temperature of regenerator 2 is 500°C, and then enters the heat exchanger 5 condensation, the condensed liquid enters the centrifugal extractor 6 for continuous extraction, and the extract is passed through the evaporation condenser 7 and the rectification tower 8 to obtain pyridine base, and the yield of pyridine base is 90.5%.

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Abstract

The invention discloses a pyridine base synthesis method and device, and the method comprises the following steps: catalyst activation: taking an ionic liquid-loaded ZSM-5 molecular sieve as a catalyst, fixing the catalyst on a distributor of a reactor, introducing nitrogen, conducting activating at 300-350 DEG C for 2-4 hours, gasifying mixed aldehyde, introducing the gasified mixed aldehyde into a bottom catalyst bed layer of the reactor through a bottom sleeve, meanwhile, introducing NH3 for reaction, enabling reaction gas and a catalyst to enter a regenerator through the top of the reactor, regenerating the catalyst in the regenerator after the catalyst passes through a gas-solid separator, and enabling the reaction gas from the reactor to sequentially enter an evaporator and a heat exchanger for cooling, wherein the evaporator generates steam, and the heat exchanger heats raw materials; and feeding a product from the heat exchanger into a centrifugal extractor, an evaporative condenser and a rectifying tower, so as to separate out a pyridine base product. According to the method, on the basis of adopting the ionic liquid loaded zeolite molecular sieve, the pyridine base is synthesized by adopting the reactor of the renewable catalyst, so that the yield of the pyridine base is improved.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a pyridine base synthesis method and device. Background technique [0002] Pyridine and its derivatives are very important chemical intermediates, which are widely used in medicine, pesticide, feed, synthetic rubber and dye industries, and can also be used in the production of surfactants and food additives. Industrially, pyridine is mainly used in the production of sulfonamides, penicillin, vitamin A, cortisone, anthelmintics and local anesthetics, etc. It is also used in stabilizers, softeners, paint solvents, condensing agents for synthetic resins, and for synthetic weed control. Preservatives, preservatives and hydroxypyridine, etc. [0003] At present, the synthesis process of pyridine base by aldehyde ammonia method mainly adopts metal-loaded ZSM-5 molecular sieve, which has a short lifespan and a relatively low yield of pyridine base. Chinese patent CN20071015...

Claims

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Application Information

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IPC IPC(8): B01J8/02B01D3/14B01D11/04B01J31/02C07D213/10
CPCB01J8/02B01D11/048B01D3/14C07D213/10B01J31/0284B01J31/0292Y02P20/584
Inventor 刘敏张强蒋伟李习红袁晓路潘峡刘建吴超
Owner ANHUI COSTAR BIOCHEM CO LTD