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Method for rapidly detecting caine local anesthetics added in cosmetics

A technology for local anesthetics and cosmetics, applied in the preparation of test samples, measuring devices, instruments, etc., can solve the problems of low detection accuracy and detection efficiency, improve detection accuracy and detection efficiency, and enhance surface-enhanced Raman spectroscopy The effect of intensity

Active Publication Date: 2022-03-04
江苏省食品药品监督检验研究院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problem of low detection accuracy and detection efficiency in detecting caine local anesthetics in cosmetics in the prior art, the present invention provides a method for quickly detecting caine local anesthetics added in cosmetics; by removing cosmetics before detection A large amount of protein, and then use the enhancement additive to improve the detection accuracy of the compound to be tested and reduce the influence of the protein, thus effectively solving the problem of low detection accuracy and detection efficiency of caine-like local anesthetics in cosmetics

Method used

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  • Method for rapidly detecting caine local anesthetics added in cosmetics
  • Method for rapidly detecting caine local anesthetics added in cosmetics
  • Method for rapidly detecting caine local anesthetics added in cosmetics

Examples

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Embodiment 1

[0038] In this embodiment, taking lidocaine in face cream as an example, a method for rapidly detecting the addition of caine local anesthetics in cosmetics proposed by the present invention is introduced in detail, which specifically includes the following steps:

[0039] (1) Take 4 face cream samples with a mass of 1g each (the spiked concentrations of lidocaine are 20mg / kg, 10mg / kg, 5mg / kg and 2mg / kg respectively) and 1 face cream sample without lidocaine 1g , placed in 10mL centrifuge tubes, respectively added 5mL ethyl acetate and 1mL saturated sodium chloride solution, fully oscillated and mixed, ultrasonically extracted for 3min, and centrifuged for 30s (4000r / min) to separate layers;

[0040] (2) Take the above supernatant respectively, add 1mL of nitric acid with a concentration of 0.1mol / L, fully oscillate and mix, centrifuge for 30s (4000r / min) to separate layers, and take the lower layer solution as the solution to be tested;

[0041] (3) Take 100mL of 0.01wt% chlo...

Embodiment 2

[0045] This embodiment takes chloroprocaine in face cream as an example, and introduces in detail a method for rapidly detecting caine local anesthetics added in cosmetics proposed by the present invention. The specific operation steps are basically the same as those in Example 1, the main differences are:

[0046] 1) The compound to be tested was replaced with chloroprocaine.

[0047] The final measured surface-enhanced Raman spectrum is shown in image 3 .

Embodiment 3

[0049] In this example, taking ropivacaine in face cream as an example, a method for rapidly detecting caine-like local anesthetics in cosmetics proposed by the present invention is introduced in detail. The specific operation steps are basically the same as in Example 1, and the main differences are:

[0050] 1) The compound to be tested was replaced with ropivacaine.

[0051] The final measured surface-enhanced Raman spectrum is shown in image 3 .

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Abstract

The invention discloses a method for rapidly detecting caine local anesthetics added in cosmetics, and belongs to the technical field of medicine detection. The method comprises the following steps: mixing a to-be-detected cosmetic with an organic extraction reagent and a protein precipitant to obtain a protein precipitate and a supernatant, mixing the supernatant with nano sol and an enhancing aid, and testing the surface enhanced Raman spectrum of the mixture; the nano sol comprises metal nano sol, and the reinforcing auxiliary agent comprises haloid. Whether the caine local anesthetics are added into the cosmetics or not can be rapidly detected on site, and therefore the detection precision and the detection efficiency are improved at the same time.

Description

technical field [0001] The invention belongs to the technical field of drug detection, and more specifically relates to a method for rapidly detecting caine local anesthetics added in cosmetics. Background technique [0002] Local anesthetics, referred to as "local anesthetics", are a class of drugs that can reversibly block the occurrence and transmission of sensory nerve impulses locally, and can reversibly cause pain loss in local tissues while maintaining a clear consciousness. According to the "Safety and Technical Specifications for Cosmetics" (2015 Edition), local anesthetics are prohibited from being added to cosmetics. However, these local anesthetics are illegally added to many anti-wrinkle, anti-aging and local repair cosmetics. The reason is that when these drugs are used, the skin cells will lose their activity in a short time, temporarily paralyzing and stiffening the facial skin and muscles, so the skin looks as if Much smoother. Long-term or large-scale use...

Claims

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Application Information

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IPC IPC(8): G01N21/65G01N1/34G01N1/38
CPCG01N21/658G01N1/34G01N1/38
Inventor 方方张再平曹玲夏婧竹冯有龙张苗苗宫旭
Owner 江苏省食品药品监督检验研究院
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