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Traditional Chinese medicine composition for treating small intestine mucosa injury caused by non-steroidal anti-inflammatory drugs, and preparation method and preparation thereof

A non-steroidal anti-inflammatory drug, small intestinal mucosa technology, applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc. Lowers the effect of peptic ulcer

Pending Publication Date: 2022-01-11
DONGZHIMEN HOSPITAL OF BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the mechanism of NSAIDs-related small intestinal injury is still unclear, there are only sporadic clinical reports of teprenone, which is traditionally used as a gastric mucosal protective agent, in small intestine-related mucosal injury (Washio E, Esaki M, Maehata Y, et al. Proton pump inhibitors increase incidence of nonsteroidal anti-inflammatory drug-induced small bowl injury: arandomized, placebo-controlled Trial. Clin Gastroenterol Hepatol, 2016, 14(6): 809-815.), large-scale clinical trials and animal trials have not yet found a drug with a positive effect

Method used

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  • Traditional Chinese medicine composition for treating small intestine mucosa injury caused by non-steroidal anti-inflammatory drugs, and preparation method and preparation thereof

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Experimental program
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Effect test

Embodiment 1

[0031] A traditional Chinese medicine composition for treating small intestinal mucosal damage caused by non-steroidal anti-inflammatory drugs, the raw materials include the following components in parts by weight:

[0032] 7 parts of Coptis chinensis, 3 parts of Scutellaria baicalensis, 3 parts of Sophora japonica, 2 parts of arborvitae leaves, 2 parts of Nepeta japonica, 3 parts of Citrus aurantium, 2 parts of Puhuang, 7 parts of Wulingzhi, 3 parts of pomegranate peel.

[0033] The preparation method is as follows:

[0034] (1) Take the raw materials according to the above proportions, add water to decoct, boil on low heat for 1 hour; filter to obtain filtrate 1 and filter residue respectively, and filtrate 1 is bottled for subsequent use;

[0035] (2) Get the medicinal dregs obtained above, add water to decoct, boil on low heat for 1 hour after boiling, filter to obtain filtrate 2, and bottle for subsequent use;

[0036] (3) Filtrate 1 and Filtrate 2 are combined to obtain...

Embodiment 2

[0038] A traditional Chinese medicine composition for treating small intestinal mucosal damage caused by non-steroidal anti-inflammatory drugs, the raw materials include the following components in parts by weight:

[0039] 30 parts of Coptis chinensis, 15 parts of Scutellaria baicalensis, 15 parts of Sophora japonica, 10 parts of arborvitae leaves, 10 parts of Nepeta japonica, 15 parts of Citrus aurantii, 10 parts of Puhuang, 30 parts of Wulingzhi, 15 parts of pomegranate peel.

[0040] The preparation method is as follows:

[0041] (1) Take the raw materials according to the above ratio, add water to decoct, boil on low heat for 1 hour; filter to obtain filtrate 1 and filter residue respectively, and precipitate filtrate 1 to take the supernatant and bottle it for later use;

[0042] (2) Get the medicinal dregs obtained above, add water to decoct, boil on low heat for 1 hour, filter to obtain filtrate 2, precipitate filtrate 2 and get the supernatant and bottle it for subseq...

Embodiment 3

[0045] A traditional Chinese medicine composition for treating small intestinal mucosal damage caused by non-steroidal anti-inflammatory drugs, the raw materials include the following components in parts by weight:

[0046] 14 parts of Coptis chinensis, 6 parts of Scutellaria baicalensis, 6 parts of Sophora japonica, 4 parts of arborvitae leaves, 4 parts of Nepeta japonica, 6 parts of Citrus aurantium, 4 parts of Puhuang, 14 parts of Wulingzhi, 6 parts of pomegranate peel.

[0047] The preparation method is as follows:

[0048] (1) Take the raw materials according to the above ratio, add water to decoct, boil on low heat for 1 hour; filter to obtain filtrate 1 and filter residue respectively, and precipitate filtrate 1 to take the supernatant and bottle it for later use;

[0049] (2) Get the medicinal dregs obtained above, add water to decoct, boil on low heat for 1 hour, filter to obtain filtrate 2, precipitate filtrate 2 and get the supernatant and bottle it for subsequent u...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating small intestine mucosa injury caused by non-steroidal anti-inflammatory drugs, and a preparation method and a preparation thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 7-30 parts of rhizoma coptidis, 3-15 parts of radix scutellariae, 3-15 parts of flos sophorae, 2-10 parts of cacumen biotae, 2-10 parts of herba schizonepetae, 3-15 parts of fructus aurantii, 2-10 parts of pollen typhae, 7-30 parts of trogopterus dung and 3-15 parts of pericarpium granati. Water is added into the raw materials to perform decocting to prepare the traditional Chinese medicine composition. The traditional Chinese medicine composition is reasonable in compatibility, fills up the blank in the field of small traditional Chinese medicine compound treatment of small intestinal mucosal lesion, relieves small intestinal mucosal lesion caused by NSAIDs, reduces the probability of occurrence of adverse events such as peptic ulcer, digestive tract hemorrhage or perforation caused by NSAIDs, effectively improves the life quality of patients under the idea of combination of prevention and treatment, is low in cost, and can be well applied clinically.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating small intestinal mucosal damage caused by non-steroidal anti-inflammatory drugs, a preparation method and a preparation thereof. Background technique [0002] Non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, are more and more used in analgesic anti-inflammation and prevention of cardiovascular and cerebrovascular diseases in rheumatic and joint diseases. Adverse events such as sexual ulcer, gastrointestinal bleeding or perforation have become the main complications of this class of drugs (Shiotani A, Kamada T, Haruma K. Low-dose aspirin-induced gastrointestinal diseases: past, present, and future. J Gastroenterol, 2008, 43(8):581-588.). [0003] With the popularity of capsule endoscopy and double-balloon enteroscopy, researchers found that NSAIDs-induced small intestinal mucosal injury ...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P1/04A61K35/24
CPCA61K36/718A61K36/539A61K36/489A61K36/14A61K36/538A61K36/752A61K36/88A61K35/24A61K36/185A61P1/04A61K2236/331A61K2300/00
Inventor 贾博陈江宁田芝雷刘蓬蓬宁守斌赵乐怡
Owner DONGZHIMEN HOSPITAL OF BEIJING UNIV OF CHINESE MEDICINE
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