High-stability curcumin sustained-release capsule and preparation method thereof
A slow-release capsule and high-stability technology, which is applied in the field of high-stability curcumin sustained-release capsule and its preparation, can solve the problems of limited stability and bioavailability of curcumin preparations, and achieve improved bioavailability and water dispersion Good performance and good sustained release effect
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Embodiment 1
[0030] Accurately weigh 50 mg of PHA, heat and swell with 8 mL of dichloromethane at 30°C, and finally dissolve. Accurately weigh 2 mg of curcumin raw material and dissolve it with 2 mL of dichloromethane. The two obtained solutions were combined into one, and the mixture was slowly blended into 20 mL of 1% PVA solution while stirring, and then 0.5 mL of Tween-20 was added. Subsequently, the obtained mixed solution was sonicated with an ultrasonic instrument at a power of 400 W for 1 h, and then immediately used a rotary evaporator at 35° C. to remove dichloromethane. The liquid after rotary evaporation was collected, centrifuged at 12000rpm / min for 20min, the precipitate was collected and washed 3 times with distilled water, and then dried with a freeze dryer or vacuum dryer, and the obtained solid powder was stored for later use.
[0031] Take 1mg of the above solid powder, add 2mL of PhaP protein in PBS buffer solution (concentration: 1.2mg / mL), stir and combine at 4°C and...
Embodiment 2
[0033] Accurately weigh 50g of PHA, heat and swell with 8L of dichloromethane at 35°C, and finally dissolve. Accurately weigh 2 g of curcumin raw material and dissolve it with 2L of dichloromethane. The obtained two solutions were combined into one, and the mixed solution was slowly blended into 20L of 1% PVA solution with mass fraction while stirring, and then 0.5L of Tween-20 was added. Subsequently, the obtained mixed solution was sonicated with an ultrasonic instrument at a power of 570 W for 1.5 h, and then immediately used a rotary evaporator at 35° C. to remove dichloromethane. The liquid after rotary evaporation was collected, centrifuged at 12000rpm / min for 20min, the precipitate was collected and washed 3 times with distilled water, and then dried with a freeze dryer or vacuum dryer, and the obtained solid powder was stored for later use.
[0034] Take 1g of the above solid powder, add 2L of PhaP protein buffer solution in PBS (concentration: 1.2mg / mL), stir and com...
Embodiment 3
[0036] Accurately weigh 50 mg of PHA, heat and swell with 8 mL of dichloromethane at 35°C, and finally dissolve. Accurately weigh 2 mg of curcumin raw material and dissolve it with 2 mL of dichloromethane. The two obtained solutions were combined into one, and the mixture was slowly blended into 20 mL of 1% PVA solution while stirring, and then 0.5 mL of Tween-20 was added. Subsequently, the obtained mixed solution was sonicated with an ultrasonic instrument at a power of 350 W for 2 hours, and immediately used a rotary evaporator at 35° C. to remove dichloromethane. The liquid after rotary evaporation was collected, centrifuged at 10000rpm / min for 20min, the precipitate was collected and washed 3 times with distilled water, and then dried with a freeze dryer or a vacuum dryer, and the obtained solid powder was stored for later use.
[0037] Take 1mg of the above solid powder, add 2mL of PhaP protein in PBS buffer solution (concentration: 1.3mg / mL), stir and combine at 4°C an...
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Abstract
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