Improved isoquercitrin, preparation method and application thereof

An improved technology of isoquercitrin, which is applied in the field of improved isoquercitrin and its preparation, can solve the problems of low bioavailability in vivo, limited therapeutic effect, and difficult clinical treatment, etc., and achieve improved bioavailability in vivo, Improve solubility and improve therapeutic effect

Pending Publication Date: 2022-02-08
NANTONG UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Literature reports show that isoquercitrin has a certain improvement effect on stroke and other cardiovascular and cerebrovascular diseases, but the existing isoquercitrin still has certain deficiencies in the treatment of stroke and other cardiovascular and cerebrovascular diseases, such as: isoquercitrin The disadvantages of quercitrin, such as poor water solubility and low bioavailability in vivo, have limited therapeutic effects and are difficult to apply to clinical treatment

Method used

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  • Improved isoquercitrin, preparation method and application thereof
  • Improved isoquercitrin, preparation method and application thereof
  • Improved isoquercitrin, preparation method and application thereof

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Embodiment Construction

[0021] A clear and complete description will be given below in conjunction with the technical solutions in the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0022] The invention provides a technical proposal: the improved isoquercitrin is isoquercitrin-albumin complex or isoquercitrin liposome.

[0023] The preparation method of isoquercitrin-albumin conjugate, its specific steps are as follows:

[0024] S1: Make BSA a 0.05mol / L stock solution with deionized water, and make isoquercitrin a 0.05mol / L stock solution with DMSO;

[0025] S2: Mix BSA stock solution and isoquercitrin stock solution with deionized water by vortexing to make the final concentration ...

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Abstract

The invention discloses improved isoquercitrin, a preparation method and application thereof. The improved isoquercitrin comprises an isoquercitrin-albumin combination body or an isoquercitrin liposome. The invention further provides a preparation method of the isoquercitrin-albumin combination body and a preparation method of the isoquercitrin lipidosome. The invention further provides application of the improved isoquercitrin. The improved isoquercitrin is applied to drugs for preventing and treating stroke and cardiovascular and cerebrovascular diseases. By changing the dosage form of the isoquercitrin, the solubility of the isoquercitrin is remarkably improved, and the in-vivo bioavailability of the isoquercitrin is improved, so that the treatment effect of the isoquercitrin on stroke and related cardiovascular and cerebrovascular diseases is remarkably improved.

Description

technical field [0001] The invention relates to the technical field of improved isoquercitrin, in particular to an improved isoquercitrin and its preparation method and application. Background technique [0002] Isoquercitrin has biological activities such as anti-oxidation, anti-tumor, lowering blood pressure, lowering blood fat, anti-inflammation, analgesia, anti-virus and anti-depression, etc., and is often used as an auxiliary drug or drug active ingredient. The enzymatically modified isoquercetin (EMIQ) synthesized as a raw material is a new multi-purpose food additive with high-quality antioxidant and coloring properties, and its safety has been certified by the US Food and Drug Administration. Literature reports show that isoquercitrin has a certain improvement effect on stroke and other cardiovascular and cerebrovascular diseases, but the existing isoquercitrin still has certain deficiencies in the treatment of stroke and other cardiovascular and cerebrovascular dise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K47/64A61K9/127A61K47/28A61K47/24A61P9/10A61P9/00A61P25/00
CPCA61K31/7048A61K47/643A61K9/127A61K47/28A61K47/24A61P9/10A61P9/00A61P25/00
Inventor 王彩萍石运伟
Owner NANTONG UNIVERSITY
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