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Method capable of improving hygroscopicity of monascus extract

An extract and hygroscopic technology, which can be used in the field of improving the hygroscopicity of red yeast extract, can solve the problems of fast hygroscopicity, and achieve the effects of improving hygroscopicity, reducing the hygroscopic speed and high recovery rate.

Pending Publication Date: 2022-03-15
ALPHA FUJIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the moisture absorption rate is faster in the methods disclosed in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A method that can improve the hygroscopicity of red yeast rice extract, is characterized in that, comprises the steps:

[0033] (1) Extraction: mix red yeast rice powder and ethanol with a volume fraction of 65%, the solid-liquid ratio of red yeast rice powder and ethanol is 1g:10ml, extract at normal pressure in an extraction tank, the extraction temperature is 50 ° C, the extraction time For 2h, after the extraction is completed, the extract solution is subjected to plate and frame filtration to obtain the extract solution;

[0034] (2) primary filtration: the extract is subjected to microfiltration, and the microfiltration all adopts a 1um ceramic membrane, and microfiltration removes small molecular impurities in the liquid to obtain a primary filtrate;

[0035] (3) primary concentration: the primary filtrate is vacuum concentrated in a concentration tank until the volume is 60% of the original volume to obtain a concentrated solution;

[0036] (4) Resin adsorption...

Embodiment 2

[0042] A method that can improve the hygroscopicity of red yeast rice extract, is characterized in that, comprises the steps:

[0043] (1) Extraction: mix red yeast rice powder and ethanol with a volume fraction of 72.5%, the solid-to-liquid ratio of red yeast rice powder and ethanol is 1g:15ml, extract at normal pressure in the extraction tank, the extraction temperature is 60 ° C, the extraction time 1.25h, after the extraction is completed, the extract is filtered with a plate and frame to obtain the extract;

[0044] (2) primary filtration: the extract is subjected to microfiltration treatment, and the microfiltration all adopts a 1.5um ceramic membrane, and microfiltration removes small molecule impurities in the liquid to obtain a primary filtrate;

[0045] (3) primary concentration: the primary filtrate is vacuum concentrated in a concentration tank until the volume is one-third of the original volume to obtain a concentrated solution;

[0046] (4) Resin adsorption and...

Embodiment 3

[0052] A method that can improve the hygroscopicity of red yeast rice extract, is characterized in that, comprises the steps:

[0053] (1) Extraction: the red yeast rice powder and the ethanol that volume fraction is 80% are mixed evenly, and the solid-liquid ratio of red yeast rice powder and ethanol is 1g:20ml, extracts at normal pressure in extraction tank, and extraction temperature is 70 ℃, extraction time 0.5h, after the extraction is completed, the extract is filtered with a plate and frame to obtain the extract;

[0054](2) primary filtration: the extract is subjected to microfiltration, and the microfiltration all adopts a 2um ceramic membrane, and microfiltration removes small molecule impurities in the liquid to obtain a primary filtrate;

[0055] (3) primary concentration: the primary filtrate is vacuum concentrated in a concentration tank until the volume is 70% of the original volume to obtain a concentrated solution;

[0056] (4) Resin adsorption and elution: t...

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Abstract

The invention relates to a method capable of improving the hygroscopicity of a monascus extract, the method can obviously improve the hygroscopicity of the monascus extract, after monascus extract powder treated by the method is placed at the humidity of 50% for three days, the critical relative humidity (CRH) can be improved by about 8.51%, the moisture absorption speed of the extract is reduced, and the hygroscopicity of the monascus extract is improved; the content of molacolin K in the monascus extract treated by the method is greater than or equal to 10%, and is far higher than that of a commercially available monascus extract; the method provided by the invention has the advantages of high recovery rate, less loss, simple process and lower cost, and can be used for industrial production, and the recovery rate is greater than 80% in terms of molacrilin K.

Description

technical field [0001] The invention belongs to the field of chemical and biological technology, and in particular relates to a method for improving the hygroscopicity of red yeast rice extract. Background technique [0002] Red yeast rice has a long history in our country, and it is a traditional Chinese medicinal material for both diet and therapy in ancient times. In 1979, Akira Endo et al. isolated a potent cholesterol-lowering active substance, moraclin K, from the culture of red yeast rice. With its significant effect of lowering plasma cholesterol and low-density cholesterol, moraclin K became the most active substance in the world. Best-selling blood lipid-lowering drug. [0003] However, there are currently mature technical means to extract moraclin K from the red yeast group. However, since the main components of the red yeast culture are rice and other natural grains, the ingredients are relatively complex, so the red yeast extract is rich in sugar. Very hygrosc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K36/062A61K9/14A61K47/36
CPCA61K36/899A61K36/062A61K9/146A61K2236/19A61K2236/333A61K2236/51A61K2236/55A61K2300/00
Inventor 高益槐戴金玉李小娟钟梅坤姚璐高全
Owner ALPHA FUJIAN BIOTECH
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