Biodegradable stent and preparation method thereof

A biodegradable polymer technology, applied in stents, medical science, surgery, etc., can solve the problems of vascular stenosis, slow degradation of stent residues, adverse side effects, etc., achieve fast degradation speed, shorten the degradation time of residues, Reduce the effect of adverse side effects

Pending Publication Date: 2022-01-18
天翊微创医疗科技(常州)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Existing biodegradable polymer stents are made of polymer materials with a single molecular weight. After this kind of degradable stent is implanted in human blood vessels, it can support the diseased blood vessels in the early undegraded period, achieving the support effect and preventing the diseased After recovery, it will be degraded in the middle and later stages and become stent residues. The stent residues left in the vascular endothelium will cause adverse side effects in the lesion or lead to restenosis of the blood vessels. It will not return to normal until the stent matrix is ​​completely degraded. This kind of stent matrix with a single molecular weight has the same degradation rate in the early and late stages of degradation, and the degradation rate of the stent residue is slow. Usually, we hope that the stent will degrade faster after the stent loses its support performance in the later stage of service, thereby reducing the adverse effects of blood vessels. Probability of side effects or restenosis

Method used

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  • Biodegradable stent and preparation method thereof
  • Biodegradable stent and preparation method thereof
  • Biodegradable stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A degradable stent for lower extremity arteries was prepared, with a size specification of 2.0 mm.

[0034] The preparation method is as follows:

[0035] S1. Dry two kinds of lactic acid pellets with a molecular weight of 700,000 and a molecular weight of 400,000 as raw materials. The drying temperature of the polylactic acid pellets with a molecular weight of 700,000 is 120°C, and the drying time is 4 hours; polylactic acid with a molecular weight of 400,000 The drying temperature of the pellets is 100°C, and the drying time is 4 hours;

[0036] S2. Put the dried 700,000 molecular weight polylactic acid pellets into the first extrusion chamber and the third extrusion chamber of the three-screw extruder, and put the dried 400,000 molecular weight polylactic acid pellets into the three-screw extruder The second extrusion bin of the machine; the extrusion process parameters are: the temperature of the screw zone of the first extrusion bin and the third extrusion bin is ...

Embodiment 2

[0040] A degradable stent for lower extremity arteries was prepared, with a size of 4.0 mm.

[0041] The preparation method is as follows:

[0042] S1. Dry two kinds of lactic acid pellets with a molecular weight of 700,000 and a molecular weight of 400,000 as raw materials. The drying temperature of the polylactic acid pellets with a molecular weight of 700,000 is 120°C, and the drying time is 4 hours; polylactic acid with a molecular weight of 400,000 The drying temperature of the pellets is 100°C, and the drying time is 4 hours;

[0043]S2. Put the dried 700,000 molecular weight polylactic acid pellets into the first extrusion chamber and the third extrusion chamber of the three-screw extruder, and put the dried 400,000 molecular weight polylactic acid pellets into the three-screw extruder The second extrusion bin of the machine; the extrusion process parameters are: the temperature of the screw zone of the first extrusion bin and the third extrusion bin is 218 °C, the tem...

Embodiment 3

[0047] A coronary degradable stent was prepared, with a size specification of 3.0 mm.

[0048] The preparation method is as follows:

[0049] S1. Dry two kinds of lactic acid pellets with a molecular weight of 800,000 and a molecular weight of 300,000 as raw materials. The drying temperature of the polylactic acid pellets with a molecular weight of 800,000 is 123°C, and the drying time is 4 hours; polylactic acid with a molecular weight of 400,000 The drying temperature of the pellets is 95°C, and the drying time is 4 hours;

[0050] S2. Put the dried 800,000 molecular weight polylactic acid pellets into the first extrusion chamber and the third extrusion chamber of the three-screw extruder, and put the dried 300,000 molecular weight polylactic acid pellets into the three-screw extruder The second extrusion bin of the machine; the extrusion process parameters are: the temperature of the screw zone of the first extrusion bin and the third extrusion bin is 220°C, the temperatur...

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PUM

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Abstract

The invention provides a biodegradable stent and a preparation method thereof. The biodegradable stent comprises an inner layer, a middle layer and an outer layer, the inner layer and the outer layer are made of a high molecular weight degradable polymer, and the middle layer is made of a low molecular weight degradable polymer. After the biodegradable stent is implanted into a blood vessel of a human body, the biodegradable stent has good supporting performance when not degraded in the early stage, and after the stent begins to degrade in the later stage, only middle-layer low-molecular-weight polymer fragments of a stent base body are basically left in the endothelium of a blood vessel, so that the degradation speed is higher, and the degradation time of stent residues in the later stage can be effectively shortened. Therefore, the probability of occurrence of adverse side effects or restenosis of the blood vessel is reduced.

Description

technical field [0001] The invention belongs to the technical field of biological scaffolds, in particular to a biodegradable scaffold with a three-layer structure prepared from polymers with different molecular weights and a preparation method thereof. Background technique [0002] Existing biodegradable polymer stents are made of polymer materials with a single molecular weight. After this kind of degradable stent is implanted in human blood vessels, it can support the diseased blood vessels in the early undegraded period, achieving the support effect and preventing the diseased After recovery, it will be degraded in the middle and later stages and become stent residues. The stent residues left in the vascular endothelium will cause adverse side effects in the lesion or lead to restenosis of the blood vessels. It will not return to normal until the stent matrix is ​​completely degraded. This kind of stent matrix with a single molecular weight has the same degradation rate ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/915A61L31/12A61L31/06A61L31/14
CPCA61F2/915A61L31/06A61L31/148C08L67/04
Inventor 杨彦周杨运燕张文
Owner 天翊微创医疗科技(常州)有限公司
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