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Medicinal sucrose pellet core and preparation method thereof

A technology of medicinal sucrose and sucrose cores, which is applied in the direction of pharmaceutical formulations, medical preparations of non-effective ingredients, and pill delivery, and can solve the problems of relatively large influence of adhesive brittleness, low yield of sucrose cores, and pill delivery. Low core yield and other issues, to achieve the effect of low cost, convenient operation, and improved mechanical strength

Pending Publication Date: 2022-03-01
JIANGSU ZHONGBANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problems of low yield, brittle texture and easy breakage of sucrose ball cores in the prior art, and the centrifugal granulation process is adopted to prepare sucrose ball cores. The impact of friability is relatively large, and a medicinal sucrose core and its preparation method are provided to solve the problems of low yield and poor friability of the target core

Method used

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  • Medicinal sucrose pellet core and preparation method thereof
  • Medicinal sucrose pellet core and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A sucrose ball core comprises the following raw materials in parts by weight: 60 parts of sucrose, 40 parts of cornstarch; 62% sucrose syrup obtained by heating and boiling a 40% sucrose solution as a binder.

[0036] The concrete preparation method of sucrose ball core is:

[0037] Step (1), premixing: at normal temperature, sucrose and cornstarch are premixed according to the proportion to obtain mixed powder;

[0038] Step (2), pulverization: at normal temperature, the above-mentioned mixed powder is pulverized twice with a platform pulverizer (the internal screen is 150 mesh) to obtain pulverized sucrose starch;

[0039] Step (3), preparation of adhesive: prepare 40% sucrose solution with sucrose and water, heat to boiling, continue to boil for 4 hours to obtain 62% sucrose syrup;

[0040] Step (4), mother nucleus preparation: the 10kg sucrose starch pulverization that step (2) obtains is dropped into centrifugal granulator, 50kg sucrose starch pulverization joins ...

Embodiment 2

[0047] A sucrose ball core comprises the following raw materials in parts by weight: 70 parts of sucrose, 30 parts of cornstarch; 59% sucrose syrup obtained by heating and boiling 45% sucrose solution as a binder.

[0048] The concrete preparation method of sucrose ball core is:

[0049] Step (1), premixing: at normal temperature, sucrose and cornstarch are premixed according to the proportion to obtain mixed powder;

[0050] Step (2), pulverization: at normal temperature, the above-mentioned mixed powder is pulverized twice with a platform pulverizer (the internal screen is 150 mesh) to obtain pulverized sucrose starch;

[0051] Step (3), preparation of adhesive: prepare 45% sucrose solution with sucrose and water, heat to boiling, and continue to boil for 3 hours to obtain sucrose syrup with a final concentration of 59%;

[0052] Step (4), mother core preparation: the 15kg sucrose starch pulverization that step (2) obtains is dropped into centrifugal granulator, and 45kg su...

Embodiment 3

[0059] A sucrose ball core comprises the following raw materials in parts by weight: 85 parts of sucrose, 15 parts of cornstarch; 56% sucrose syrup obtained by heating and boiling a 50% sucrose solution as a binder.

[0060] The concrete preparation method of sucrose ball core is:

[0061] Step (1), premixing: at normal temperature, sucrose and cornstarch are premixed according to the proportion to obtain mixed powder;

[0062] Step (2), pulverization: at normal temperature, the above-mentioned mixed powder is pulverized twice with a platform pulverizer (the internal screen is 150 mesh) to obtain pulverized sucrose starch;

[0063] Step (3), preparation of adhesive: prepare 50% sucrose solution with sucrose and water, heat to boiling, continue to boil for 2 hours to obtain 56% sucrose syrup;

[0064] Step (4), mother core preparation: the 5kg sucrose starch pulverization that step (2) obtains is put into centrifugal granulator, and 55kg sucrose starch pulverization joins in t...

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Abstract

The invention discloses a medicinal sucrose pellet core which comprises the following raw materials in parts by weight: 60-85 parts of sucrose and 15-35 parts of starch. The preparation method comprises the following steps: by taking cane sugar syrup with the concentration of 55-65% obtained by decocting a cane sugar solution with the concentration of 40-50% as an adhesive, pre-mixing, crushing and sieving the raw materials, spraying the cane sugar syrup by adopting a centrifugal granulation process to carry out mother granulation, and then drying, sieving, amplifying, drying and sieving to prepare the medicinal cane sugar pellet core. According to the invention, no additional adhesive is used, the adhesive is prepared from one of the raw material components, and the formula is simpler; the adhesive is decocted, so that the problems of low yield, low hardness and poor friability in the preparation process of the sucrose pellet core are solved; the method is simple in process, convenient to operate and low in cost.

Description

technical field [0001] The invention relates to a sucrose ball core and a preparation method thereof, in particular to a medicinal sucrose ball core and a preparation method thereof. Background technique [0002] Pellets are spherical or quasi-spherical solid dosage forms with a diameter of 0.5-1.0mm, which can be packed into capsules, compressed into tablets, or made into different types of pellets such as sustained-release, enteric-coated and other dosage forms. Pellets are a multi-unit oral dosage form, usually consisting of dozens to thousands of pellets for a single administration. Compared with other dosage forms, micropills have the characteristics of beautiful appearance, good fluidity, wide drug loading range and stable drug release. [0003] According to the difference in the composition of the ball core, the commercially available ball core can be roughly divided into three types: sucrose, microcrystalline cellulose, and starch. The main component of the sucrose...

Claims

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Application Information

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IPC IPC(8): A61K47/26A61K47/36A61K9/20
CPCA61K47/26A61K47/36A61K9/2086
Inventor 许林菊徐强许京京许鹏飞许宝珍王华陈新龙
Owner JIANGSU ZHONGBANG PHARMA
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