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Imaging optical system based on SPR angular spectrum

An imaging optics and angular spectrum technology, applied in the field of imaging optical systems based on SPR angular spectrum, can solve the problems of poor image resolution and contrast between light and dark, imperfect optical path design, etc. The effect of light and dark contrast or contrast

Inactive Publication Date: 2022-03-08
北京英柏生物科技有限公司
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Problems solved by technology

[0019] In view of this, an embodiment of the present invention provides an imaging optical system based on the SPR angular spectrum to solve the problems in the prior art when the optical path design is not perfect when the SPR angular modulation spectrum is used for SPR sensing detection. poor technical problem

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  • Imaging optical system based on SPR angular spectrum
  • Imaging optical system based on SPR angular spectrum
  • Imaging optical system based on SPR angular spectrum

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Embodiment Construction

[0043] As mentioned in the background technology, although the current SPR angular spectrum wedge beam projection technology has the advantage of being able to record the SPR angular spectrum in real time and dynamically, the image resolution and The contrast between light and dark still needs to be improved.

[0044] The first is the problem of the light source. The current SPR wedge-shaped beam angle spectrum projection method generally uses a high-power monochromatic light-emitting diode (LED) as the light source of the optical system, and the subsequent optical system performs beam expansion and collimation on the divergent beam it emits, and then The collimated beam is converged into a wedge-shaped beam through the cylindrical lens group, and then enters the cylindrical prism sensor. Although the cost of LED light source is low and easy to control, it also has inevitable defects: LED is not a point light source, and its light is emitted from a small light-emitting surface...

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Abstract

The invention discloses an imaging optical system based on an SPR angular spectrum. The imaging optical system comprises a light emitting unit, a first beam expanding collimating mirror group, a decoherence mirror group, a polarizer group, a front cylindrical convergent mirror group, an SPR sensor, a rear cylindrical collimating mirror group and a projection unit which are arranged in sequence, the light-emitting unit comprises a light source and a single-mode fiber. Light beams output by the light source generate an incident point light source through the single-mode fiber to be output. The first beam expanding and collimating mirror group is connected with an incident point light source for beam expanding and collimating; the decoherence mirror group receives the collimated light beam for decoherence; the polarizer group receives the decoherence light beam for polarization; the front cylindrical convergent mirror group receives the P polarized light and converges the P polarized light; the SPR sensor receives the convergent light beam to carry out SPR detection; and the rear cylindrical collimating lens group receives the wedge-shaped light beam, collimates the wedge-shaped light beam and then outputs the wedge-shaped light beam to the projection unit for imaging. According to the invention, the projection imaging resolution of the SPR angular spectrum and the sharpness of the image are improved. And light beam imaging with SPR angular spectrum information is realized.

Description

technical field [0001] The invention relates to the field of imaging, in particular to an imaging optical system based on SPR angular spectrum. Background technique [0002] Surface Plasmon Resonance (SPR) detection technology is a new biochemical sensing analysis technology based on the SPR principle. Due to the characteristics of high sensitivity, real-time response, dynamic monitoring, high throughput, small sample volume and no need for labeling, this technology has been widely used in life sciences, medical testing, drug screening, food testing, doping testing, drug testing and the environment. Monitoring and other fields have a wide range of application requirements. [0003] The physical model of the SPR detection sensor is shown in Fig. 1(a) and Fig. 1(b). Among them, the main body of the SPR sensor is a prism with a gold-coated reflective surface. The prism of the SPR sensor has two configurations: cylindrical prism configuration and trapezoidal prism configurati...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/01G01N21/552G02B27/09G02B27/30G02B27/48
CPCG01N21/01G01N21/554G02B27/48G02B27/09G02B27/30
Inventor 江先玉李洪增王金海
Owner 北京英柏生物科技有限公司
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