Traditional Chinese medicine composition for preventing and treating endotoxin-mediated acute lung injury and preparation method thereof

A technology for acute lung injury and composition, applied in the field of traditional Chinese medicine formula, can solve the problems of inability to control disease progression and large side effects of western medicine, and achieve the effect of improving the immune pathological damage process of lung tissue, less toxic and side effects, and good therapeutic effect

Active Publication Date: 2022-01-21
TARIM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the prevention and treatment of ALI is mainly based on western medicine. Although it can alleviate the clinical symptoms, it cannot obviously control the progress of the disease, which has certain limitations. In addition, western medicine also has the disadvantage of relatively large side effects. Therefore, it is still necessary to find other drugs for the prevention and treatment of ALI It is a hot topic that people pay attention to nowadays
Traditional Chinese medicine and natural medicine have always been the source of innovative drug discovery due to their high efficacy and low side effects. Therefore, it is very necessary to propose a Chinese medicine composition that can effectively prevent and treat acute lung injury

Method used

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  • Traditional Chinese medicine composition for preventing and treating endotoxin-mediated acute lung injury and preparation method thereof
  • Traditional Chinese medicine composition for preventing and treating endotoxin-mediated acute lung injury and preparation method thereof
  • Traditional Chinese medicine composition for preventing and treating endotoxin-mediated acute lung injury and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A traditional Chinese medicine composition for preventing and treating endotoxin-mediated acute lung injury. The raw materials include the following components in parts by weight: 4 parts of Ophiopogon japonicus, 3 parts of Shuangpi, 3 parts of Radix Ginseng, 4 parts of fried almonds, and 3 parts of Baibu , 5 parts of Peucedanum, 4 parts of Aster, 4 parts of Pinellia, 5 parts of Qingpi, 4 parts of Campanulaceae, 3 parts of Poria, 3 parts of Fritillaria, 4 parts of Melon, 5 parts of Magnolia officinalis, 3 parts of Scutellaria, and 4 parts of Anemarrhena 5 parts, orange red 5 parts.

[0030] The preparation method is as follows:

[0031] S1. Weigh the specified amount of Ophiopogon japonicus, Shuangpi, Radix Ginseng, Fried Almond, Peppermint, Peucedanum, Aster, Pinellia, Qingpi, Campanulaceae, Poria, Fritillaria, Melon, Magnolia officinalis, Scutellaria, Anemarrhena , orange red, add water with a water temperature of 35°C to 55°C over the surface of the medicine for 2-3...

Embodiment 2

[0036] A traditional Chinese medicine composition for preventing and treating endotoxin-mediated acute lung injury. The raw materials include the following components in parts by weight: 8 parts of Radix Ophiopogon japonicus, 5 parts of Shuangpi, 5 parts of Radix Ginseng, 6 parts of fried almonds, and 5 parts of Baibu , 10 parts of Peucedanum, 8 parts of Aster, 8 parts of Pinellia, 10 parts of Qingpi, 8 parts of Campanulaceae, 6 parts of Poria, 6 parts of Fritillaria, 8 parts of Melon, 10 parts of Magnolia officinalis, 6 parts of Scutellaria, 8 parts of Anemarrhena 10 parts, orange red 10 parts.

[0037] The preparation method is the same as in Example 1.

Embodiment 3

[0039] A traditional Chinese medicine composition for preventing and treating endotoxin-mediated acute lung injury. The raw materials include the following components in parts by weight: 10 parts of Radix Ophiopogon japonicus, 8 parts of Shuangpi, 8 parts of Radix Ginseng, 10 parts of fried almonds, and 8 parts of Baibu , 12 parts of Peucedanum, 10 parts of Aster, 10 parts of Pinellia, 12 parts of Qingpi, 10 parts of Campanulaceae, 8 parts of Poria, 8 parts of Chuan Fritillaria, 10 parts of Melon Vine, 12 parts of Magnolia officinalis, 8 parts of Scutellaria baicalensis, 10 parts of Anemarrhena 12 parts, 12 parts orange.

[0040] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating endotoxin-mediated acute lung injury and a preparation method thereof, and belongs to the field of traditional Chinese medicine formulas. The traditional Chinese medicine composition comprises the following components in parts by weight: 4-15 parts of radix ophiopogonis, 3-15 parts of mulberry bark, 3-15 parts of radix adenophorae, 4-15 parts of fried apricot kernel, 3-15 parts of radix stemonae, 5-15 parts of radix peucedani, 4-15 parts of radix asteris, 4-12 parts of rhizoma pinelliae, 5-15 parts of pericarpium citri reticulatae viride, 4-15 parts of radix platycodonis, 3-12 parts of poria cocos, 3-15 parts of bulbus fritillariae cirrhosae, 4-15 parts of melon vine, 5-15 parts of cortex magnoliae officinalis, 3-12 parts of radix scutellariae, 4-12 parts of rhizoma anemarrhenae and 5-15 parts of exocarpium citri rubrum. The traditional Chinese medicine composition disclosed by the invention can effectively inhibit lung tissue inflammation, inhibit secretion of inflammatory factors IL-1beta, IL-6 and TNF-alpha and relieve lung epithelial cell inflammatory injury, and has a good treatment effect on acute lung injury.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine formulas, in particular to a traditional Chinese medicine composition for preventing and treating endotoxin-mediated acute lung injury and a preparation method thereof. Background technique [0002] Acute lung injury (ALI) / acute respiratory distress syndrome (ARDS) is an inflammatory reaction process secondary to the lungs or the whole body, and is caused by various direct or indirect factors that cause damage to alveolar epithelial cells and capillary cells. Vascular endothelial cell damage, resulting in diffuse pulmonary interstitial and alveolar edema, leading to acute hypoxic respiratory insufficiency; acute lung injury is caused by alveolar damage and forms inflammatory non-cardiogenic pulmonary edema, manifested as alveolar wall thickening , inflammatory cell infiltration, uncontrolled coagulation, hypoxemia, etc. At present, the prevention and treatment of ALI is mainly based on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61P11/00
CPCA61K36/8968A61K36/605A61K36/342A61K36/34A61K36/736A61K36/904A61K36/23A61K36/28A61K36/8888A61K36/752A61K36/346A61K36/076A61K36/8966A61K36/42A61K36/575A61K36/539A61K36/8964A61K9/0095A61P11/00A61K2236/331A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 刘俊峰郭雪峰
Owner TARIM UNIV
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