Feed additive for preventing intestinal barrier injury of piglets as well as preparation method and application of feed additive

A technology for feed additives and intestinal barriers, applied in applications, animal feeds, animal feeds, etc., can solve problems such as damage to intestinal barriers, piglet diarrhea, etc., and achieve the effects of reducing feed-to-meat ratio, reducing permeability, and protecting damage

Pending Publication Date: 2022-02-08
SHENYANG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the technical problem that piglets are easily damaged by immune stress caused by various reasons, causing diarrhea in piglets, and seriously affecting the development of my country's pig breeding industry,

Method used

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  • Feed additive for preventing intestinal barrier injury of piglets as well as preparation method and application of feed additive
  • Feed additive for preventing intestinal barrier injury of piglets as well as preparation method and application of feed additive
  • Feed additive for preventing intestinal barrier injury of piglets as well as preparation method and application of feed additive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A feed additive for preventing intestinal barrier damage of piglets, comprising 640 parts of active components and 350 parts of carrier matrix in parts by weight.

[0046] Among them, the active component is prepared from the following raw materials in parts by weight: 200 parts of taurine, 80 parts of arginine, 80 parts of glutamine, 80 parts of sodium butyrate, 50 parts of zinc oxide, and 50 parts of vitamin A , 50 parts of vitamin C, 50 parts of folic acid.

[0047] In terms of mass percentage, the carrier matrix is ​​prepared from 50% corncob powder and 50% corn gluten powder.

[0048] The specific preparation method is as follows:

[0049] S1. Weighing raw materials according to the weight ratio of the above-mentioned feed additives;

[0050] S2. Take 100 parts of the carrier matrix, add vitamin A, vitamin C, and folic acid, stir and mix evenly, and prepare mixture A;

[0051] S3. Take the remaining carrier matrix, add taurine, arginine, glutamine, sodium butyra...

Embodiment 2

[0061] A feed additive for preventing intestinal barrier damage of piglets, comprising 510 parts of active components and 200 parts of carrier substrates in parts by weight.

[0062] Among them, the active component is prepared from the following raw materials in parts by weight: 150 parts of taurine, 70 parts of arginine, 70 parts of glutamine, 60 parts of sodium butyrate, 40 parts of zinc oxide, and 40 parts of vitamin A , 40 parts of vitamin C, 40 parts of folic acid.

[0063] In terms of mass percentage, the carrier matrix is ​​prepared from 40% of rice bran, 30% of corncob powder and 30% of bentonite.

[0064] The specific preparation method is as follows:

[0065] S1. Weighing raw materials according to the weight ratio of the above-mentioned feed additives;

[0066] S2. Take 100 parts of the carrier matrix, add vitamin A, vitamin C, and folic acid, stir and mix evenly, and prepare mixture A;

[0067] S3. Take the remaining carrier matrix, add taurine, arginine, gluta...

Embodiment 3

[0076] A feed additive for preventing intestinal barrier damage of piglets, comprising 450 parts of active components and 150 parts of carrier substrates in parts by weight.

[0077] Among them, the active component is prepared from the following raw materials in parts by weight: 150 parts of taurine, 60 parts of arginine, 60 parts of glutamine, 60 parts of sodium butyrate, 30 parts of zinc oxide, and 30 parts of vitamin A , 30 parts of vitamin C, 30 parts of folic acid.

[0078] In terms of mass percentage, the carrier matrix is ​​prepared from 50% corncob powder and 50% corn gluten powder.

[0079] The specific preparation method is as follows:

[0080] S1. Weighing raw materials according to the weight ratio of the above-mentioned feed additives;

[0081] S2. Take 80 parts of the carrier matrix, add vitamin A, vitamin C, and folic acid, stir and mix evenly, and prepare mixture A;

[0082] S3. Take the remaining carrier matrix, add taurine, arginine, glutamine, sodium but...

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Abstract

The invention provides a feed additive for preventing intestinal barrier injury of piglets as well as a preparation method and application of the feed additive. The feed additive consists of an active component and a carrier matrix, the active component is prepared from the following raw materials in parts by weight: 150 to 200 parts of taurine, 60 to 80 parts of arginine, 60 to 80 parts of glutamine, 60 to 80 parts of sodium butyrate, 30 to 50 parts of zinc oxide, 30 to 50 parts of vitamin A, 30 to 50 parts of vitamin C and 30 to 50 parts of folic acid. The feed additive can be added into piglet daily ration to prepare piglet feed. The components of the feed additive have synergistic interaction and mutual promotion, so that the influence of LPS on transcellular resistance of intestinal mucosa epithelial cells of piglets can be remarkably prevented, the expression level of tight junction protein of the intestinal mucosa epithelial cells is improved, the mechanical barrier of the intestinal mucosa epithelial cells of the piglets is protected, the permeability of intestinal mucosa is reduced, meanwhile, the daily gain is improved and the feed conversion ratio is reduced.

Description

technical field [0001] The invention relates to the technical field of feed additives, in particular to a feed additive for preventing intestinal barrier damage of piglets, a preparation method and application thereof. Background technique [0002] The intestinal tract is not only the main place for nutrient absorption, but also an important line of defense to protect the body from pathogenic bacteria, and its normal development is crucial to the health of piglets. The intestinal mechanical barrier is composed of intestinal mucosal epithelial cells and their tight junctions to isolate the body from the external environment. Piglet diarrhea caused by damage to the intestinal barrier of piglets caused by various reasons is one of the most important piglet diseases, and it is also an important cause of piglet death. According to survey statistics, the average incidence of diarrhea caused by various reasons accounts for about 50% in piglets below 25kg, and the resulting mortali...

Claims

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Application Information

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IPC IPC(8): A23K50/60A23K50/30A23K10/37A23K20/142A23K20/147A23K20/174A23K20/20A23K20/28
CPCA23K50/30A23K50/60A23K20/142A23K20/30A23K20/174A23K10/37A23K20/147A23K20/28Y02P60/87
Inventor 林树梅盖叶丹曹中赞胡建民杨建成栾新红刘梅赵冬冬梁巍巍李伟伟韩杰杨群辉姜午旗张茗晰张飞于丽辉
Owner SHENYANG AGRI UNIV
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