Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition for relieving oxidative stress injury and protecting nerves, preparation method and application

A technology for protecting nerves and oxidative stress, applied in drug combinations, pharmaceutical formulations, nervous system diseases, etc., can solve the problems of low absorption rate of natural ingredients stigmasterol, low intake of stigmasterol, and limited effect, etc., to relieve the brain Oxidative stress damage, immunity improvement, nerve protection effects

Inactive Publication Date: 2022-01-25
XIAN HEALTHFUL BIOTECH
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the intake of stigmasterol is low, and the absorption rate in the human body is only 4.8%, which can play a limited role, so it has not been widely used
[0004] Aiming at problems such as side effects, dependence, poor palatability, and low absorption rate of the natural ingredient stigmasterol, the inventors of the present invention, on the basis of summarizing the prior art, through a large number of experimental research and analysis Summarize, finished the present invention at last

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition for relieving oxidative stress injury and protecting nerves, preparation method and application
  • Pharmaceutical composition for relieving oxidative stress injury and protecting nerves, preparation method and application
  • Pharmaceutical composition for relieving oxidative stress injury and protecting nerves, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Embodiment 1: the preparation of pharmaceutical composition of the present invention

[0079] The implementation steps of this embodiment are as follows:

[0080] A. Wet granulation

[0081] 60 parts by weight of stigmasterol with a purity of 95.2% by weight, 16 parts by weight of soybean lecithin, 12 parts by weight of cholesterol, 34 parts by weight of yam powder carrier with a particle size of 40 to 80 and 12 parts by weight of hydroxypropyl methylcellulose Add the binder composed of microcrystalline cellulose according to the weight ratio of 1:9 to the HLSG-600 wet granulator sold by China Aviation Manufacturing Technology Research Institute, and stir under the conditions of cutting knife speed 2000rpm and stirring speed 120rpm Mix for 8min to obtain a stigmasterol mixture;

[0082] B. Extrude and roll

[0083] Let the stigmasterol mixture obtained in step A be extruded by the GYJ-500 type extrusion spheronizer sold by Chuangzhi Technology (Jiangsu) Co., Ltd. und...

Embodiment 2

[0086] Embodiment 2: the preparation of pharmaceutical composition of the present invention

[0087] The implementation steps of this embodiment are as follows:

[0088] A. Wet granulation

[0089] 80 parts by weight of stigmasterol with a purity of 96.0% by weight, 23 parts by weight of soybean lecithin, 15 parts by weight of cholesterol, 40 parts by weight of amylose carrier with a particle size of 40 to 80 mesh and 14 parts by weight of hydroxypropyl methylcellulose Add the binder composed of vegan and microcrystalline cellulose according to the weight ratio of 1:6 to the HLSG-100 wet granulator sold by Zhejiang Tomorrow Machinery Co., Ltd., and stir under the condition of cutting knife speed 1800rpm and stirring speed 100rpm Mix for 10min to obtain a stigmasterol mixture;

[0090] B. Extrude and roll

[0091] Let the stigmasterol mixture obtained in step A be extruded through the E-100 extruder+S-700 spheronizer sold by Chongqing Yingge Pharmaceutical Machinery Co., Ltd...

Embodiment 3

[0094] Embodiment 3: the preparation of pharmaceutical composition of the present invention

[0095] The implementation steps of this embodiment are as follows:

[0096] A. Wet granulation

[0097] 20 parts by weight of stigmasterol with a purity of 95.8% by weight, 10 parts by weight of soybean lecithin, 5 parts by weight of cholesterol, 20 parts by weight of a maltodextrin carrier with a particle size of 40 to 80 and 10 parts by weight of hydroxypropyl methylcellulose The binder composed of cellulose and microcrystalline cellulose according to the weight ratio of 1:8 is added to the HLSG-600 wet granulator sold by China Aviation Manufacturing Technology Research Institute, under the conditions of cutting knife speed 1500rpm and stirring speed 150rpm Stir and mix for 5min to obtain a stigmasterol mixture;

[0098] B. Extrude and roll

[0099] Let the stigmasterol mixture obtained in step A be extruded through the E-100 extruder+S-700 spheronizer sold by Chongqing Yingge Ph...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
particle sizeaaaaaaaaaa
purityaaaaaaaaaa
Login to View More

Abstract

The invention relates to a pharmaceutical composition for relieving oxidative stress injury and protecting nerves as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition consists of stigmasterol, soya bean lecithin, cholesterol, a carrier and an adhesive. The pharmaceutical composition disclosed by the invention can be used for early prevention, relieving brain oxidative stress injury without side effects and protecting nerves; low-density lipoprotein concentration is reduced, and heart and cerebral vessels are protected; and the cell growth rate capability is improved, the body health is protected, and the immunity is improved.

Description

【Technical field】 [0001] The invention belongs to the technical field of stigmasterol application. More specifically, the present invention relates to a pharmaceutical composition for relieving oxidative stress damage and protecting nerves, a preparation method of the pharmaceutical composition, and an application of the pharmaceutical composition. 【Background technique】 [0002] With the development of society, the pace of people's life and work is accelerating, and the mental pressure of modern people is also increasing. In the long run, oxidative stress is prone to occur, which is due to the imbalance between excessive reactive oxygen species (ROS) and antioxidant enzymes , resulting from the accumulation of excess ROS in the body. All aerobic cells are damaged by oxidative stress, and the human brain is the most sensitive because of its high lipid content and high oxygen consumption (Halliwell B. Role of free radicals in the neurodegenerative diseases: therapeutic impli...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/685A61K9/16A61K47/36A61K47/38A61K47/46A61P9/00A61P25/00A61K31/575
CPCA61K31/575A61K31/685A61K9/1664A61K9/1652A61P25/00A61P9/00A61K2300/00
Inventor 孟永宏赵云博郭建琦牛永洁杨璐
Owner XIAN HEALTHFUL BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com